Jeannie T. Lee
Jeannie T. Lee | |
---|---|
Alma mater | Harvard University, University of Pennsylvania Medical School, Massachusetts Institute of Technology |
Awards | 2018 Harrington Rare Genetic Disease Scholar
2016 Lurie Award 2016 Centennial Award from Genetics Society of America 2015 Election to National Academy of Sciences (NAS) 2010 Molecular Biology Award from NAS 1999 Pew Scholar 1998 Basil O'Connor Scholar |
Scientific career | |
Fields | epigenetics, long noncoding RNA, X-inactivation, 3D genome, X-chromosome reactivation technology |
Thesis | (1993) |
Academic advisors | Nancy Kleckner, Robert Nussbaum, Rudolf Jaenisch |
Jeannie T. Lee is a Professor of Genetics (and Pathology) at Harvard Medical School and the Massachusetts General Hospital, and a Howard Hughes Medical Institute Investigator. She is known for her work on X-chromosome inactivation and for discovering the functions of a new class of epigenetic regulators known as long noncoding RNAs (lncRNAs), including Xist and Tsix.
Education
Jeannie T. Lee received an AB from
Research career
Lee joined the faculty at Harvard in 1997 and devoted her studies to noncoding RNA and sex chromosome dynamics during development and disease. Her major career research achievements include identifying the X inactivation center,[5][6] discovering Tsix antisense RNA,[7] determining Xist's mechanism of action,[8][9] demonstrating that a lncRNA is a regulator of Polycomb repressive complex 2,[8][10][11][12] and determining that the X chromosome folds like origami and adopts a unique conformation.
Her studies established the existence and function of a group of lncRNAs. In a 2013 interview, she stated that this group of RNAs excited her because they control gene expression in a locus-specific way, by recruiting chromatin modifying activities to the locus, making the lncRNAs excellent drug design targets. She founded RaNA Therapeutics to test this idea.[3]
Upon conferring the
Lee was President of the Genetics Society of America,[14] Codirector of the Harvard Epigenetics Initiative, and is Vice Chair of the Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School. She delivered a set of lectures to iBiology on X chromosome inactivation.[15]
Notable publications
- Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. J Zhao, BK Sun, JA Erwin, JJ Song, JT Lee. Science, 2008 [8]
- Long noncoding RNAs: past, present, and future. JTY Kung, D Colognori, JT Lee. Genetics, 2013 [16]
- Epigenetic regulation by long noncoding RNAs. JT Lee. Science, 2012 [17]
- Genome-wide identification of polycomb-associated RNAs by RIP-seq. J Zhao, T Ohsumi, ... JT Lee. Molecular Cell, 2010 [18]
- YY1 tethers Xist RNA to the inactive X nucleation center. Y Jeon, JT Lee. Cell, 2011 [19]
- Transient homologous chromosome pairing marks the onset of X inactivation. N Xu, CL Tsai, JT Lee. Science, 2006 [20]
- Tsix, a gene antisense to Xist at the X-inactivation centre. JT Lee, LS Davidow, D Warshawsky. Nature Genetics, 1999 [7]
- A 450 kb transgene displays properties of the mammalian X-inactivation center. JT Lee, WM Strauss, JA Dausman, R Jaenisch. Cell, 1996 [21]
Awards
- 1998 Basil O'Connor Scholar Award
- 2000 Pew Scholar[22]
- 2010 Elected Fellow of the American Association for the Advancement of Science (AAAS)
- 2010 Molecular Biology Award from the National Academy of Sciences
- 2011 NIH MERIT Award
- 2014 Distinguished Graduate Award of the University of Pennsylvania Perelman School of Medicine
- 2015 Elected member of the National Academy of Sciences[14]
- 2016 Centennial Award from GENETICS, Genetics Society of America[23]
- 2016 Lurie Prize in Biomedical Sciences from the Foundation for the National Institutes of Health
- 2018 Harrington Rare Genetic Disease Scholar
References
- ^ "Jeannie T. Lee". Massachusetts General Hospital. Retrieved August 15, 2018.
- ^ "Jeannie T. Lee".
- ^ a b c "Interview with Jeannie T. Lee". Oligonucleotide Therapeutics Society. August 13, 2016.
- PMID 26582793.
- S2CID 17888183.
- PMID 10097124.
- ^ S2CID 30636065.
- ^ PMID 18974356.
- PMID 26089354.
- PMID 21172659.
- PMID 24882207.
- PMID 27984727.
- ^ "Foundation for the NIH to Award Lurie Prize in Biomedical Sciences to Dr. Jeannie Lee for Pioneering Work in Epigenetics | FNIH". fnih.org. Archived from the original on 2017-09-30. Retrieved 2017-09-30.
- ^ a b "Jeannie T. Lee".
- ^ "Jeannie Lee • iBiology". iBiology. Retrieved 2019-12-15.
- PMID 23463798.
- S2CID 206546141.
- PMID 21172659.
- PMID 21729784.
- S2CID 20362477.
- S2CID 17888183.
- ^ "Interview with Jeannie T. Lee, MD, PHD". 6 August 2013. Archived from the original on 19 April 2017. Retrieved 18 April 2017.
- ^ "Centennial Awards honor outstanding GENETICS articles". EurekAlert!. Retrieved 2017-09-30.