Jay McLean

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Jay McLean
Jay Mclean
Born
San Francisco, California, United States
Died
Savannah, Georgia, United States
Known forHeparin
Medical career
ProfessionPhysician

Jay McLean (1890 – November 14, 1957) was an American surgeon. He is most notable for his major contribution to the discovery of heparin.

Early life

Born in

University of California at Berkeley in 1909, obtaining his Bachelor of Science degree in 1914.[1]

Career

McLean moved to

cephalin or if cephalin itself had a naturally pro-coagulating effect and to compare it to other phosphatides.[2][1] In 1916, when McLean was a second-year medical student, he was investigating pro-coagulant compounds when he first isolated a fat-soluble phosphatide anti-coagulant.[3] This anti-coagulant was first isolated from the liver tissue of canines, which is how Heparin got its name(hepar or "ήπαρ" is Greek for "liver"; hepar + -in), first coined in 1918.[4] Following the departure of McLean, Howell continued his work and with the assistance of T. Emmett Holt he isolated a water-soluble polysaccharide anticoagulant.[5] Howell also coined 'heparin' as the name of this compound despite being different from the compound previously discovered by McLean.[6]

McLean graduated from Johns Hopkins in 1919 and began an internship at the Johns Hopkins Hospital.[5] Following completion of his internship, he began a surgical residency, in which he rotated through the Hunterian Laboratory, the laboratory founded by Harvey Cushing in 1904.[7]

McLean stayed in Baltimore until 1924 when returned to his alma-mater, the University of California to become an instructor in surgery.[5] After three years in California, McLean took a position in the Department of Pathology at Cornell University, a position which he held until 1939.[5] After leaving Cornell, McLean moved to Columbus, Ohio, where he worked in private surgical practice and was appointed as an associate professor of surgery at Ohio State medical school.[5] In 1949, he was appointed director of Radiation Therapy and Consultant in Malignant Diseases in Savannah, Georgia, where he remained until his death in 1957, aged 67 years.[5] 6 years after McLean passed away he was awarded a plaque by the Upjohn Company to Johns Hopkins School of Medicine for his work in the discovery of heparin as a second-year medical student.[5]

References

  1. ^
    PMID 13619023
    .
  2. ^
    S2CID 2581961
    .
  3. doi:10.1152/ajplegacy.1916.41.2.250
    .
  4. PMID 8281678.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  5. ^
    PMID 2664233
    .
  6. ^ "ajplegacy.physiology.org".
  7. PMID 10626949
    .
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