Interleukin-5 receptor
Chr. 3 p26-p24 | |||||||
|---|---|---|---|---|---|---|---|
| |||||||
Chr. 22 q12.2-13.1 | |||||||
|---|---|---|---|---|---|---|---|
| |||||||
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB.[1][2]
The IL-5 receptor (IL-5R) belongs to the
polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the signal transduction
domains.
α-subunit
The IL-5Rα chain is exclusively expressed by eosinophils, some
β-subunit
The β-subunit of the IL-5 receptor is responsible for signal transduction and contains several intracellular signaling domains. Unlike the α-chain, the β-chain does not bind IL-5, is not specific to this cytokine, and is expressed on practically all
JAK2,[8] as well as LYN,[9] another tyrosine kinase, which are both essential for IL-5 signal transduction.[10]
Drug target
Three monoclonal antibodies are available to target IL-5R. Benralizumab binds to IL-5Ra, while mepolizumab and reslizumab bind to IL-5, preventing it from binding to IL-5Ra.
References
External links
- Receptors,+Interleukin-5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)