John E. Walker
Rastrick Grammar School | |
---|---|
Alma mater | University of Oxford (BA, DPhil) |
Spouse |
Christina Westcott (m. 1963) |
Children | Two |
Awards |
|
Scientific career | |
Institutions | Laboratory of Molecular Biology University of Cambridge |
Thesis | Studies on naturally occurring peptides (1970) |
Doctoral advisor | Edward Abraham[4] |
Website | www |
Sir John Ernest Walker FRS FMedSci[3] (born 7 January 1941) is a British chemist who won the Nobel Prize in Chemistry in 1997.[6] As of 2015[update] Walker is Emeritus Director and Professor at the MRC Mitochondrial Biology Unit in Cambridge, and a Fellow of Sidney Sussex College, Cambridge.[7][8][9][10][11]
Early life and education
Walker was born in
Career and research
From 1969 to 1971, Walker worked at the
His landmark crystallographic studies of the F1-ATPase, the catalytic region of the ATP synthase (done in collaboration with crystallographer Andrew Leslie), from bovine heart mitochondria revealed the three catalytic sites in three different conformations imposed by the position of the asymmetric central stalk. This structure supported the binding change mechanism and rotary catalysis for the ATP synthase (and related enzymes), one of the catalytic mechanisms proposed by Paul Boyer. This work, published in 1994, led to Walker's share of the 1997 Nobel prize for chemistry. Since this structure, Walker and his colleagues have produced most of the crystal structures in the PDB of mitochondrial ATP synthase, including transition state structures and protein with bound inhibitors and antibiotics. Scientists trained in Walker's group at the MRC Laboratory of Molecular Biology in Cambridge or MRC Mitochondrial Biology Unit have gone on to determine crystal bacterial complex I and cryo-EM maps of mitochondrial complex I and vacuolar type ATPases.
Teaching and mentoring
Many students and
Awards and honours
Walker was elected an
Personal life
Walker married Christina Westcott in 1963, and has two daughters.[2]
References
- ^ a b "John E. Walker". people.embo.org. EMBO.
- ^ a b "WALKER, Prof. John Ernest". Who's Who. Vol. 1996 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
- ^ a b c d Anon (1995). "Sir John Walker FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.
{{cite web}}
: CS1 maint: bot: original URL status unknown (link) - ^ ]
- ^ "John E. Walker – Facts".
- ^ "The Nobel Prize in Chemistry 1997".
- ^ John Walker interviewed by Alan Macfarlane 14 January 2008 (film)
- ^ Freeview Video of Fredrick Sanger in conversation with John Walker by the Vega Science Trust
- ^ A three part video interview with Sir John Walker by the Vega Science Trust
- PMID 6329717.
- ^ John E. Walker publications indexed by the Scopus bibliographic database. (subscription required)
- ^ a b "John Walker – Curriculum vitae – Mitochondrial Biology Unit". cam.ac.uk.
- ^ John E. Walker on Nobelprize.org , accessed 29 April 2020
- PMID 24380948.
- ^ "Advisory Council of the Campaign for Science and Engineering". Archived from the original on 28 August 2010. Retrieved 11 February 2011.
- ^ "John Walker – Honours and Awards – Mitochondrial Biology Unit". cam.ac.uk.
- ^ Anon. "J.E. Walker". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 14 February 2016. Retrieved 14 February 2016.
This article incorporates text available under the CC BY 4.0 license.