KIR2DL1

Source: Wikipedia, the free encyclopedia.
KIR2DL1
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_014218

n/a

RefSeq (protein)

NP_055033

n/a

Location (UCSC)Chr 19: 54.77 – 54.78 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene.[3][4][5]

Function

leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.[5]

Interactions

KIR2DL1 has been shown to

See also

References

  1. ^ a b c ENSG00000275196, ENSG00000278805, ENSG00000125498, ENSG00000284401, ENSG00000278755, ENSG00000278495, ENSG00000278738, ENSG00000278248, ENSG00000278503, ENSG00000284530, ENSG00000276820, ENSG00000275080, ENSG00000275276, ENSG00000273794, ENSG00000276625, ENSG00000277616, ENSG00000284100, ENSG00000284514, ENSG00000283723, ENSG00000274926, ENSG00000278207, ENSG00000274782, ENSG00000284347, ENSG00000273510, ENSG00000274692, ENSG00000277833, ENSG00000276310, ENSG00000284551, ENSG00000275750, ENSG00000275522, ENSG00000277356, ENSG00000284145 GRCh38: Ensembl release 89: ENSG00000278821, ENSG00000275196, ENSG00000278805, ENSG00000125498, ENSG00000284401, ENSG00000278755, ENSG00000278495, ENSG00000278738, ENSG00000278248, ENSG00000278503, ENSG00000284530, ENSG00000276820, ENSG00000275080, ENSG00000275276, ENSG00000273794, ENSG00000276625, ENSG00000277616, ENSG00000284100, ENSG00000284514, ENSG00000283723, ENSG00000274926, ENSG00000278207, ENSG00000274782, ENSG00000284347, ENSG00000273510, ENSG00000274692, ENSG00000277833, ENSG00000276310, ENSG00000284551, ENSG00000275750, ENSG00000275522, ENSG00000277356, ENSG00000284145 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. PMID 7749980
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  4. .
  5. ^ a b "Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1".
  6. PMID 12454284
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  7. .
  8. .
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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.