Kainate receptor

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Kainate receptors
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Kainic acid
Glutamic acid

Kainate receptors, or kainic acid receptors (KARs), are

GABA
through a presynaptic mechanism.

Structure

There are five types of kainate receptor subunits, GluR5 (GRIK1), GluR6 (GRIK2), GluR7 (GRIK3), KA1 (GRIK4) and KA2 (GRIK5), which are similar to AMPA and NMDA receptor subunits and can be arranged in different ways to form a tetramer, a four subunit receptor.[1] GluR5-7 can form homomers (ex. a receptor composed entirely of GluR5) and heteromers (ex. a receptor composed of both GluR5 and GluR6), however, KA1 and KA2 can only form functional receptors by combining with one of the GluR5-7 subunits.

Since 2009 the kainate receptor subunits have been renamed to correspond with their gene name. Hence GluR5-7 are now GluK1-3 and KA1 and KA2 are GluK4 and GluK5, respectively.[2]

Each KAR subunit begins with a 400-residue extracellular N-terminal domain, which plays a key role in assembly, followed by the first segment of the neurotransmitter-binding cleft, called S1. This segment then passes through the cell membrane, forming the first of three membrane-spanning regions, M1. The M2 segment then begins on the cytoplasmic face of the membrane, pushes into the cell membrane about half way, and then dips back out to the cytoplasm. This segment, termed the "p loop," determines the calcium permeability of the receptor. M2 turns into M3, another transmembrane segment which emerges on the extracellular face to complete the neurotransmitter binding site (a portion called S2). M4 begins extracellularly, and passes again through the membrane into the cytoplasm, forming the C-terminal of the protein.

Differences in the ligand binding pocket allow for the development of moderately subunit-selective kainate receptor agonists and antagonists.

Conductance

The ion channel formed by kainate receptors is permeable to sodium and potassium ions. The single channel conductance of kainate receptor channels is similar to that of AMPA channels, at about 20 pS. However, rise and decay times for postsynaptic potentials generated by KARs are slower than for AMPA postsynaptic potentials. Their permeability to Ca2+ is usually very slight but varies with subunits and RNA editing at the tip of the p loop.[3]

Known KAR Roles in Neurons

Heteromers

Many kainate receptors appear to exist as heteromers. The 'high-affinity' subunits GluK4 and GluK5 can only form functional channels as heteromers with 'low-affinity' subunits (GluK1-3).

Roles

Kainate receptors have both presynaptic and postsynaptic actions.

NMDA receptors, and their function is less well defined. The convulsant kainic acid induces seizures, in part, by activation of kainate receptors containing the GluK2 subunit and also probably via AMPA receptors[5]
Activation of kainate receptors containing the GluK1 subunit can also induce seizures but deletion of this subunit does not reduce seizure susceptibility to kainate or in other seizure models. Deletion of either GluK1 or GluK2 does not alter kindling epileptogenesis or the expression of kindled seizures.

Recent investigation through

development
.

One of the larger connections and roles that kainate receptors have been shown to have is to several neurological diseases and conditions. KAR expression and distribution has shown a linkage to

autism, Huntington's, bipolar disorder, and epilepsy among others. Most come through mutations of GluK1-5. The causation is unclear and the subject of further investigation.[7]

Plasticity

Unlike AMPA receptors, kainate receptors play only a minor role in signaling at synapses.[8] Kainate receptors have a subtle role in synaptic plasticity, affecting the likelihood that the postsynaptic cell will fire in response to future stimulation.[9][10] Activating kainate receptors in the presynaptic cell can affect the amount of neurotransmitters that are released[3][10][11] This effect may occur quickly and last for a long time,[11] and the effects of repetitive stimulation of KARs can be additive over time.[10]

Ligands

Agonists

Antagonists

See also

References

  1. PMID 10049997. Archived from the original
    (abstract) on 2009-02-13. Retrieved 2007-12-28.
  2. PMID 18655795
    .
  3. ^
    S2CID 5108956
    .
  4. ^
    PMID 21256604
    .
  5. PMID 24760837
    .
  6. PMID 24139035
    .
  7. PMID 21129167
    .
  8. S2CID 1993509
    .
  9. PMID 11069933
    .
  10. ^
    PMID 15721240
    .
  11. ^
    S2CID 24169827
    .

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Kainate_receptor&oldid=1211873520"