Isradipine

Source: Wikipedia, the free encyclopedia.
Isradipine
Clinical data
Trade namesDynaCirc
AHFS/Drugs.comMonograph
MedlinePlusa693048
Pregnancy
category
  • C
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability15-24%
Protein binding95%
Metabolism100% Hepatic
Elimination half-life8 hours
Excretion70% Renal, 30% Fecal
Identifiers
  • 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
JSmol)
  • O=C(OC)\C3=C(\N\C(=C(\C(=O)OC(C)C)C3c1cccc2nonc12)C)C
  • InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 checkY
  • Key:HMJIYCCIJYRONP-UHFFFAOYSA-N checkY
  (verify)

Isradipine (tradenames DynaCirc, Prescal) is a

heart attack
.

It was patented in 1978 and approved for medical use in 1989.[1]

Medical uses

Isradipine is given as either a 2.5 mg or 5 mg capsule.[2]

Side effects

Common side effects include: [3]

  • Dizziness
  • Warmth, redness, or tingly feeling under your skin
  • Headache
  • Weakness, tired feeling
  • Nausea, vomiting, diarrhea, upset stomach
  • Skin rash or itching

Serious side effects include: [3]

  • Lightheadedness or fainting
  • Shortness of breath, especially from minimal physical activity
  • Swelling in the hands and feet
  • Rapid and/or heavy heartbeat
  • Chest pain

Drug interactions

It is advised that those using Isradipine not take Anzemet (Dolasetron), as both agents can cause a dose-dependent PR interval and QRS complex prolongation.[4]

Calcium Channel Blockers. This will increase plasma levels of Isradipine and could cause an unintentional overdose of the medication. Caution is advised when administering both agents together.[5]

anti-hypertensive effects and should be avoided in patients taking Isradipine due to the possibility of synergism between both medications.[6]

The

Rifampin lowered plasma concentrations of Isradipine to below detectable limits.[2]

Cimetidine increased Isradipine mean peak plasma levels. A downward dose adjustment may be necessary with this particular instance of polypharmacy.[2]

Severe

Calcium Channel Blocker, has not been used in conjunction with Fentanyl anesthesia in any studies, caution is advised.[2]

Overdose

Symptoms of an Isradipine overdose include:[2]

Stereochemistry

Isradipine contains a stereocenter and consists of two enantiomers, more precisely atropisomers. This is a racemate, i.e. a 1: 1 mixture of ( R ) - and the ( S ) - Form:[7]

Enantiomers of Isradipine

CAS-Nummer: 84260-63-9
CAS-Nummer: 84260-64-0

References

  1. ISBN 9783527607495
    .
  2. ^ a b c d e "Isradipine: Brands, Medical Use, Clinical Data".
  3. ^ a b "Isradipine Side Effects".
  4. ^ "Isradipine and Anzemet Drug Interactions".
  5. ^ "Isradipine and Onmel Drug Interactions".
  6. ^ "Isradipine and Zanaflex Drug Interactions".
  7. ISBN 978-3-946057-10-9
    , S. 193.

Further reading

External links