Ionotropic glutamate receptor
Lig_chan | |||||||||
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TCDB 1.A.10 | | ||||||||
OPM superfamily | 8 | ||||||||
OPM protein | 3kg2 | ||||||||
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Ionotropic glutamate receptors (iGluRs) are
AMPA receptors are the main charge carriers during basal transmission, permitting influx of
iGluRs are tetramers (they are formed of four subunits). All subunits have a shared architecture with four domain layers: two extracellular clamshell domains called the N-terminal domain (NTD) and ligand-binding domain (LBD; which binds glutamate), the transmembrane domain (TMD) that forms the ion channel, and an intracellular C-terminal domain (CTD).[5]
Human proteins/genes encoding iGluR subunits
AMPA receptors: GluA1/GRIA1; GluA2/GRIA2; GluA3/GRIA3; GluA4/GRIA4;
delta receptors: GluD1/GRID1; GluD2/GRID2;
kainate receptors: GluK1/GRIK1; GluK2/GRIK2; GluK3/GRIK3; GluK4/GRIK4; GluK5/GRIK5;
NMDA receptors: GluN1/GRIN1; GluN2A/GRIN2A; GluN2B/GRIN2B; GluN2C/GRIN2C; GluN2D/GRIN2D; GluN3A/GRIN3A; GluN3B/GRIN3B;