Isabella Eckerle

Source: Wikipedia, the free encyclopedia.

Isabella Eckerle
Born
Alma materHeidelberg University
Known forVirology
Scientific career
InstitutionsUniversity Hospital Heidelberg
University of Bonn
Academic advisorsChristian Drosten

Isabella Eckerle is a German virologist who is the co-Head of the Centre for Emerging Viral Diseases at the

coronavirus disease
.

Early life and education

Eckerle was born in Speyer, Rhineland-Palatinate.[1] As a child she wanted to be a veterinarian or a field biologist, but ended up studying medicine at Heidelberg University.[1] During her final year of medical school she visited Africa, which inspired her to work in infectious diseases.[1] She decided to specialize in tropical pathogens, and spent her early medical career working in the Department of Tropical Medicine at the University Hospital Heidelberg. As a junior doctor Eckerle investigated the pathogenesis of travellers returning to Germany from abroad. She focussed on viruses of zoonotic origin.[1]

Research and career

Eckerle moved to the

renal epithelial cell lines of various reservoir hosts, including bats, rodents and insectivores.[3] Until the works of Eckerle, the isolation of bat-borne viruses in cell culture had been challenging. Eckerle created an experimental approach to instantly freeze the organs of specimens, so-called cryo-conservation, allowing her access to cells from a variety of rare species. She visited Ghana and Gabon as part of field work missions to study and collect bat species.[1]

In 2018 Eckerle was made a Professor at the

At the Geneva University Hospitals, she is co-head of the Center for Emerging Viral Diseases.[6]

In the early days of the

coronavirus disease.[8] In late April 2020, a serological antibody test in Geneva revealed that only 5.5% of the population had been exposed to the disease, which Eckerle described as "smaller than hoped for,".[9] Eckerle investigated the different responses of adults and children to coronavirus disease.[10][11] In particular, Eckerle studied the presence of SARS-CoV-2 in the upper respiratory tracts of neonates, children and teenagers. In early May, Eckerle reported that children who fell ill with coronavirus disease were just as infectious as adults.[12][13] She investigated the viral loads of children and adults, and showed that whilst children can have a more mild form of the disease, there was little difference between the number of SARS-CoV-2 particles carried by adults and children.[14] She was awarded funding from the Swiss National Science Foundation to investigate the reaction of the pulmonary epithelium to SARS-CoV-2 infection, in an effort to create diagnostic guidelines that help healthcare workers evaluate whether someone will contract a mild or severe form of disease.[15]

Selected publications

References

  1. ^ a b c d e "Cellosaurus - invitromaticists spotlight". web.expasy.org. Retrieved 19 May 2020.
  2. ^ Semmler, Ilia. "Drosten Lab". Institute of Virology. Retrieved 19 May 2020.
  3. PMID 24454736
    .
  4. ^ a b "[993] Emerging viruses". www.unige.ch. 5 June 2018. Retrieved 19 May 2020.
  5. ^ "MERS: Getting a Handle on a Serious Zoonotic Coronavirus Infection". GEN - Genetic Engineering and Biotechnology News. 15 June 2014. Retrieved 19 May 2020.
  6. ^ "Organisation du laboratoire de virologie à Genève aux HUG | HUG - Hôpitaux Universitaires de Genève". www.hug.ch (in French). 6 October 2020. Retrieved 21 October 2020.
  7. ^ "Swiss seek access to EU early-warning system as coronavirus spreads". Reuters. 28 January 2020. Retrieved 19 May 2020.
  8. PMID 32075791
    .
  9. ^ "Geneva Covid-19 study: undetected cases, but too few for herd immunity". swissinfo.ch. Retrieved 19 May 2020.
  10. ^ "The Lurking Mystery of the Pandemic: Why Is It Gentler on Children?". OZY. 10 May 2020. Retrieved 19 May 2020.
  11. ^ "Enfants et contagion: une nouvelle étude questionne les certitudes de l'OFSP". rts.ch (in French). 1 May 2020. Retrieved 19 May 2020.
  12. ^ Vogel, Gretchen; Couzin-Frankel, Jennifer (4 May 2020). "Should schools reopen? Kids' role in pandemic still a mystery". Science | AAAS. Retrieved 19 May 2020.
  13. ^ Arens, Marianne. "Germany reopens schools, endangering thousands of lives". www.wsws.org. Retrieved 19 May 2020.
  14. ^ Staton, Bethan (8 May 2020). "Effects of coronavirus in children adds to list of Covid-19 unknowns". Financial Times. Retrieved 19 May 2020.
  15. ^ "Le FNS encourage 36 nouveaux projets de recherche sur les coronavirus - SNF". www.snf.ch. Retrieved 19 May 2020.