James Watson

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James Watson
Chicago, Illinois
, U.S.
Alma mater
  • BS
    )
  • PhD
    )
Known for
Spouse
Elizabeth Lewis
​
(m. 1968)​
Children2
Awards
Scientific career
FieldsGenetics
Institutions
ThesisThe Biological Properties of X-Ray Inactivated Bacteriophage (1951)
Doctoral advisorSalvador Luria
Doctoral students
Other notable students
Signature

James Dewey Watson (born April 6, 1928) is an American

zoologist. In 1953, he co-authored with Francis Crick the academic paper proposing the double helix structure of the DNA molecule. Watson, Crick and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids
and its significance for information transfer in living material".

Watson earned degrees at the University of Chicago (BS, 1947) and Indiana University (PhD, 1950). Following a post-doctoral year at the University of Copenhagen with Herman Kalckar and Ole Maaløe, Watson worked at the University of Cambridge's Cavendish Laboratory in England, where he first met his future collaborator Francis Crick. From 1956 to 1976, Watson was on the faculty of the Harvard University Biology Department, promoting research in molecular biology.

From 1968, Watson served as director of

intelligence and race
. In 2019, following the broadcast of a documentary in which Watson reiterated these views on race and genetics, CSHL revoked his honorary titles and severed all ties with him.

Watson has written many science books, including the textbook Molecular Biology of the Gene (1965) and his bestselling book The Double Helix (1968). Between 1988 and 1992, Watson was associated with the National Institutes of Health, helping to establish the Human Genome Project, which completed the task of mapping the human genome in 2003.

Early life and education

Watson was born in

Catholic, he later described himself as "an escapee from the Catholic religion".[13] Watson said, "The luckiest thing that ever happened to me was that my father didn't believe in God."[14]

Watson grew up on the South Side of Chicago and attended public schools, including Horace Mann Elementary School and South Shore High School.[11][15] He was fascinated with bird watching, a hobby shared with his father,[16] so he considered majoring in ornithology.[17] Watson appeared on Quiz Kids, a popular radio show that challenged bright youngsters to answer questions.[18] Thanks to the liberal policy of university president Robert Hutchins, he enrolled at the University of Chicago, where he was awarded a tuition scholarship, at the age of 15.[11][17][19] Among his professors was Louis Leon Thurstone from whom Watson learned about factor analysis, which he would later reference on his controversial views on race.[20]

After reading Erwin Schrödinger's book, What Is Life? in 1946, Watson changed his professional ambitions from the study of ornithology to genetics.[21] Watson earned his BS degree in zoology from the University of Chicago in 1947.[17] In his autobiography, Avoid Boring People, Watson described the University of Chicago as an "idyllic academic institution where he was instilled with the capacity for critical thought and an ethical compulsion not to suffer fools who impeded his search for truth", in contrast to his description of later experiences. In 1947 Watson left the University of Chicago to become a graduate student at Indiana University, attracted by the presence at Bloomington of the 1946 Nobel Prize winner Hermann Joseph Muller, who in crucial papers published in 1922, 1929, and in the 1930s had laid out all the basic properties of the heredity molecule that Schrödinger presented in his 1944 book.[22] He received his PhD degree from Indiana University in 1950; Salvador Luria was his doctoral advisor.[17][23]

Career and research

Luria, Delbrück, and the Phage Group

Originally, Watson was drawn into molecular biology by the work of

Phage Group", an important movement of geneticists from experimental systems such as Drosophila towards microbial genetics. Early in 1948, Watson began his PhD research in Luria's laboratory at Indiana University.[23] That spring, he met Delbrück first in Luria's apartment and again that summer during Watson's first trip to the Cold Spring Harbor Laboratory (CSHL).[24][25]

