Katie Doores

Katherine Jane Doores is a British biochemist who is a senior lecturer in the School of Immunology & Microbial Sciences at King's College London. During the COVID-19 pandemic Doores studied the levels of antibodies in patients who had suffered from COVID-19.^[1]

Early life and education

Doores was born in the United Kingdom. In 2003, Doores received an MChem in chemistry from the University of Oxford. In 2008, Doores received a PhD in organic chemistry from the University of Oxford. Ben G. Davis was her advisor.^[2] In 2013, she completed post doctoral work in the Department of Immunology and Microbial Sciences at the Scripps Research Institute in La Jolla, California.^{[citation needed]}

Research and career

When Doores was a graduate student at Oxford, she studied

From 2013 to 2017, Doores was a lecturer in the Department of Infectious Diseases at King's College London. Doores was awarded a Medical Research Council fellowship to establish her own laboratory at King's College. She was made a European Molecular Biology Organization (EMBO) Young Investigator in 2017.^[7] In 2017, Doores became a senior lecturer in the Department of Infectious Diseases at King's College.^{[citation needed]}

Many disease-causing

During the COVID-19 pandemic Doores studied the levels of antibodies in patients who had suffered from COVID-19 in Guy's and St Thomas' NHS Foundation Trust.^[9][10] Her research showed that while 60% of COVID-19 patients elicited a strong antibody response, only 17% of them retained this potency three months later.^[1][11][12] In some cases, patients entirely lost their antibody response.^[1] These results implied that immunity to COVID-19 might be short lived, and that people may become reinfected during a second wave of infection.^[1]

Selected publications

Scholia has an author profile for Katie Doores.

• Doores, Katie J. (2007). Novel Methods for the Synthesis of Glycoimmunological Probes (PhD). University of Oxford. Mathematical and Physical Sciences Division.
  OCLC 232193273
  .
• Doores, K. J.; Bonomelli, C.; Harvey, D. J.; Vasiljevic, S.; Dwek, R. A.; Burton, D. R.; Crispin, M.; Scanlan, C. N. (19 July 2010). "Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens" (PDF). Proceedings of the National Academy of Sciences. 107 (31): 13800–13805.
  PMID 20643940. Wikidata
  ()
• Doores, Katie J.; Burton, Dennis R. (15 October 2010). "Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16". Journal of Virology. 84 (20): 10510–10521.
  PMID 20686044. Wikidata
  ()
• Pejchal, R.; Doores, K. J.; Walker, L. M.; Khayat, R.; Huang, P.-S.; Wang, S.-K.; Stanfield, R. L.; Julien, J.-P.; Ramos, A.; Crispin, M.; Depetris, R.; Katpally, U.; Marozsan, A.; Cupo, A.; Maloveste, S.; Liu, Y.; McBride, R.; Ito, Y.; Sanders, R. W.; Ogohara, C.; Paulson, J. C.; Feizi, T.; Scanlan, C. N.; Wong, C.-H.; Moore, J. P.; Olson, W. C.; Ward, A. B.; Poignard, P.; Schief, W. R.; Burton, D. R.; Wilson, I. A. (13 October 2011). "A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield". Science. 334 (6059): 1097–1103.
  PMID 21998254. Wikidata
  ()
• Walker, Laura M.; Huber, Michael; Doores, Katie J.; Falkowska, Emilia; Pejchal, Robert; Julien, Jean-Philippe; Wang, Sheng-Kai; Ramos, Alejandra; Chan-Hui, Po-Ying; Moyle, Matthew; Mitcham, Jennifer L.; Hammond, Phillip W.; Olsen, Ole A.; Phung, Pham; Fling, Steven; Wong, Chi-Huey; Phogat, Sanjay; Wrin, Terri; Simek, Melissa D.; Principal Investigators, Protocol G.; Koff, Wayne C.; Wilson, Ian A.; Burton, Dennis R.; Poignard, Pascal (22 September 2011). "Broad neutralization coverage of HIV by multiple highly potent antibodies". Nature. 477 (7365): 466–470.
  PMID 21849977. Wikidata
  ()
• Sok, D.; Doores, K. J.; Briney, B.; Le, K. M.; Saye-Francisco, K. L.; Ramos, A.; Kulp, D. W.; Julien, J.-P.; Menis, S.; Wickramasinghe, L.; Seaman, M. S.; Schief, W. R.; Wilson, I. A.; Poignard, P.; Burton, D. R. (14 May 2014). "Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV". Science Translational Medicine. 6 (236): 236ra63.
  PMID 24828077. Wikidata
  ()
• Seabright, Gemma E.; Doores, Katie J.; Burton, Dennis R.; Crispin, Max (May 2019). "Protein and Glycan Mimicry in HIV Vaccine Design". Journal of Molecular Biology. 431 (12): 2223–2247.
  PMID 31028779. Wikidata
  ()
• Avanzato, Victoria A.; Oguntuyo, Kasopefoluwa Y.; Escalera-Zamudio, Marina; Gutierrez, Bernardo; Golden, Michael; Kosakovsky Pond, Sergei L.; Pryce, Rhys; Walter, Thomas S.; Seow, Jeffrey; Doores, Katie J.; Pybus, Oliver G.; Munster, Vincent J.; Lee, Benhur; Bowden, Thomas A. (10 December 2019). "A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex" (PDF). Proceedings of the National Academy of Sciences. 116 (50): 25057–25067.
  PMID 31767754. Wikidata
  ()
• Seow, Jeffrey; Graham, Carl; Merrick, Blair; Acors, Sam; Steel, Kathryn J.A.; Hemmings, Oliver; O'Bryne, Aoife; Kouphou, Neophytos; Pickering, Suzanne; Galao, Rui; Betancor, Gilberto; Wilson, Harry D; Signell, Adrian W; Winstone, Helena; Kerridge, Claire; Temperton, Nigel; Snell, Luke; Bisnauthsing, Karen; Moore, Amelia; Green, Adrian; Martinez, Lauren; Stokes, Brielle; Honey, Johanna; Izquierdo-Barras, Alba; Arbane, Gill; Patel, Amita; OConnell, Lorcan; O Hara, Geraldine; MacMahon, Eithne; Douthwaite, Sam; Nebbia, Gaia; Batra, Rahul; Martinez-Nunez, Rocio; Edgeworth, Jonathan D.; Neil, Stuart J.D.; Malim, Michael H.; Doores, Katie (11 July 2020). "Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection".
  medRxiv 10.1101/2020.07.09.20148429v1
  .