Kava
Kava | |
---|---|
Piper methysticum leaves | |
Scientific classification | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Magnoliids |
Order: | Piperales |
Family: | Piperaceae |
Genus: | Piper |
Species: | P. methysticum
|
Binomial name | |
Piper methysticum |
Kava or kava kava (Piper methysticum:
The root of the plant is used to produce a drink with sedative, anesthetic, and euphoriant properties. Its active ingredients are called kavalactones.[8] A systematic review done by the British nonprofit Cochrane concluded it was likely to be more effective than placebo at treating short-term anxiety.[9]
Moderate consumption of kava in its traditional form, i.e., as a water-based suspension of kava roots, has been deemed to present an "acceptably low level of health risk" by the
History and names
Kava is conspecific with Piper wichmannii, indicating Kava was domesticated from Piper wichmannii (syn. Piper subbullatum).[13][14] Kava originated in either New Guinea or Vanuatu by seafarers.
It was spread by the
According to Lynch (2002), the reconstructed
In the
Characteristics
Kava was historically grown only in the Pacific islands of Hawaii, Federated States of Micronesia, Vanuatu, Fiji, the Samoas, and Tonga. An inventory of P. methysticum distribution showed it was cultivated on numerous islands of Micronesia, Melanesia, Polynesia, and Hawaii, whereas specimens of P. wichmannii were all from Papua New Guinea, the Solomon Islands, and Vanuatu.[22]
The kava shrub thrives in loose, well-drained soils where plenty of air reaches the roots. It grows naturally where rainfall is plentiful, attaining over 78 inches (2,000 mm) per year. Ideal growing conditions are 70–95 °F (21–35 °C) and 70–100% relative humidity. Too much sunlight is harmful, especially in early growth, because kava is an understory crop.[23]
Kava cannot reproduce sexually. Female flowers are especially rare and do not produce fruit even when hand-pollinated. Its cultivation is entirely by propagation from stem cuttings.[24]
Traditionally, plants are harvested around four years of age, as older plants have higher concentrations of kavalactones. After reaching about 2 metres (6.6 ft) in height, plants grow a wider stalk and additional stalks, but not much taller. The roots can reach a depth of 60 centimetres (2.0 ft).
Cultivars
Kava consists of sterile cultivars cloned from its wild ancestor, Piper wichmanii.[7] Today it comprises hundreds of different cultivars grown across the Pacific. Each cultivar has not only different requirements for successful cultivation, but also displays unique characteristics both in terms of its appearance and its psychoactive properties.[7]
Noble and non-noble kava
Scholars make a distinction between the so-called noble and non-noble kava. The latter category comprises the so-called tudei (or "two-day") kavas, medicinal kavas, and wild kava (Piper wichmanii, the ancestor of domesticated Piper methysticum).[7][25] Traditionally, only noble kavas have been used for regular consumption, due to their more favourable composition of kavalactones and other compounds that produce more pleasant effects and have lower potential for causing negative side effects, such as nausea, or "kava hangover".[7][11]
The perceived benefits of noble cultivars explain why only these cultivars were spread around the Pacific by Polynesian and Melanesian migrants, with presence of non-noble cultivars limited to the islands of Vanuatu, from which they originated.[7] More recently, it has been suggested that the widespread use of tudei cultivars in the manufacturing of several kava products might have been the key factor contributing to the rare reports of adverse reactions to kava observed among the consumers of kava-based products in Europe.[11]
Tudei varieties have traditionally not been grown in Hawaii and Fiji, but in recent years there have been reports of farmers attempting to grow "isa" or "palisi" non-noble cultivars in Hawaii, and of imports of dried tudei kava into Fiji for further re-exporting.[26] The tudei cultivars may be easier and cheaper to grow: while it takes up to 5 years for noble kava to mature, non-noble varieties can often be harvested just one year after being planted.
