John Vane

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John Robert Vane
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For the Australian bushranger, see John Vane (bushranger). For the British peer, see John Vane, 11th Baron Barnard.

Sir John Vane
Born
John Robert Vane

(1927-03-29)29 March 1927
Tardebigge, Worcestershire, England
Died19 November 2004(2004-11-19) (aged 77)
Kent, England
CitizenshipUnited Kingdom
Alma mater
Known for
Spouse
Elizabeth Daphne Page
​
​
(m. 1948)​
Awards
Scientific career
FieldsPharmacology
Institutions
ThesisBlood flow and its relation to secretion in the stomach and smaller intestine (1952)
Doctoral advisorGeoffrey S. Dawes

Sir John Robert Vane

Sune Bergström and Bengt Samuelsson for "their discoveries concerning prostaglandins and related biologically active substances".[2]

Education and early life

Born in Tardebigge, Worcestershire, John Vane was one of three children and grew up in suburban Birmingham. His father, Maurice Vane, was the son of Jewish Russian immigrants[3] and his mother, Frances Vane, came from a Worcestershire farming family.[2] He attended a local state school from age 5, before moving on to King Edward's School in Edgbaston, Birmingham. An early interest in chemistry was to prove the inspiration for studying the subject at the University of Birmingham in 1944.

During his undergraduate studies, Vane became disenchanted with chemistry but still enjoyed experimentation. When Maurice Stacey, the Professor of Chemistry at Birmingham, was asked by Harold Burn to recommend a student to go to Oxford and study pharmacology, Vane jumped at the chance and moved to Burn's department in 1946. Under Burn's guidance, Vane found motivation and enthusiasm for pharmacology, writing: "[the] laboratory gradually became the most active and important centre for pharmacological research in the U.K. and the main school for training of young pharmacologists."[2] Vane completed a Bachelor of Science degree in pharmacology and briefly went to work at the University of Sheffield,[citation needed] before coming back to Oxford to complete his Doctor of Philosophy degree in 1953[4] supervised by Geoffrey Dawes.[5]

Career and research

After completing his DPhil, Vane worked as an assistant professor the Department of Pharmacology at Yale University before moving back to the United Kingdom to take up a post as a senior lecturer in the Institute of Basic Medical Sciences at the University of London in 1955.[6][7]

University of London

John Vane and Salvador Moncada in the 1960s

Vane held a post at the University of London for 18 years, progressing from senior lecturer to Professor of Experimental Pharmacology in 1966 (at the Royal College of Surgeons). During that time he developed certain bioassay techniques and focussed his research on both angiotensin-converting enzyme and the actions of aspirin, eventually leading to the publication with Priscilla Piper of the relationship between aspirin and the prostaglandins that earned him the Nobel Prize in Physiology or Medicine in 1982.[8][9][10][11]

Wellcome Foundation

In 1973, Vane left his academic post at the Royal College of Surgeons and took up the position as Director of Research at the

Wellcome Foundation, taking a number of his colleagues with him who went on to form the Prostaglandin Research department. Under the leadership of Salvador Moncada, this group continued important research that eventually led to the discovery of prostacyclin.[6]

Return to academia

In 1985, Vane returned to academic life and founded

vascular function.[6]

Awards and honours

Vane was elected a

Mount Sinai School of Medicine in 1980 and the University of Aberdeen in 1983.[2] He was awarded the Lasker Award in 1977 for the discovery of prostacyclin and was knighted in 1984 for his contributions to science. In 2000, Vane received the Golden Plate Award of the American Academy of Achievement.[14]

Personal life

John Vane married, in 1948, (Elizabeth) Daphne Page and had 2 daughters. He died on 19 November 2004 in Princess Royal University Hospital, Kent, from long-term complications arising from leg and hip fractures he sustained in May of that year.[15] Lady Vane died in 2021.[16]

See also

References

  1. ^
    S2CID 38582901
    .
  2. ^ a b c d John R. Vane on Nobelprize.org Edit this at Wikidata, accessed 12 October 2020
  3. ^ According to an interview published in Candid Science II, by István Hargittai (Imperial College Press, London, 2002, p. 562).
  4. ^ Vane, John Robert (1952). Blood flow and its relation to secretion in the stomach and smaller intestine (DPhil thesis). University of Oxford.
  5. PMID 11623979
    .
  6. ^ a b c "Sir John R. Vane FRS, Nobel Laureate (1927–2004)" Archived 27 January 2013 at the Wayback Machine. William Harvey Research Foundation.
  7. Microsoft Academic
  8. PMID 1149792
    .
  9. PMID 4199867
    .
  10. PMID 5284362
    .
  11. PMID 5284360
    .
  12. Queen Mary, University of London
    , UK. Retrieved 7 January 2012.
  13. ^ "Queen Mary, University of London Notable Alumni and Staff". Archived from the original on 12 December 2007. Retrieved 23 September 2007.
  14. American Academy of Achievement
    .
  15. ^ Obituary:Sir John Vane. guardian.co.uk. 25 November 2004.
  16. ^ VANE Lady, (Elizabeth) Daphne (née Page)

External links

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