The Phage Group was the intellectual medium where Watson became a working scientist. Importantly, the members of the Phage Group sensed that they were on the path to discovering the physical nature of the gene. In 1949, Watson took a course with Felix Haurowitz that included the conventional view of that time: that genes were proteins and able to replicate themselves.[26] The other major molecular component of chromosomes, DNA, was widely considered to be a "stupid tetranucleotide", serving only a structural role to support the proteins.[27] Even at this early time, Watson, under the influence of the Phage Group, was aware of the Avery–MacLeod–McCarty experiment, which suggested that DNA was the genetic molecule. Watson's research project involved using X-rays to inactivate bacterial viruses.[28]

Watson then went to

Copenhagen University in September 1950 for a year of postdoctoral research, first heading to the laboratory of biochemist Herman Kalckar.[11] Kalckar was interested in the enzymatic synthesis of nucleic acids, and he wanted to use phages as an experimental system. Watson wanted to explore the structure of DNA, and his interests did not coincide with Kalckar's.[29] After working part of the year with Kalckar, Watson spent the remainder of his time in Copenhagen conducting experiments with microbial physiologist Ole Maaløe, then a member of the Phage Group.[30]

The experiments, which Watson had learned of during the previous summer's Cold Spring Harbor phage conference, included the use of radioactive phosphate as a tracer to determine which molecular components of phage particles actually infect the target bacteria during viral infection.[29] The intention was to determine whether protein or DNA was the genetic material, but upon consultation with Max Delbrück,[29] they determined that their results were inconclusive and could not specifically identify the newly labeled molecules as DNA.[31] Watson never developed a constructive interaction with Kalckar, but he did accompany Kalckar to a meeting in Italy, where Watson saw Maurice Wilkins talk about X-ray diffraction data for DNA.[11] Watson was now certain that DNA had a definite molecular structure that could be elucidated.[32]

In 1951, the chemist

Stazione Zoologica 'Anton Dohrn' in Naples.[35]

Identifying the double helix

Science Museum, London

In mid-March 1953, Watson and Crick deduced the

Ritchie Calder in the London newspaper News Chronicle
, entitled "Why You Are You. Nearer Secret of Life".

Laboratory of Molecular Biology. According to the late Beryl Oughton, later Rimmer, they all travelled together in two cars once Dorothy Hodgkin announced to them that they were off to Cambridge to see the model of the structure of DNA.[40]

Watson's name on New York City's Nobel Monument; it lists American laureates only, not Crick and Wilkins who shared the 1962 Physics Nobel.

The Cambridge University student newspaper Varsity ran its own short article on the discovery on Saturday, May 30, 1953. Watson subsequently presented a paper on the double-helical structure of DNA at the 18th Cold Spring Harbor Symposium on Viruses in early June 1953, six weeks after the publication of the Watson and Crick paper in Nature. Many at the meeting had not yet heard of the discovery. The 1953 Cold Spring Harbor Symposium was the first opportunity for many to see the model of the DNA double helix. Watson, Crick, and Wilkins were awarded the Nobel Prize in Physiology or Medicine in 1962 for their research on the structure of nucleic acids.[11][41][42] Rosalind Franklin had died in 1958 and was therefore ineligible for nomination.[36] The publication of the double helix structure of DNA has been described as a turning point in science; understanding of life was fundamentally changed and the modern era of biology began.[43]

Interactions with Rosalind Franklin and Raymond Gosling

Watson and Crick's use of DNA X-ray diffraction data collected by Rosalind Franklin and her student Raymond Gosling has attracted scrutiny. It has been argued that Watson and his colleagues did not properly acknowledge colleague Rosalind Franklin for her contributions to the discovery of the double helix structure.[37][44] Robert P. Crease notes that "Such stingy behaviour may not be unknown, or even uncommon, among scientists".[45] Franklin's high-quality X-ray diffraction patterns of DNA were unpublished results, which Watson and Crick used without her knowledge or consent in their construction of the double helix model of DNA.[44][36][46] Franklin's results provided estimates of the water content of DNA crystals and these results were consistent with the two sugar-phosphate backbones being on the outside of the molecule. Franklin told Crick and Watson that the backbones had to be on the outside; before then, Linus Pauling and Watson and Crick had erroneous models with the chains inside and the bases pointing outwards.[22] Her identification of the space group for DNA crystals revealed to Crick that the two DNA strands were antiparallel.

