KLK7
| KLK7 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 50.98 – 50.98 Mb | Chr 7: 43.46 – 43.47 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Kallikrein-related peptidase 7 (KLK7) is a
Gene
Alternative splicing of the KLK7 gene results in two transcript variants encoding the same protein.[8]
Function
KLK7 is secreted as an inactive
Once active, KLK7 is able to cleave
Both KLK5 and KLK14, other skin-expressed proteases, also cleave corneodesmosomal proteins.[13] KLK5 is able to undergo autoactivation, as well as activating KLK7 and KLK14, suggesting a KLK skin cascade is responsible for coordinating desquamation.[12]
KLK7 activity is regulated by a number of endogenous protein
KLK7 is a chymotrypsin-like serine protease, preferring to cleave proteins at the residues tyrosine, phenylalanine or leucine.[20] Analysis of peptide substrate hydrolysis indicates a strong preference for tyrosine at P1.[21]
Clinical significance
Skin disease
Dysregulation of KLK7 has been linked to several skin disorders including atopic dermatitis,[22][23] psoriasis[24] and Netherton syndrome.[25][26] These diseases are characterised by excessively dry, scaly and inflamed skin, due to a disruption of skin homeostasis and correct barrier function.
Cancer
Overexpression of KLK7 may provide a route for
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169035 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030713 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8034709.
- S2CID 436200.
- S2CID 83910246.
- ^ a b "Entrez Gene: KLK7 kallikrein-related peptidase 7".
- PMID 1685827.
- PMID 10974542.
- PMID 20657595.
- ^ PMID 15654974.
- ^ PMID 15140227.
- PMID 35900871.
- PMID 17596512.
- S2CID 42775195.
- PMID 20667819.
- ^ PMID 8702990.
- PMID 16298998.
- PMID 7794273.
- PMID 16740631.
- S2CID 866377.
- PMID 15191543.
- S2CID 37395502.
- S2CID 11404025.
- PMID 16628198.
- PMID 12738725.
- S2CID 5692357.
- S2CID 8142528.
- PMID 15297163.
- PMID 21193224.
- PMID 15766562.
Further reading
- Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130. PMID 11054574.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. PMID 12477932.
- Diamandis EP, Scorilas A, Kishi T, Blennow K, Luo LY, Soosaipillai A, et al. (March 2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia". Clinical Biochemistry. 37 (3): 230–237. PMID 14972646.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–2127. PMID 15489334.
- Ishida-Yamamoto A, Deraison C, Bonnart C, Bitoun E, Robinson R, O'Brien TJ, et al. (February 2005). "LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum". The Journal of Investigative Dermatology. 124 (2): 360–366. PMID 15675955.
- Yamasaki K, Schauber J, Coda A, Lin H, Dorschner RA, Schechter NM, et al. (October 2006). "Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin". FASEB Journal. 20 (12): 2068–2080. S2CID 18170331.
- Debela M, Hess P, Magdolen V, Schechter NM, Steiner T, Huber R, et al. (October 2007). "Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7". Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16086–16091. PMID 17909180.
