Interleukin 16

Source: Wikipedia, the free encyclopedia.
IL16
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_010551
NM_001360087
NM_001360088
NM_001360089

RefSeq (protein)

NP_034681
NP_001347016
NP_001347017
NP_001347018

Location (UCSC)Chr 15: 81.16 – 81.31 MbChr 7: 83.29 – 83.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 16 is a pro-inflammatory pleiotropic cytokine. Its precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene.[5][6] This gene was discovered in 1982 at Boston University by Dr. David Center and Dr. William Cruikshank.[7]

Function

The cytokine encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of

dendritic cells.[8]

The structure of IL-16 was determined following its

cloning in 1994.[9] This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an enzyme called caspase-3 to become active. CD4 is the cell signaling receptor
for mature IL-16.

Interactions

Interleukin 16 has been shown to

interact
with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172349 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001741 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 9144227
    .
  6. ^ a b "Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)".
  7. ^
    S2CID 33890529
    .
  8. .
  9. .
  10. ^ .
  11. ^ .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.