Interleukin-3 receptor
Chr. X p22.3 |
---|
interleukin 3 receptor, Y-Chromosomal | |
---|---|
Identifiers | |
Symbol | IL3RA |
Alt. symbols | IL3RY, IL3RAY |
Chr. Y p11.3 |
The interleukin-3 receptor (
interleukin-3, a soluble cytokine important in the immune system
.
The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.
The receptor belongs to the
heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit
.
The gene for the alpha subunit is 40
kilobases long and has 12 exons
.
Cell types and function
The receptor, found on
cDCs
among peripheral blood mononuclear cells.
CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells.[1]
Possible drug target
Tagraxofusp, human IL-3 fused to diphtheria toxin, is an approved treatment for BPDCN. An experimental
antibody-drug conjugate SGN-CD123A targets CD123 as a possible treatment for AML.[1]
References
External links
- Interleukin-3+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)