Interleukin 16
IL16 | |||
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Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 15: 81.16 – 81.31 Mb | Chr 7: 83.29 – 83.39 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Interleukin 16 is a pro-inflammatory pleiotropic cytokine. Its precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene.[5][6] This gene was discovered in 1982 at Boston University by Dr. David Center and Dr. William Cruikshank.[7]
Function
The cytokine encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of
dendritic cells.[8]
The structure of IL-16 was determined following its
cloning in 1994.[9] This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor
for mature IL-16.
Interactions
Interleukin 16 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000172349 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001741 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9144227.
- ^ a b "Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)".
- ^ S2CID 33890529.
- PMID 10857846.
- PMID 7910967.
- ^ PMID 10479680.
- ^ PMID 12923170.
Further reading
- Wilson KC, Center DM, Cruikshank WW (June 2004). "The effect of interleukin-16 and its precursor on T lymphocyte activation and growth". Growth Factors. 22 (2): 97–104. S2CID 16860935.
- Copeland KF (December 2005). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry. 5 (12): 1093–1101. PMID 16375755.
- Rand TH, Cruikshank WW, Center DM, Weller PF (June 1991). "CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration". The Journal of Experimental Medicine. 173 (6): 1521–1528. PMID 1851800.
- Ryan TC, Cruikshank WW, Kornfeld H, Collins TL, Center DM (July 1995). "The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration". The Journal of Biological Chemistry. 270 (29): 17081–17086. PMID 7615501.
- Cruikshank WW, Center DM, Nisar N, Wu M, Natke B, Theodore AC, Kornfeld H (May 1994). "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression". Proceedings of the National Academy of Sciences of the United States of America. 91 (11): 5109–5113. PMID 7910967.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. PMID 8125298.
- Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM (February 1996). "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C". Cellular Immunology. 168 (1): 100–106. PMID 8599832.
- Bannert N, Baier M, Werner A, Kurth R (May 1996). "Interleukin-16 or not?". Nature. 381 (6577): 30. S2CID 4347508.
- Maciaszek JW, Parada NA, Cruikshank WW, Center DM, Kornfeld H, Viglianti GA (January 1997). "IL-16 represses HIV-1 promoter activity". Journal of Immunology. 158 (1): 5–8. S2CID 28041095.
- Laberge S, Ernst P, Ghaffar O, Cruikshank WW, Kornfeld H, Center DM, Hamid Q (August 1997). "Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma". American Journal of Respiratory Cell and Molecular Biology. 17 (2): 193–202. PMID 9271307.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. PMID 9373149.
- Zhang Y, Center DM, Wu DM, Cruikshank WW, Yuan J, Andrews DW, Kornfeld H (January 1998). "Processing and activation of pro-interleukin-16 by caspase-3". The Journal of Biological Chemistry. 273 (2): 1144–1149. PMID 9422780.
- Mühlhahn P, Zweckstetter M, Georgescu J, Ciosto C, Renner C, Lanzendörfer M, et al. (August 1998). "Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site". Nature Structural Biology. 5 (8): 682–686. S2CID 39286954.
- Chupp GL, Wright EA, Wu D, Vallen-Mashikian M, Cruikshank WW, Center DM, et al. (September 1998). "Tissue and T cell distribution of precursor and mature IL-16". Journal of Immunology. 161 (6): 3114–3119. S2CID 11896037.
- Bannert N, Avots A, Baier M, Serfling E, Kurth R (February 1999). "GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1541–1546. PMID 9990060.
- Kim HS (1999). "Assignment of human interleukin 16 (IL16) to chromosome 15q26.3 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 84 (1–2): 93. S2CID 83880527.
- Liu Y, Cruikshank WW, O'Loughlin T, O'Reilly P, Center DM, Kornfeld H (August 1999). "Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation". The Journal of Biological Chemistry. 274 (33): 23387–23395. PMID 10438516.
- Kaser A, Dunzendorfer S, Offner FA, Ryan T, Schwabegger A, Cruikshank WW, et al. (September 1999). "A role for IL-16 in the cross-talk between dendritic cells and T cells". Journal of Immunology. 163 (6): 3232–3238. S2CID 36053665.
- Kurschner C, Yuzaki M (September 1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". The Journal of Neuroscience. 19 (18): 7770–7780. PMID 10479680.
External links
- Overview of all the structural information available in the PDB for UniProt: Q14005 (Interleukin-16) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.