James F. Crow

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James F. Crow
Phoenixville, Pennsylvania
DiedJanuary 4, 2012(2012-01-04) (aged 95)
Madison, Wisconsin
EducationFriends University, Wichita
AwardsThomas Hunt Morgan Medal (1987)
Scientific career
FieldsGenetics
InstitutionsUniversity of Wisconsin–Madison

James Franklin Crow (January 18, 1916 – January 4, 2012) was

Professor Emeritus of Genetics at the University of Wisconsin–Madison and a prominent population geneticist whose career spanned from the modern synthesis to the genomic era.[1][2][3][4][5][6]

Some of his most significant peer-reviewed contributions were coauthored with

Joe Felsenstein, Russell Lande, Dan Hartl,[6] and Wen-Hsiung Li
.

He was a president of both the Genetics Society of America and the American Society of Human Genetics. He was a member of the National Academy of Sciences, The American Philosophical Society, the World Academy of Art and Science, the National Academy of Medicine, the American Academy of Arts and Sciences, and Foreign Member of the Royal Society (ForMemRS).[6]

Biography

Early life and education

Crow was born in 1916 in

Quaker
school, also in Wichita, graduating in 1937.

At school, he enjoyed physics and chemistry, but pursued chemistry more strongly at university. He picked up biology as well, and double majored in chemistry and biology. A genetics course in his junior year was his first exposure to that field, even though the syllabus omitted the modern synthesis.

Delaying the decision of whether to become a biologist or chemist, Crow applied for graduate fellowships in both biology and biochemistry. He took up the first positive reply, a position with

those living apart
were not.

A great influence on Crow at the time was W.S. Stone, who encouraged him to learn more mathematics, while he himself knew none. Later on, Crow admitted to struggling with some of the advanced maths and physics courses he took as a result, but also said they had been rewarding.

Dartmouth College and the war

Crow graduated with his PhD in 1941 and moved to Dartmouth College just prior to the American entry into World War II, where he remained until 1948. The original plan had been to get a postdoctoral fellowship to work with Sewall Wright at the University of Chicago, but this proved difficult just at the start of the war.

His appointment in Dartmouth was to teach genetics and general

haematology. Not long after, he was also teaching statistics
. It may be that, having to teach many hours each day, Crow discovered his love for teaching at this point. He later recounted that there were several students all of whose courses were taught by him.

He, like many of his colleagues of the era, had college-time involvement with pacifist groups that had communist leanings. During WWII, he tried to enlist, but was deferred until the end due to his teaching commitments.

Race and IQ controversy

Crow wrote "Genetic Theories and Influences: Comments on the Value of Diversity," an article in the Harvard Educational Review reprinted in the review's reprint series[12] responding to Arthur Jensen's 1969 article, "How Much Can We Boost IQ and Academic Achievement?"

Paternal age effect on DNA

Crow also did research and writing in how DNA in sperm degrades as men age, through repeated copying, and can then be passed along to children in permanently degraded form, which they likely then pass on as well. As a result, he said in 1997 that the "greatest mutational health hazard to the human genome is fertile older males". He described mutations that have a direct visible effect on the child's health and also mutations that can be latent or have minor visible effects on the child's health; many such mutations allow the child to reproduce, but cause more serious problems for grandchildren, great-grandchildren and later generations[13] A 2009 review prematurely concluded that the absolute risk from paternal age for genetic anomalies in offspring was low, and stated that "there is no clear association between adverse health outcome and paternal age but longitudinal studies are needed."[14]

However, newer studies supported Crow's claims. A study in 2006 of 132,000 Israeli adolescents discovered men in their 30s are 1.6 times as likely to have a child with autism as men under 30, with men in their 40s having a sixfold increase in risk [15] Further studies in Sweden (2.6 million children),[16] Denmark (2.98 million),[17] and an international dataset of 5.7 million children [18] showed a definite link between increased paternal age and autism risk. A widely-referenced Icelandic whole-genome sequencing effort led by Kári Stefánsson of DEcode Genetics and published in Nature also concluded similarly.[19]

