JWH-193

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JWH-193
Legal status
Legal status
Identifiers
  • (1-(2-Morpholin-4-ylethyl)indol-3-yl)-4-methylnaphthalen-1-ylmethanone
JSmol)
  • c3cccc1c3c(ccc1C)C(=O)c5c2ccccc2n(c5)CCN4CCOCC4
  • InChI=1S/C26H26N2O2/c1-19-10-11-23(21-7-3-2-6-20(19)21)26(29)24-18-28(25-9-5-4-8-22(24)25)13-12-27-14-16-30-17-15-27/h2-11,18H,12-17H2,1H3
  • Key:ICKWPPYMDARCKJ-UHFFFAOYSA-N
  (verify)

JWH-193 is a drug from the

naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 receptor of 6 nM, binding around seven times more tightly than the parent compound JWH-200,[1]
though with closer to twice the potency of JWH-200 in activity tests.

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-193 are

Related compounds

A structural isomer of JWH-193 with the methyl group on the indole ring instead of the naphthoyl ring, was also found to be of similarly increased potency over JWH-200.[3][4]

6-Methyl-JWH-200

See also

References

  1. PMID 15974991
    .
  2. ^ 21 U.S.C. § 812: Schedules of controlled substances
  3. PMID 7636873
    .
  4. .