The X-ray diffraction images collected by Gosling and Franklin provided the best evidence for the helical nature of DNA. Watson and Crick had three sources for Franklin's unpublished data:

  1. Her 1951 seminar, attended by Watson;[47]
  2. Discussions with Wilkins,[48] who worked in the same laboratory with Franklin;
  3. A research progress report that was intended to promote coordination of
    Medical Research Council-supported laboratories.[49]
    Watson, Crick, Wilkins and Franklin all worked in MRC laboratories.

In a 1954 article, Watson and Crick acknowledged that, without Franklin's data, "the formulation of our structure would have been most unlikely, if not impossible".[50] In The Double Helix, Watson later admitted that "Rosy, of course, did not directly give us her data. For that matter, no one at King's realized they were in our hands". In recent years, Watson has garnered controversy in the popular and scientific press for his "misogynist treatment" of Franklin and his failure to properly attribute her work on DNA.[37] According to one critic, Watson's portrayal of Franklin in The Double Helix was negative, giving the impression that she was Wilkins' assistant and was unable to interpret her own DNA data.[51] Watson's accusation was indefensible since Franklin told Crick and Watson that the helix backbones had to be on the outside.[22] From a 2003 piece by Brenda Maddox in Nature:[37]

Other comments dismissive of "Rosy" in Watson's book caught the attention of the emerging women's movement in the late 1960s. "Clearly Rosy had to go or be put in her place ... Unfortunately Maurice could not see any decent way to give Rosy the boot". And, "Certainly a bad way to go out into the foulness of a ... November night was to be told by a woman to refrain from venturing an opinion about a subject for which you were not trained."

Robert P. Crease remarks that "[Franklin] was close to figuring out the structure of DNA, but did not do it. The title of "discoverer" goes to those who first fit the pieces together".[45] Jeremy Bernstein rejects that Franklin was a "victim" and states that "[Watson and Crick] made the double-helix scheme work. It is as simple as that".[45] Matthew Cobb and Nathaniel C. Comfort write that "Franklin was no victim in how the DNA double helix was solved" but that she was "an equal contributor to the solution of the structure".[50]

A review of the correspondence from Franklin to Watson, in the archives at CSHL, revealed that the two scientists later exchanged constructive scientific correspondence. Franklin consulted with Watson on her tobacco mosaic virus RNA research. Franklin's letters were framed with the normal and unremarkable forms of address, beginning with "Dear Jim", and concluding with "Best Wishes, Yours, Rosalind". Each of the scientists published their own unique contributions to the discovery of the structure of DNA in separate articles, and all of the contributors published their findings in the same volume of Nature. These classic molecular biology papers are identified as: Watson J. D. and Crick F. H. C. "A Structure for Deoxyribose Nucleic Acid". Nature 171, 737–738 (1953);[39] Wilkins M. H. F., Stokes A. R. & Wilson H. R. "Molecular Structure of Deoxypentose Nucleic Acids". Nature 171, 738–740 (1953);[52] Franklin R. and Gosling R. G. "Molecular Configuration in Sodium Thymonucleate". Nature 171, 740–741 (1953).[53]

Harvard University

In 1956, Watson accepted a position in the biology department at Harvard University. His work at Harvard focused on RNA and its role in the transfer of genetic information.[54]

Watson championed a switch in focus for the school from classical biology to molecular biology, stating that disciplines such as ecology, developmental biology, taxonomy, physiology, etc. had stagnated and could progress only once the underlying disciplines of molecular biology and biochemistry had elucidated their underpinnings, going so far as to discourage their study by students.

