Interleukin 9
IL9 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process | |||
Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 5: 135.89 – 135.9 Mb | Chr 13: 56.63 – 56.63 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Interleukin 9, also known as IL-9, is a
CD4+ T cells that produce IL-9.[6]
Functions
Il-9 is a
hematopoietic cells.[7] This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins namely STAT1, STAT3 and STAT5 and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.[5]
Interleukin-9 has also shown to inhibit melanoma growth in mice. [8]
Additionally, it gives rise to the multiplication of
Hodgkin's lymphoma in humans but IL-9 also has antitumor properties in solid tumors, for example melanoma.[6]
Discovery
IL-9 was first described in the late 1980s as a member of a growing number of
lymphoid cells.[9]
The identification and
cDNA was isolated again by cross-hybridization with the mouse IL-9 probe.[10]
Gene location
The human IL-9 gene is located on the long arm of human
chromosome 5 at band 5q31-32, a region which is not found in a number of patients with acquired chromosome 5q deletion syndrome.[11]
Protein structure
Human IL-9
polypeptide and 4 N-linked glycosylation sites.[10] Until recently, IL-9 was thought to be evolutionary related to IL-7.[12] However, we know now that IL-9 is closer to IL-2 and IL-15 than to IL-7,[13]
at both the tertiary and amino acid sequence levels.
Production
TGF-β is an essential factor for IL-9 induction.[15] For the first time (Lars Blom, Britta C. Poulsen, Bettina M. Jensen, Anker Hansen and Lars K. Poulsen published a journal online in 2011 Jul 6),indicating that TGF-β may be important for production of IL-9 but it is not only the definite requirement for IL-9 induction, since cultures with IL-33 without TGF-β have noticeably increased secretion of IL-9, suggesting an important role of IL-33, even though that the effect was not found significant on the gene level.[16]
IL-9 expression
The analysis of IL-9 expression in different types of
B and T-cell lymphomas
, but it may have a part in HD and LCAL autocrine growth.
The further investigation could be done to conclude another probability, that, the
symptoms related to eosinophilia which was recently reported for Interleukin 5 positive cases of HD.[17]
IL-9 was found to be the first physiological stimulus triggering BCL3 expression in T cells and mast cells by the analysis done in mouse.[18]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145839 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021538 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: IL9 interleukin 9".
- ^ PMID 28477184.
- PMID 21371941.
- PMID 22772464.
- Lay summary in: "Scientists find molecule in immune system that could help treat dangerous skin cancer". MedicalXpress. July 8, 2012.
- PMID 21368237.
- ^ PMID 8821582.
- PMID 1901233.
- S2CID 42479456.
- S2CID 73449371.
- PMID 18250453.
- PMID 20498357.
- PMID 21765905.
- PMID 1908723.
- PMID 10361130.
Further reading
- Renauld JC, Houssiau F, Louahed J, Vink A, Van Snick J, Uyttenhove C (1993). "Interleukin-9". Advances in Immunology Volume 54. Vol. 54. pp. 79–97. PMID 8379467.
- Knoops L, Renauld JC (December 2004). "IL-9 and its receptor: from signal transduction to tumorigenesis". Growth Factors. 22 (4): 207–15. S2CID 40523692.
- Modi WS, Pollock DD, Mock BA, Banner C, Renauld JC, Van Snick J (1991). "Regional localization of the human glutaminase (GLS) and interleukin-9 (IL9) genes by in situ hybridization". Cytogenetics and Cell Genetics. 57 (2–3): 114–6. PMID 1680606.
- Kelleher K, Bean K, Clark SC, Leung WY, Yang-Feng TL, Chen JW, Lin PF, Luo W, Yang YC (April 1991). "Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells". Blood. 77 (7): 1436–41. PMID 1901233.
- Holbrook ST, Ohls RK, Schibler KR, Yang YC, Christensen RD (May 1991). "Effect of interleukin-9 on clonogenic maturation and cell-cycle status of fetal and adult hematopoietic progenitors". Blood. 77 (10): 2129–34. PMID 1903074.
- Merz H, Houssiau FA, Orscheschek K, Renauld JC, Fliedner A, Herin M, Noel H, Kadin M, Mueller-Hermelink HK, Van Snick J (September 1991). "Interleukin-9 expression in human malignant lymphomas: unique association with Hodgkin's disease and large cell anaplastic lymphoma". Blood. 78 (5): 1311–7. PMID 1908723.
- Renauld JC, Goethals A, Houssiau F, Merz H, Van Roost E, Van Snick J (June 1990). "Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene". Journal of Immunology. 144 (11): 4235–41. S2CID 30151082.
- Renauld JC, Goethals A, Houssiau F, Van Roost E, Van Snick J (January 1990). "Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40". Cytokine. 2 (1): 9–12. PMID 2129501.
- Yang YC, Ricciardi S, Ciarletta A, Calvetti J, Kelleher K, Clark SC (November 1989). "Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40". Blood. 74 (6): 1880–4. PMID 2508790.
- Yin T, Keller SR, Quelle FW, Witthuhn BA, Tsang ML, Lienhard GE, Ihle JN, Yang YC (September 1995). "Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases". The Journal of Biological Chemistry. 270 (35): 20497–502. PMID 7544789.
- Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC (October 1995). "Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy". The New England Journal of Medicine. 333 (14): 894–900. PMID 7666875.
- Le Beau MM, Espinosa R, Neuman WL, Stock W, Roulston D, Larson RA, Keinanen M, Westbrook CA (June 1993). "Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases". Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5484–8. PMID 8516290.
- Demoulin JB, Uyttenhove C, Van Roost E, DeLestré B, Donckers D, Van Snick J, Renauld JC (September 1996). "A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9". Molecular and Cellular Biology. 16 (9): 4710–6. PMID 8756628.
- Nicolaides NC, Holroyd KJ, Ewart SL, Eleff SM, Kiser MB, Dragwa CR, Sullivan CD, Grasso L, Zhang LY, Messler CJ, Zhou T, Kleeberger SR, Buetow KH, Levitt RC (November 1997). "Interleukin 9: a candidate gene for asthma". Proceedings of the National Academy of Sciences of the United States of America. 94 (24): 13175–80. PMID 9371819.
- Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC (September 1999). "Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9". The Journal of Biological Chemistry. 274 (36): 25855–61. PMID 10464327.
- Lejeune D, Demoulin JB, Renauld JC (January 2001). "Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling". The Biochemical Journal. 353 (Pt 1): 109–116. PMID 11115404.
- Little FF, Cruikshank WW, Center DM (September 2001). "Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells". American Journal of Respiratory Cell and Molecular Biology. 25 (3): 347–52. PMID 11588013.
- Toda M, Tulic MK, Levitt RC, Hamid Q (February 2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". The Journal of Allergy and Clinical Immunology. 109 (2): 246–50. PMID 11842292.
- Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y (April 2002). "IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta". Journal of Immunology. 168 (8): 4103–11. PMID 11937570.