The concerns about the adverse effects of non-noble varieties, produced by their undesirable composition of kavalactones and high concentrations of potentially harmful compounds (flavokavains, which are not present in any significant concentration in the noble varieties), have led to legislation prohibiting exports from countries such as Vanuatu.[11] Likewise, efforts have been made to educate non-traditional customers about the difference between noble and non-noble varieties and that non-noble varieties do not offer the same results as noble cultivars.[27][28] In recent years, government regulatory bodies and non-profit NGOs have been set up with the declared aim of monitoring kava quality; producing regular reports; certifying vendors selling proper, noble kava; and warning customers against products that may contain tudei varieties.[29]
Growing regions
In Vanuatu, exportation of kava is strictly regulated. Only cultivars classified as noble are allowed to be exported. Only the most desirable cultivars for everyday drinking are classified as noble to maintain quality control. In addition, their laws mandate that exported kava must be at least five years old and farmed organically. Their most popular noble cultivars are "Borogu" or "Borongoru" from
In Hawaii, there are many other cultivars of kava (Hawaiian: ʻawa). Some of the most popular cultivars are Mahakea, Moʻi, Hiwa, and Nene. The Aliʻi (kings) of precolonial Hawaii coveted the Moʻi variety, which had a strong cerebral effect due to a predominant amount of the kavalactone kavain. This sacred variety was so important to them that no one but royalty could ever experience it, "lest they suffer an untimely death". The reverence for Hiwa in old Hawaiʻi is evident in this portion of a chant recorded by Nathaniel Bright Emerson and quoted by E. S. Craighill and Elizabeth Green Handy: "This refers to the cup of sacramental ʻawa brewed from the strong, black ʻawa root (ʻawa hiwa), which was drunk sacramentally by the kumu hula":
The day of revealing shall see what it sees:
A seeing of facts, a sifting of rumors,
An insight won by the black sacred 'awa,
A vision like that of a god![30]
Winter describes a hula prayer for inspiration that contains the line, He ʻike pū ʻawa hiwa. Pukui and Elbert translated this as "a knowledge from kava offerings". Winter explains that ʻawa, especially of the Hiwa variety, was offered to hula deities in return for knowledge and inspiration.[30]
Relationship with kawakawa
The Kawakawa (Piper excelsum) plant, known also as "Māori kava", may be confused with kava. While the two plants look similar and have similar names, they are different, but related, species. Kawakawa is a small tree endemic to New Zealand, having importance to traditional medicine and Māori culture. As noted by the Kava Society of New Zealand, "in all likelihood, the kava plant was known to the first settlers of Aotearoa [New Zealand]. It is also possible that (just like the Polynesian migrants that settled in Hawaii) the Maori explorers brought some kava with them. Unfortunately, most of New Zealand is simply too cold for growing kava and hence the Maori settlers lost their connection to the sacred plant."[31] Further, "in New Zealand, where the climate is too cold for kava, the Maori gave the name kawa-kawa to another Piperaceae M. excelsum, in memory of the kava plants they undoubtedly brought with them and unsuccessfully attempted to cultivate. The Maori word kawa also means "ceremonial protocol", recalling the stylized consumption of the drug typical of Polynesian societies".[7] Kawakawa is commonly used in Maori traditional medicine for the treatment of skin infections, wounds, and cuts, and (when prepared as a tea) for stomach upsets and other minor illnesses.[32]
Composition
Fresh kava root contains on average 80%
.In general, kavalactone content is greatest in the roots and decreases higher up the plant into the stems and leaves.
The mature roots of the kava plant are harvested after a minimum of four years (at least five years, ideally) for peak kavalactone content. Most kava plants produce around 50 kg (110 lb) of root when they are harvested. Kava root is classified into two categories: crown root (or chips) and lateral root. Crown roots are the large-diameter pieces that look like 1.5 to 5 inches (38 to 127 mm)-diameter wooden poker chips. Most kava plants consist of approximately 80% crown root upon harvesting. Lateral roots are smaller-diameter roots that look more like a typical root. A mature kava plant is about 20% lateral roots. Kava lateral roots have the highest content of kavalactones in the kava plant. "Waka" grade kava is made of lateral roots only.
Pharmacology
Constituents
A total of 18 different kavalactones (or kavapyrones) have been identified to date, at least 15 of which are active.[33] However, six of them, including kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin, have been determined to be responsible for about 96% of the plant's pharmacological activity.[33] Some minor constituents, including three chalcones — flavokavain A, flavokavain B, and flavokavain C — have also been identified,[33] as well as a toxic alkaloid (not present in the consumable parts of the plant[34]), pipermethystine.[35] Alkaloids are present in the roots and leaves.[36]
Pharmacodynamics
The following pharmacological actions have been reported for kava and/or its major active constituents:[37]
- Potentiation of GABAA receptor activity (by kavain, dihydrokavain, methysticin, dihydromethysticin, and yangonin).
- Inhibition of the reuptake of norepinephrine (by kavain and methysticin) and possibly also of dopamine (by kavain and desmethoxyyangonin).
- Binding to the CB1 receptor (by yangonin).[38]
- Inhibition of voltage-gated sodium channels and voltage-gated calcium channels (by kavain and methysticin).
- Monoamine oxidase B reversible inhibition (by all six of the major kavalactones).
Receptor binding assays with botanical extracts have revealed direct interactions of leaf extracts of kava (which appear to be more active than root extracts) with the
Potentiation of GABAA receptor activity may underlie the
Heavy, long-term use of kava has been found to be free of association with reduced ability in saccade and cognitive tests, but has been associated with elevated liver enzymes.[43]
Detection
Recent usage of kava has been documented in forensic investigations by quantitation of kavain in blood specimens. The principal urinary metabolite, conjugated 4'-OH-kavain, is generally detectable for up to 48 hours.[44]
Preparations
Traditional preparation
Kava is consumed in various ways throughout the
The extract is an emulsion of kavalactone droplets in starch and buttermilk. The taste is slightly pungent, while the distinctive aroma depends on whether it was prepared from dry or fresh plant, and on the variety. The colour is grey to tan to opaque greenish.
