Juan Carlos Izpisua Belmonte

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Juan Carlos Izpisua Belmonte
Born	1960 (age 63–64) Hellín, Albacete, Spain
Nationality	Spanish
Alma mater	University of Valencia University of Bologna
Scientific career
Fields	Biochemistry

Juan Carlos Izpisua Belmonte (born December 12, 1960, in Hellín, Albacete) is a Spanish biochemist and developmental biologist. He is a professor in the Gene Expression Laboratories at the Salk Institute for Biological Studies in La Jolla, California since 1993.

Education

Izpisua Belmonte graduated from the University of Valencia, Spain with a bachelor's degree in Pharmacy and Science. He then earned a master's degree in pharmacology from the same university before moving on to complete his Ph.D. in Biochemistry and Pharmacology at the University of Bologna, Italy and the University of Valencia, Spain. He followed that with a stage as a postdoctoral fellow in different institutions, including the European Molecular Biology Laboratory (EMBL), in Heidelberg, Germany and University of California, Los Angeles (UCLA), Los Angeles, USA prior to moving to the Salk Institute in 1993.^[1]

Career

In 2004, Izpisua Belmonte helped to establish the Center for Regenerative Medicine in Barcelona and was its Director between 2004 and 2014.^[1][2]

He works as a specialist at Altos Labs. In 2023, due to the interest generated by his work, one of his presentations in Boston drew such a large crowd that it violated the fire code and was reduced by the police. A biologist has cautioned against "hype" and recommended waiting for more scientific publications.^[3]

Research and claims

Izpisua Belmonte is a main catalyzer in one of today's most promising areas of

His conceptual discoveries and methodologies for regenerative medicine include:

• Elucidating some of the key cellular and molecular bases of how an organism with millions of cells develops from a single cell embryo after fertilization.^{[7][8][9][10][11][12][13]}
• Seminal discoveries towards understanding the molecular basis underlying somatic cell reprogramming
• New methodologies for the differentiation of human
  organoids, like the kidney and heart.^{[14][13][15][16]}
• Development of novel stem cell models of human
  aging and aging-associated diseases, and discovery of new drivers of rejuvenation.^[14][17][18]
• Novel genetic and
  epigenetic technologies to both treat, and prevent the transmission, of mitochondrial and nuclear DNA originated diseases.^{[14][19][20][21]}
• Proof of concept that iPSC technology can be used for the generation of disease corrected patient specific cells with potential value for cell therapy.[22]
• The development of methodologies for culturing embryos, including non-human primates, and creating synthetic mammalian embryos.^[23][24]
• Development of technologies that allow differentiation of human cells inside embryos of different species. These results may allow for the generation of human tissues and organs.^{[25][26][27][28]}

Recognition

A secondary school, Instituto Enseñanza Secundaria (IES) Izpisua Belmonte, was named after Izpisua Belmonte in his hometown of

• Chimera (genetics)
• Gene therapy
• Genome editing
• Regeneration
• Xenotransplantation

References

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