Integrin beta 1
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 10: 32.9 – 33.01 Mb | Chr 8: 129.41 – 129.46 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Integrin beta-1 (ITGB1), also known as CD29, is a
Integrin beta 1 is expressed as at least four different
Structure
Integrin beta-1 can exist as different
Function
Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells.[7] Integrins link the actin cytoskeleton with the extracellular matrix and they transmit signals bidirectionally between the extracellular matrix and cytoplasmic domains.[9][10] Beta-integrins are primarily responsible for targeting integrin dimers to the appropriate subcellular locations, which in adhesive cells is mainly focal adhesions.[8][11] Integrin beta-1 mutants lose the ability to target to sites of focal adhesions.[12][13]
Three novel isoforms of integrin beta-1 have been identified, termed beta-1B, beta-1C and beta-1D. Integrin beta-1B is transcribed when the proximal 26
Integrin beta-1D appears to be developmentally regulated during myofibrilogenesis,
Clinical significance
In patients with
In patients with sensitive-motor
Interactions
CD29 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000150093 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025809 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 36485270.
- ^ "Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)".
- ^ S2CID 32774108.
- ^ PMID 8240826.
- S2CID 28558568.
- PMID 8689569.
- PMID 1373145.
- PMID 7515874.
- PMID 1376731.
- PMID 2249781.
- PMID 7523423.
- PMID 1551917.
- PMID 7545312.
- PMID 7545396.
- ^ S2CID 86638879.
- ^ PMID 8567725.
- PMID 15547664.
- PMID 18537849.
- PMID 2116421.
- PMID 7691808.
- PMID 10741407.
- PMID 8630057.
- ^ PMID 12175627.
- PMID 10906324.
- ^ PMID 11807098.
- PMID 9722563.
- PMID 10229664.
- ^ PMID 12435334.
- PMID 9442085.
- PMID 9281591.
- PMID 11741908.
- PMID 10852818.
- S2CID 9977605.
- PMID 11919189.
- PMID 12138200.
- PMID 2468126.
- S2CID 4356748.
- PMID 9360996.
- S2CID 7405925.
Further reading
- Evans JP (Jul 2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. S2CID 23712246.
- Armulik A (Jan 2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions". Frontiers in Bioscience. 7 (1–3): d219-27. PMID 11779688.
- Brakebusch C, Fässler R (Sep 2005). "beta 1 integrin function in vivo: adhesion, migration and more". Cancer and Metastasis Reviews. 24 (3): 403–11. S2CID 24210890.
External links
- CD29+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human ITGB1 genome location and ITGB1 gene details page in the UCSC Genome Browser.