Isocarboxazid

Source: Wikipedia, the free encyclopedia.
Isocarboxazid
Clinical data
Trade namesMarplan
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa605036
Pregnancy
category
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • BR: Class C1 (Other controlled substances)[2]
  • US: WARNING[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityLow, peak at 1-2 h[3]
MetabolismLiver (Carboxylesterase[5])
MetabolitesHippuric acid[4]
Elimination half-life1.5-4h[3]
ExcretionUrine
Identifiers
  • N′-benzyl-5-methylisoxazole-3-carbohydrazide
JSmol)
  • O=C(NNCc1ccccc1)c2noc(c2)C
  • InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16) checkY
  • Key:XKFPYPQQHFEXRZ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Isocarboxazid (Marplan, Marplon, Enerzer) is a non-selective,

irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class used as an antidepressant.[6] Along with phenelzine and tranylcypromine, it is one of only three classical MAOIs still available for clinical use in the treatment of psychiatric disorders in the United States,[7][8] though it is not as commonly employed in comparison to the others.[7][8]

Isocarboxazid is primarily used to treat mood and anxiety disorders. It has also been investigated in the treatment of schizophrenia,[9] Parkinson's disease and other dementia-related disorders.[10]

Isocarboxazid, as well as other MAOIs, increase the levels of the

epinephrine, melatonin, phenethylamine in the brain.[11]

Classical MAOIs, including isocarboxazid, are used only rarely due to prominent

aged cheeses, MAOIs can produce dangerous elevations of monoamine neurotransmitters resulting in potentially life-threatening syndromes such as hypertensive crisis and serotonin syndrome
.

See also

References

  1. FDA
    . Retrieved 22 Oct 2023.
  2. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  3. ^
    ISBN 9780702031373
    .
  4. ^ "Reaction: Isocarboxazid to 1 product". go.drugbank.com. Retrieved 27 October 2021.
  5. PMID 6178187
    .
  6. PMID 2870717
    .
  7. ^
    ISBN 978-1-134-86002-9
    .
  8. ^
    ISBN 978-1-4511-5307-1
    .
  9. PMID 13814129
    .
  10. PMID 22110357
    .
  11. S2CID 71158339
    .
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