Watson continued to be a member of the Harvard faculty until 1976, even though he took over the directorship of Cold Spring Harbor Laboratory in 1968.[54]

During his tenure at Harvard, Watson participated in a protest against the Vietnam War, leading a group of 12 biologists and biochemists calling for "the immediate withdrawal of U.S. forces from Vietnam".[55] In 1975, on the thirtieth anniversary of the bombing of Hiroshima, Watson was one of over 2000 scientists and engineers who spoke out against nuclear proliferation to President Gerald Ford, arguing that there was no proven method for the safe disposal of radioactive waste, and that nuclear plants were a security threat due to the possibility of terrorist theft of plutonium.[56]

Watson's first textbook, The Molecular Biology of the Gene, used the concept of heads—brief declarative subheadings.

Molecular Biology of the Cell, in which he coordinated the work of a group of scientist-writers. His third was Recombinant DNA, which described the ways in which genetic engineering
has brought new information about how organisms function.

Publishing The Double Helix

In 1968, Watson wrote The Double Helix,[58] listed by the board of the Modern Library as number seven in their list of 100 Best Nonfiction books.[59] The book details the story of the discovery of the structure of DNA, as well as the personalities, conflicts and controversy surrounding their work, and includes many of his private emotional impressions at the time. Watson's original title was to have been "Honest Jim".[60] Controversy surrounded the publication of the book. Watson's book was originally to be published by the Harvard University Press, but Francis Crick and Maurice Wilkins, among others, objected. Watson's home university dropped the project and the book was commercially published.[61][62] In an interview with Anne Sayre for her book, Rosalind Franklin and DNA (published in 1975 and reissued in 2000), Francis Crick said that he regarded Watson's book as a "contemptible pack of damned nonsense".[63]

Cold Spring Harbor Laboratory

External videos
Chemical Heritage Foundation

In 1968, Watson became the director of the Cold Spring Harbor Laboratory (CSHL). Between 1970 and 1972, the Watsons' two sons were born, and by 1974, the young family made Cold Spring Harbor their permanent residence. Watson served as the laboratory's director and president for about 35 years, and later he assumed the role of chancellor and then chancellor emeritus.

In his roles as director, president, and chancellor, Watson led CSHL to articulate its present-day mission, "dedication to exploring molecular biology and genetics in order to advance the understanding and ability to diagnose and treat cancers, neurological diseases, and other causes of human suffering."[64] CSHL substantially expanded both its research and its science educational programs under Watson's direction. He is credited with "transforming a small facility into one of the world's great education and research institutions. Initiating a program to study the cause of human cancer, scientists under his direction have made major contributions to understanding the genetic basis of cancer."[65] In a retrospective summary of Watson's accomplishments there, Bruce Stillman, the laboratory's president, said, "Jim Watson created a research environment that is unparalleled in the world of science."[65]

In 2007, Watson said, "I turned against the

left wing because they don't like genetics, because genetics implies that sometimes in life we fail because we have bad genes. They want all failure in life to be due to the evil system."[66]

Human Genome Project

Watson in 1992

In 1990, Watson was appointed as the head of the

Association for Molecular Pathology v. U.S. Patent and Trademark Office
.)

In 1994, Watson became president of

Francis Collins
took over the role as director of the Human Genome Project.

Watson was quoted in The Sunday Telegraph in 1997 as stating: "If you could find the gene which determines sexuality and a woman decides she doesn't want a homosexual child, well, let her."[69] The biologist Richard Dawkins wrote a letter to The Independent claiming that Watson's position was misrepresented by The Sunday Telegraph article, and that Watson would equally consider the possibility of having a heterosexual child to be just as valid as any other reason for abortion, to emphasise that Watson is in favor of allowing choice.[70]

On the issue of obesity, Watson was quoted in 2000, saying: "Whenever you interview fat people, you feel bad, because you know you're not going to hire them."[71]

