KLF14
| KLF14 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 7: 130.73 – 130.73 Mb | Chr 6: 30.93 – 30.94 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.[5] The corresponding Klf14 mouse gene is known as Sp6.[6]
Function
KLF14 is a member of the
KLF14 appears to be a
Protein structure
Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.[11]
Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;[11] in the mouse its length is 325.[12]
Clinical significance
There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.[13][14]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000266265 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073209 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Klf14 Kruppel-like factor 14 [Mus musculus] - Gene result".
- ^ "Sp6 trans-acting transcription factor 6 [Mus musculus] - Gene result".
- PMID 19088080.
- PMID 20511139.
- PMID 17480121.
- PMID 21572415.
- ^ a b "Krüppel-like factor 14". Human Protein Reference Database. Johns Hopkins University. Retrieved 2011-05-18.
- ^ Online Mendelian Inheritance in Man (OMIM): Krüppel-like factor 14 - 609393
- PMID 20581827.
- PMID 20886378.
External links
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