KLK2

KLK2
Available structures
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	extracellular region; extracellular exosome; secretory granule;
Biological process	extracellular matrix disassembly; proteolysis; regulation of systemic arterial blood pressure; zymogen activation;
	Sources:Amigo / QuickGO
	ENSG00000167751
	n/a
	P20151
	n/a
	NM_001002231; NM_001002232; NM_001256080; NM_005551
	n/a
	NP_001002231; NP_001243009; NP_005542
	n/a
	Wikidata
View/Edit Human

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.^[3]^[4]^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167751 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
S2CID 37763337
.

S2CID 436200
.

S2CID 83910246
.

^ "Entrez Gene: KLK2 Kallikrein-related peptidase 2".

Further reading

Riegman PH, Vlietstra RJ, van der Korput HA, Romijn JC, Trapman J (1992). "Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species". Mol. Cell. Endocrinol. 76 (1–3): 181–190.
S2CID 29689514
.

Qin H, Kemp J, Yip MY, Lam-Po-Tang P, Morris BJ (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Hum. Hered. 41 (4): 222–226.
PMID 1783409
.

Schedlich LJ, Bennetts BH, Morris BJ (1988). "Primary structure of a human glandular kallikrein gene". DNA. 6 (5): 429–437.
PMID 2824146
.

Frenette G, Deperthes D, Tremblay RR, Lazure C, Dubé JY (1997). "Purification of enzymatically active kallikrein hK2 from human seminal plasma". Biochim. Biophys. Acta. 1334 (1): 109–15.
PMID 9042371
.

Bourgeois L, Brillard-Bourdet M, Deperthes D, Juliano MA, Juliano L, Tremblay RR, Dubé JY, Gauthier F (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". J. Biol. Chem. 272 (47): 29590–29595.
PMID 9368023
.

Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (1998). "Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors". Prostate. 34 (1): 44–50.
S2CID 23179822
.

Yu DC, Sakamoto GT, Henderson DR (1999). "Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy". Cancer Res. 59 (7): 1498–504.
PMID 10197620
.

Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (1999). "Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1". Int. J. Cancer. 81 (3): 438–442.
PMID 10209959
.

Lövgren J, Valtonen-André C, Marsal K, Lilja H, Lundwall A (1999). "Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids". J. Androl. 20 (3): 348–55.
PMID 10386814
.

Cargill M, Altshuler D, Ireland J, Ireland J, Sklar P, Ardlie K, Patil N, Lane CR, Lim EP (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–238.
S2CID 195213008
.

Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–789.
PMID 10411640
.

Mikolajczyk SD, Millar LS, Marker KM, Rittenhouse HG, Wolfert RL, Marks LS, Charlesworth MC, Tindall DJ (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30.
PMID 10463585
.

Liu XF, Essand M, Vasmatzis G, Lee B, Pastan I (1999). "Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing". Biochem. Biophys. Res. Commun. 264 (3): 833–839.
PMID 10544017
.

Ren F, Zhang S, Mitchell SH, Butler R, Young CY (2000). "Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells". Oncogene. 19 (15): 1924–1932.
PMID 10773882
.

Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–37406.
PMID 10969073
.

Chen VC, Chao L, Chao J (2001). "A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein". J. Biol. Chem. 275 (51): 40371–40377.
PMID 10991942
.

Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130.
PMID 11054574
.

Réhault S, Monget P, Mazerbourg S, Tremblay R, Gutman N, Gauthier F, Moreau T (2001). "Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3". Eur. J. Biochem. 268 (10): 2960–2968.
PMID 11358513
.

Saedi MS, Zhu Z, Marker K, Liu RS, Carpenter PM, Rittenhouse H, Mikolajczyk SD (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer. 94 (4): 558–563.
S2CID 2826757
.

External links

The MEROPS online database for peptidases and their inhibitors: S01.161

Overview of all the structural information available in the PDB for UniProt: P20151 (Human Kallikrein-2) at the PDBe-KB.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.
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Retrieved from "https://en.wikipedia.org/w/index.php?title=KLK2&oldid=1199468587"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167751 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2468530-3] S2CID 37763337
.

[pmid16800724-4] S2CID 436200
.

[pmid16800723-5] S2CID 83910246
.

[6] "Entrez Gene: KLK2 Kallikrein-related peptidase 2".

[2]

[3]

[4]

[5]

[6]