Interleukin-1 receptor antagonist protein

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Interleukin 1 receptor antagonist
)
IL1RN
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl

ENSG00000136689

ENSMUSG00000026981

UniProt

P18510

P25085

RefSeq (mRNA)

NM_001039701
NM_001159562
NM_031167

RefSeq (protein)

NP_001034790
NP_001153034
NP_112444

Location (UCSC)Chr 2: 113.1 – 113.13 MbChr 2: 24.23 – 24.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The interleukin-1 receptor antagonist protein (IL-1RN) is a protein that in humans is encoded by the IL1RN gene.[5][6]

IL-1RN was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories.

interleukin 1
family (IL-1), preventing IL-1's from sending a signal to that cell.

Function

IL-1RA is a member of the interleukin 1

IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[9]

Clinical significance

A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures

gastric cancer.[11]

Mutations in the IL1RN gene results in a rare disease called deficiency of the interleukin-1–receptor antagonist (DIRA).[12] Variants of the IL1RN gene is also associated with risk of schizophrenia.[13][14] Elevated levels of IL1RN has been found in serum of schizophrenia patients.[15]

A recombinant, slightly modified version of interleukin 1 receptor antagonist called

autoimmune disease in which IL-1 plays a key role.[16] Anakinra differs from native human IL-1Ra in that it has the addition of a single methionine residue at its amino terminus [17]

Use in horses

Interleukin 1 receptor antagonist is used in horses for the treatment of equine lameness secondary to joint and soft-tissue injury.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136689 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026981 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 1386337
    .
  6. PMID 8432529
    .
  7. S2CID 10404996
    .
  8. S2CID 23087836
    .
  9. ^ "Entrez Gene: IL1RN interleukin 1 receptor antagonist".
  10. S2CID 23035139
    .
  11. S2CID 1288472
    .
  12. PMID 19494218
    .
  13. S2CID 43435475
    .
  14. PMID 14563376
    .
  15. PMID 19839997
    .
  16. PMID 19160248
    .
  17. ^ "Kineret (anakinra) injection, for subcutaneous use" (PDF). Swedish Orphan Biovitrum.

Further reading

External links
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