Interleukin 12
Human Interleukin 12 | |
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Identifiers | |
Symbol | IL12, p70 |
PDB | 1F45 |
Chr. 3 p12-q13.2 | |||||||
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Chr. 5 q31.1-33.1 | |||||||
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Interleukin 12 (IL-12) is an
Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.Gene and structure
IL12 is a
Functions
IL-12 is involved in the differentiation of naive
IL-12 plays an important role in the activities of
IL-12 also has anti-
Signal transduction
IL-12 binds to the IL-12 receptor, which is a heterodimeric receptor formed by
An extensive review and visualization of IL-12 signaling can be found at the peer-reviewed pathway database Reactome: Interleukin-12 family
Autoimmunity
IL-12 is linked with
Results published in the Journal of Allergy and Clinical Immunology from a study where mice that were bred to be allergic to peanuts, interleukin-12 has been shown to not be present, suggesting that the molecule normally stops allergies to food from developing. Further investigation is underway, to determine whether the results found in mice are as profound in humans.[8][9]
IL-12 and IL-12 receptor β1 mutations
Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (
A child with
Support is lent to this idea by the observation that a
Defective Th1 and Th17 immune responses leading to
See also
- CNTO 1275
References
- S2CID 10617490.
- PMID 22814351.
- PMID 8097338.
- PMID 27734411
- PMID 31360139.
- PMID 8943050.
- PMID 10807786. Archived from the originalon 2013-04-15.
- PMID 17599398.
- ^ "Food allergy molecule discovered". BBC News. 1 July 2007.
- PMID 10959079.
- ISBN 978-0-19-514774-2.
- ^ PMID 9603732.
- PMID 21714643.
Further reading
- Guenova E, Volz T, Sauer K, Kaesler S, Müller MR, Wölbing F, et al. (November 2008). "IL-4-mediated fine tuning of IL-12p70 production by human DC". European Journal of Immunology. 38 (11): 3138–49. S2CID 25717745.