JWH-164

JWH-164
Legal status
Legal status	US: Schedule I;
Identifiers
	IUPAC name 7-Methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone;
JSmol)	Interactive image;
	SMILES CCCCCn(c4)c1ccccc1c4C(=O)c2cccc(cc3)c2cc3OC;
	InChI InChI=1S/C25H25NO2/c1-3-4-7-15-26-17-23(20-10-5-6-12-24(20)26)25(27)21-11-8-9-18-13-14-19(28-2)16-22(18)21/h5-6,8-14,16-17H,3-4,7,15H2,1-2H3; Key:IJNSZBAEVYRFCH-UHFFFAOYSA-N;
	(verify)

JWH-164 is a synthetic

naphthyl ring, rather than the 4-position as in JWH-081. Its potency is intermediate between that of JWH-081 and its ring unsubstituted derivative JWH-018, demonstrating that substitution of the naphthyl 7-position can also result in increased cannabinoid receptor binding affinity.^[1]^[2]

In the United States, all CB₁ all receptor agonists of the 3-(1-naphthoyl)indole class, including JWH-164, are

Schedule I Controlled Substances.^[3]

References

PMID 15582455
.

PMID 15974991
.

^ 21 U.S.C. § 812: Schedules of controlled substances

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[1] PMID 15582455
.

[2] PMID 15974991
.

[3] 21 U.S.C. § 812: Schedules of controlled substances

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