KLK9
| KLK9 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 51 – 51.01 Mb | Chr 7: 43.44 – 43.45 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.[5]
Function
KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues.[6][7][8] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin.[5]
Clinical significance
KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian[9] and breast cancer patients.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000213022 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047884 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 10783266.
- ^ "Entrez Gene: KLK9".
- S2CID 436200.
- S2CID 83910246.
- PMID 11691797.
- S2CID 6515644.
Further reading
- Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Research. 61 (21): 7811–8. PMID 11691797.
- Yousef GM, Luo LY, Diamandis EP (1999). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Research. 19 (4B): 2843–52. PMID 10652563.
- Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. PMID 11054574.
External links
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