Intimal hyperplasia
Intimal hyperplasia is the thickening of the
bypass graft failure, particularly in vein and synthetic vascular grafts.[2]
Cause
Intimal hyperplasia is due to a dysfunction of
vascular smooth muscle cells (VSMCs). As a result, VSMCs proliferate and change their phenotype. [1]
Possible treatment
A possible treatment to avoid this could be hydrogen sulfide. Hydrogen sulfide (H2S) works as a vasculoprotective gasotransmitter in the human body but is also tested to reduced intimal hyperplasia. There are different kinds of H2S donors: NaHS (the reference in scientific literature despite the fact it is too toxic to use it in human patients) and STS (already used in patient to treat cyanide poisoning).
See also
- Hyperplasia
- Medical grafting
References
- ISBN 978-0-7216-9691-1. Retrieved 20 October 2021.
- S2CID 24921182.
Déglise S, Bechelli C, Allagnat F. Vascular smooth muscle cells in intimal hyperplasia, an update. Front Physiol. 2023 Jan 4;13:1081881. doi: 10.3389/fphys.2022.1081881. PMID 36685215; PMCID: PMC9845604.[2]
External links