Juvenile myoclonic epilepsy
Juvenile myoclonic epilepsy | |
---|---|
Other names | Janz syndrome |
Specialty | Neurology |
Juvenile myoclonic epilepsy (JME), also known as Janz syndrome or impulsive petit mal, is a form of hereditary,
Epidemiology
The prevalence of JME is approximately 0.1–0.2 per 1,000, constituting approximately 5–10% of all epilepsies.
Signs and symptoms
There are three principal seizure types which may occur in JME: myoclonus, generalized tonic–clonic seizures and absence seizures. Approximately one-third of patients have all three seizure types.[13] The majority of patients (58.2%) have frequent myoclonic jerks,[13] with some sources stating that all patients with JME have myoclonic seizures.[10] Generalized tonic–clonic seizures are less common[13] but still reported in 85–90%.[10] Absence seizures are believed to be least common, with an estimated prevalence between 10% and 40%.[13][10][14] Seizures associated with JME tend to take place 30 minutes to an hour after waking up in the morning.[10] Common triggers for JME seizures include lack of sleep, alcohol consumption, emotional stress, anxiety, and fatigue. A notable portion (30%–40%) of JME patients exhibit photosensitivity, whereby flashing lights from sources like sunlight, TV screens, and computers can provoke seizures. Individuals with photosensitivity tend to experience seizures at an earlier stage.[10] Myoclonic status epilepticus may occur as a complication but is uncommon.
Patients typically present to medical providers following their first generalized tonic–clonic seizure, by which time they have often had myoclonus for several years. The first generalized tonic–clonic seizure usually occurs in the context of a particular provoking factor, such as sleep deprivation, stress or alcohol consumption.[15] Other potential provoking factors include "praxis induction" which is the precipitation of seizures or epileptiform discharges in the context of a complex cognitive tasks.[16] Patients with JME tend to perform worse on neuropsychological assessments in multiple cognitive domains and are also more likely to have psychiatric comorbidities such as depression and anxiety when compared to control populations.[17][18][19] The majority of patients with JME report satisfaction with their health, work, friendships and social life.[9]
Cause
JME is believed to be caused most often by multiple interacting genes rather than by a single genetic cause.
The majority of identified genes associated with JME encode for ion channel subunits.[22] More recently, variants in intestinal cell kinase, which is encoded by a gene at chromosomal locus 6p12, were found to be associated with JME. This gene is involved in mitosis, cell-cycle exit and radial neuroblast migration, as well as apoptosis.[23] EFHC1 has similar functions and is also associated with JME.[24] These findings may explain subtle structural and functional brain abnormalities seen in patients with JME.[25]
JME is distinct from other forms of genetic generalized epilepsy due to the prominence of myoclonus. There is evidence that patients with JME have hyperexcitable motor cortexes, most pronounced in the morning and after sleep deprivation.[26][27] In addition, there is evidence that patients with JME have hyperexcitable and hyperconnected cortical networks that are involved in ictogenesis.[28]
Genetics
CACNB4
CACNB4 is a gene that encodes the calcium channel β4 subunit protein. It has been associated with JME though it is not strictly considered a putative JME gene because its mutation did not segregate in affected family members, it was found in only one member of a JME family from Germany, and the finding has not been replicated.[29]
β subunits are important regulators of calcium channel current amplitude, voltage dependence, and they also regulate channel trafficking.[30] In mice, a naturally occurring null mutation leads to the "lethargic" phenotype. This is characterized by ataxia and lethargic behavior at early stages of development followed within days by the onset of focal motor seizures and episodes of behavioral immobility correlated with patterns of cortical spike and wave discharges on electroencephalography (EEG)[31] A premature-termination mutation, R482X, was identified in a patient with JME while an additional missense mutation C104F was identified in a German family with generalized epilepsy and praxis-induced seizures.[32] The R482X mutation causes increased current amplitudes and an accelerated fast time constant of inactivation.[33] Whether these modest functional differences may be in charge of JME remains to be established.[33]
GABRA1
GABRD
GABRD encodes the δ subunit of the GABA receptor, which is an important constituent of the GABAA receptor mediating tonic inhibition in neurons (extrasynaptic GABA receptors, i.e. receptors located outside the synapse).[36] Among the mutations that have been reported in this in this gene, one (R220H) has been identified in a small family with JME. This mutation affects GABAergic transmission by altering the surface expression of the receptor as well as reducing the channel opening duration.
Myoclonin1/EFHC1
Myoclonin1/EFHC1 encodes for a protein involved in cell division, neuroblast migration and synapse/dendrite formation. EFHC1 is expressed in many tissues, including the brain, where it is localized to the soma and dendrites of neurons, particularly the hippocampal CA1 region, pyramidal neurons in the cerebral cortex, and Purkinje cells in the cerebellum.[24]
There are four JME-causing mutations discovered (D210N, R221H, F229L and D253Y). The mutations do not seem to alter the ability of the protein to colocalize with centrosomes and mitotic spindles but induce mitotic spindle defects. Moreover, the mutations impact radial and tangential migration during brain development.[24] As such a theory has been put forward that JME may be the result of a brain developmental disorder.[24]
Other loci
Three SNP alleles in BRD2, Cx-36 and ME2 and microdeletions in 15q13.3, 15q11.2 and 16p.13.11 also contribute risk to JME.[37]
Diagnosis
Diagnosis is typically made based on patient history. Physical examination is usually normal.[10] Misdiagnosis can occur if myoclonic seizures mistaken for muscle twitches or feelings of anxiety/nervousness.[10]
The primary diagnosis for JME is a good knowledge of patient history and the
Both
Management
The most effective anti-epileptic medication for JME is
History
The first citation of JME was made in 1857 when Théodore Herpin described a 13-year-old boy with myoclonic jerks, which progressed to tonic–clonic seizures three months later.[46] In 1957, Janz and Christian published a journal article describing several patients with JME.[47] The name Juvenile Myoclonic Epilepsy was proposed in 1975 and adopted by the International League Against Epilepsy.[46]
Culture
Stand-up comedian Maisie Adam has JME and discussed it in her award-winning show "Vague".[48]
The 2018 documentary film Separating The Strains dealt with the use of
See also
- Progressive myoclonus epilepsies
- Spinal muscular atrophy with progressive myoclonic epilepsy
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- ^ a b Juvenile Myoclonic Epilepsy at eMedicine
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- ^ "Comedian Maisie Adam shares her experiences growing up with epilepsy in her new show Vague Epilepsy Action". www.epilepsy.org.uk.
- ^ "Cannabis documentary about epilepsy to foster more understanding". 2018-06-13.