Research

Much of Crow’s research was in the area of theoretical population genetics, but he has often ventured into the laboratory. Over a career that spanned more than 50 years, Crow and his collaborators studied a variety of traits in Drosophila, dissected the genetics of DDT resistance, measured the effects of minor mutations on the overall fitness of populations, described the behavior of mutations that do not play the selection game by Darwin’s rules, and investigated many other subjects. His theoretical work has touched virtually every important subject in population genetics. Crow developed the concept of genetic load, has contributed to the theory of random drift in small populations, has studied the effects of non-random mating and age-structured populations, and has considered the question, “What good is sex?” He also developed ways to estimate inbreeding in human populations by making use of the way in which surnames are “inherited,” and was a world expert on the genetic effects of low level ionizing radiation. In addition to his many research publications, Crow published many reviews and appreciations of the work of his colleagues. His textbook/monograph on population genetics, written with Motoo Kimura, has had a notable impact on its field.

Public service

Crow chaired the Department of Medical Genetics for five years and the Laboratory of Genetics (Genetics plus Medical Genetics) for a total of eight years. He also served as Acting Dean of the UW Medical School for 2 years. He was President of the Genetics Society of America and the American Society of Human Genetics. He was the co-editor-in-chief of the journal GENETICS and edited its perspectives section from 1987 until 2008. Crow served at the national level as a member of the General Advisory Committee to the Director of NIH and of the executive council of the National Committee on Radiation Protection, chaired the NIH Genetics Study Section and the NIH Mammalian Genetics Study Section, and chaired several committees for the National Academy of Sciences including a committee to study forensic uses of DNA fingerprinting.[citation needed]

In addition, Crow played viola for the Madison Symphony Orchestra from 1949 to 1994 and served as President of the Madison Civic Music Society and of the Madison Symphony Orchestra. He led a fund-raising drive to establish an endowment for the Pro Arte String Quartet.[citation needed]

Crow was a member of the

congestive heart failure in 2012.[20][21]

Personal life

Crow was married to Ann Crockett.[22] They are survived by a son, the computer scientist Franklin C. Crow; two daughters, Laura and Catherine; six grandchildren and two great-grandchildren.[23] He was an atheist and an opponent of the intelligent design movement.[24]

Death

James F. Crow died on January 4, 2012, at age 95 from congestive heart failure at his home in Madison, Wisconsin.[25]

Selected publications

References

  1. PMID 22281585
    .
  2. PMID 22219505
    .
  3. PMID 22174181
    .
  4. PMID 22174180
    .
  5. PMID 16700058
    .
  6. ^
    doi:10.1098/rsbm.2014.0004
    .
  7. PMID 16592610
    .
  8. PMID 282633
    .
  9. PMID 5012689
    .
  10. PMID 14156929
    .
  11. PMID 14071753
    .
  12. ^ Crow, James F. (1969). "Genetic Theories and Influences: Comments on the Value of Diversity". In Harvard Educational Review (ed.). Environment, Heredity, and Intelligence. Reprint Series No. 2. Cambridge (MA): Harvard Educational Review. pp. 153–161.
  13. PMID 9237985
    .
  14. ISBN 9781906985134
    . Retrieved 2018-07-08.
  15. PMID 16953005
    .
  16. PMID 24577047
    .
  17. PMID 24452535
    .
  18. PMID 26055426
    .
  19. PMID 22914142
    .
  20. ISSN 0362-4331
    . Retrieved 2023-02-17.
  21. S2CID 42676042
    .
  22. ^ http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/crow-james.pdf [bare URL PDF]
  23. ^ "News and Events".
  24. ^ "James F. Crow dies". NCSE. January 5, 2012. Retrieved 21 April 2012. In his published work, Crow seems not to have mentioned the creationism/evolution controversy at all. But he was deeply concerned with the integrity of science education nevertheless. In a June 1–3, 2005, interview with the Oral History of Human Genetics Project, he was asked how he felt about the persistence of the antievolutionist movement despite the continued advances in understanding evolution. "I am puzzled by this," he answered, adding, "I'm especially puzzled by literate, intelligent, often scientifically trained people who are into intelligent design. ... The argument of so-called irreducible complexity that the intelligent design people make such a to-do over, I think that's a non-issue. ... That to me is a very, very old argument. I'd say the elephant trunk is complicated, too, and a lot more complicated than the bacterial flagellum. So what's new in this argument?" Reiterating "I am worried about creationism," he offered his view about science and religion: "My own views are atheistic, but I don't go around preaching atheism.
  25. ISSN 0362-4331
    . Retrieved 2016-01-24.
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