Watson has repeatedly supported genetic screening and genetic engineering in public lectures and interviews, arguing that stupidity is a disease and the "really stupid" bottom 10% of people should be cured.[72] He has also suggested that beauty could be genetically engineered, saying in 2003, "People say it would be terrible if we made all girls pretty. I think it would be great."[72][73]

In 2007, Watson became the second person[74] to publish his fully sequenced genome online,[75] after it was presented to him on May 31, 2007, by 454 Life Sciences Corporation[76] in collaboration with scientists at the Human Genome Sequencing Center, Baylor College of Medicine. Watson was quoted as saying, "I am putting my genome sequence on line to encourage the development of an era of personalized medicine, in which information contained in our genomes can be used to identify and prevent disease and to create individualized medical therapies".[77][78][79]

Later life

In 2014, Watson published a paper in

oxidants may have a different role than is thought in diseases including diabetes, dementia, heart disease and cancer. For example, type 2 diabetes is usually thought to be caused by oxidation in the body that causes inflammation and kills off pancreatic cells. Watson thinks the root of that inflammation is different: "a lack of biological oxidants, not an excess", and discusses this in detail. One critical response was that the idea was neither new nor worthy of merit, and that The Lancet published Watson's paper only because of his name.[80] Other scientists have expressed their support for his hypothesis and have proposed that it can also be expanded to why a lack of oxidants can result in cancer and its progression.[81]

In 2014, Watson sold his Nobel Prize medal to raise money after complaining of being made an "unperson" following controversial statements he had made.[82] Part of the funds raised by the sale went to support scientific research.[83] The medal sold at auction at Christie's in December 2014 for US$4.1 million. Watson intended to contribute the proceeds to conservation work in Long Island and to funding research at Trinity College, Dublin.[84][85] He was the first living Nobel recipient to auction a medal.[86] The medal was later returned to Watson by the purchaser, Alisher Usmanov.[87]

Notable former students

Several of Watson's former doctoral students subsequently became notable in their own right including, Mario Capecchi,[4] Bob Horvitz, Peter B. Moore and Joan Steitz.[5] Besides numerous PhD students, Watson also supervised postdoctoral researchers and other interns including Ewan Birney,[6] Ronald W. Davis, Phillip Allen Sharp (postdoc), John Tooze (postdoc)[8][9] and Richard J. Roberts (postdoc).[7]

Other affiliations

Watson is a former member of the Board of Directors of United Biomedical, Inc., founded by Chang Yi Wang. He held the position for six years and retired from the board in 1999.[88]

In January 2007, Watson accepted the invitation of Leonor Beleza, president of the Champalimaud Foundation, to become the head of the foundation's scientific council, an advisory organ.[89][90]

In March 2017, Watson was named head consultant of the Cheerland Investment Group, a Chinese investment company which sponsored his trip.[citation needed]

Watson has also been an institute adviser for the Allen Institute for Brain Science.[91][92]

James Watson (February 2003)

Avoid Boring People

Watson signing autographs after a speech at Cold Spring Harbor Laboratory on April 30, 2007

Watson has had disagreements with

Celera genomics and continued his feud with Watson. Watson was quoted as calling Venter "Hitler".[93]

In his 2007 memoir, Avoid Boring People: Lessons from a Life in Science, Watson describes his academic colleagues as "dinosaurs", "deadbeats", "fossils", "has-beens", "mediocre", and "vapid".

Steve Shapin in Harvard Magazine noted that Watson had written an unlikely "Book of Manners", telling about the skills needed at different times in a scientist's career; he wrote Watson was known for aggressively pursuing his own goals at the university. E. O. Wilson once described Watson as "the most unpleasant human being I had ever met", but in a later TV interview said that he considered them friends and their rivalry at Harvard "old history" (when they had competed for funding in their respective fields).[95][96]

In the epilogue to the memoir Avoid Boring People, Watson alternately attacks and defends former Harvard University president Lawrence Summers, who stepped down in 2006 due in part to his remarks about women and science.[97] Watson also states in the epilogue, "Anyone sincerely interested in understanding the imbalance in the representation of men and women in science must reasonably be prepared at least to consider the extent to which nature may figure, even with the clear evidence that nurture is strongly implicated."[73][94]

Comments on race

At a conference in 2000, Watson suggested a link between skin color and sex drive, hypothesizing that dark-skinned people have stronger libidos.[71][98] His lecture argued that extracts of melanin—which gives skin its color—had been found to boost subjects' sex drive. "That's why you have Latin lovers", he said, according to people who attended the lecture. "You've never heard of an English lover. Only an English Patient."[99] He has also said that stereotypes associated with racial and ethnic groups have a genetic basis: Jews being intelligent, Chinese being intelligent but not creative because of selection for conformity, and Indians being servile because of selection under caste endogamy.[100] Regarding intelligence differences between blacks and whites, Watson has asserted that "all our social policies are based on the fact that their (blacks) intelligence is the same as ours (whites) – whereas all the testing says not really ... people who have to deal with black employees find this not true."[101]

Watson has repeatedly asserted that differences in average measured IQ between blacks and whites are due to genetics.[102][103][104] In early October 2007, he was interviewed by Charlotte Hunt-Grubbe at Cold Spring Harbor Laboratory (CSHL). He discussed his view that Africans are less intelligent than Westerners.[105][106][107] Watson said his intention was to promote science, not racism, but some UK venues canceled his appearances,[108] and he canceled the rest of his tour.[109][110][111][112] An editorial in Nature said that his remarks were "beyond the pale" but expressed a wish that the tour had not been canceled so that Watson would have had to face his critics in person, encouraging scientific discussion on the matter.[113] Because of the controversy, the board of trustees at Cold Spring Harbor Laboratory suspended Watson's administrative responsibilities.[114] Watson issued an apology,[115] then retired at the age of 79 from CSHL from what the lab called "nearly 40 years of distinguished service".[65][116] Watson attributed his retirement to his age and to circumstances that he could never have anticipated or desired.[117][118][119]

In 2008, Watson was appointed chancellor emeritus of CSHL[120][121] but continued to advise and guide project work at the laboratory.[122] In a BBC documentary that year, Watson said he did not see himself as a racist.[123]

In January 2019, following the broadcast of a television documentary made the previous year in which he repeated his views about race and genetics, CSHL revoked honorary titles that it had awarded to Watson and cut all remaining ties with him.[124][125][126] Watson did not respond to the developments.[127]

Personal life

Watson is an atheist.[14][128] In 2003, he was one of 22 Nobel Laureates who signed the Humanist Manifesto.[129]

Marriage and family

Watson married Elizabeth Lewis in 1968.[10] They have two sons, Rufus Robert Watson (b. 1970) and Duncan James Watson (b. 1972). Watson sometimes talks about his son Rufus, who has schizophrenia, seeking to encourage progress in the understanding and treatment of mental illness by determining how genetics contributes to it.[122]

Awards and honors

James D. Watson with the Othmer Gold Medal, 2005

Watson has won numerous awards, including:

Honorary degrees received

Professional and honorary affiliations

See also

References

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  145. ^ "Statement by Cold Spring Harbor Laboratory addressing remarks by Dr. James D. Watson in "American Masters: Decoding Watson"". Cold Spring Harbor Laboratory. January 11, 2019. Retrieved January 12, 2019. In response to his most recent statements, which effectively reverse the written apology and retraction Dr. Watson made in 2007, the Laboratory has taken additional steps, including revoking his honorary titles of Chancellor Emeritus, Oliver R. Grace Professor Emeritus, and Honorary Trustee.

Further reading

Selected books published

Library resources about
James Watson
By James Watson

External links
Articles and interviews
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