Kava prepared as described above is much more potent than processed kava. Chewing produces the strongest effect because it produces the finest particles. Fresh, undried kava produces a stronger beverage than dry kava. The strength also depends on the species and techniques of cultivation.
In Vanuatu, a strong kava drink is normally followed by a hot meal or tea. The meal traditionally follows some time after the drink so that the
In Papua New Guinea, the locals in Madang province refer to their kava as waild koniak ("wild cognac" in English).
Fijians commonly share a drink called grog, made by pounding sun-dried kava root into a fine powder, straining and mixing it with cold water. Traditionally, grog is drunk from the shorn half-shell of a coconut, called a bilo. Grog is very popular in Fiji, especially among young men, and often brings people together for storytelling and socializing. Drinking grog for a few hours brings a numbing and relaxing effect to the drinker; grog also numbs the tongue, and grog drinking typically is followed by a "chaser" or sweet or spicy snack to follow a bilo.
Supplements and pharmaceutical preparations
Water extraction is the traditional method for preparation of the plant.
Concerns
Numerous scholars[47] and regulatory bodies[48][49] have raised concerns over the safety profile of such products.
One group of scholars say that organic solvents introduce compounds that may affect the liver into the standardized product; these compounds are not extracted by water and are consequently largely absent from kava prepared with water.[50] For instance, when compared with water extraction, organic solvents extract vastly larger amounts of flavokavains, compounds associated with adverse reactions to kava that are present in very low concentrations in noble kava, but significant in non-noble.[51][11]
Also, "chemical solvents used do not extract the same compounds as the natural water extracts in traditional use. The extraction process may exclude important modifying constituents soluble only in water".[50] In particular, it has been noted that, unlike traditional water-based preparations, products obtained with the use of organic solvents do not contain glutathione, an important liver-protecting compound.[52] Another group of researchers noted: "The extraction process (aqueous vs. acetone in the two types of preparations) is responsible for the difference in toxicity as extraction of glutathione in addition to the kava lactones is important to provide protection against hepatotoxicity".[52]
It has also been argued that kavalactone extracts have often been made from low-quality plant material, including the toxic aerial parts of the plant, non-noble kava varieties, or plants affected by mold — which, in light of the chemical solvents' ability to extract far greater amounts of the potentially toxic compounds than water, makes them particularly problematic.
In the context of these concerns, the World Health Organization advises against the consumption of ethanolic and acetonic kavalactone extracts, and says that "products should be developed from water-based suspensions of kava".[49] The government of Australia prohibits the sales of such kavalactone extracts, and only permits the sale of kava products in their natural form or produced with cold water.[53]
Kava culture
Kava is used for medicinal, religious, political, cultural, and social purposes throughout the Pacific. These cultures have a great respect for the plant and place a high importance on it. In Fiji, for example, a formal yaqona (kava) ceremony will often accompany important social, political, or religious functions, usually involving a ritual presentation of the bundled roots as a sevusevu (gift) and drinking of the yaqona itself.[54][55] Due to the importance of kava in religious rituals and the seemingly (from the Western point of view) unhygienic preparation method, its consumption was discouraged or even banned by Christian missionaries.[7]
Kava bars
With kava's increasing popularity, bars serving the plant in its liquid state are beginning to open up outside of the South Pacific.[11][56]
A 2010 review concluded that it's possible that ethanol combined with kava may be the cause of kava hepatotoxicity.[57] While some bars have been committed to only serving the traditional forms and types of kava, other establishments have been accused of serving non-traditionally consumed non-noble kava varieties, which are cheaper but far more likely to cause unpleasant effects and adverse reactions, or of serving kava with other substances, including alcohol.[58]
Effects of consumption
The nature of effects will largely depend on the cultivar of the kava plant and the form of its consumption.[59] Traditionally, only noble kava cultivars have been consumed, as they are accepted as safe and produce desired effects.[60] The specific effects of various noble kavas depend on various factors, such as the cultivar used (and the related specific composition of kavalactones), age of the plant, and method of consumption.[59] However, it can be stated that in general, noble kava produces a state of calmness, relaxation, and well-being without diminishing cognitive performance.[7][61][62] Kava may produce an initial talkative period, followed by muscle relaxation and eventual sleepiness.[63]
As noted in one of the earliest Western publications on kava (1886): "A well prepared Kava potion drunk in small quantities produces only pleasant changes in behavior. It is therefore a slightly stimulating drink which helps relieve great fatigue. It relaxes the body after strenuous efforts, clarifies the mind and sharpens the mental faculties".[64]
Despite its psychoactive effects, kava is not considered to be physically addictive and its use does not lead to dependency.[65][66]
Adverse drug interactions
Kava taken in combination with alprazolam can cause a semicomatose state in humans.[67]
Research
A 2010 review concluded that it's possible that ethanol combined with kava may be the cause of kava hepatotoxicity.[57]
Toxicity, safety, and potential side effects
General observations
There is limited safety information available on the effects of kava consumption, but in general, moderate consumption appears unlikely to be harmful, while there is evidence of harm from heavy use.[10]
Effects on the liver
There is published evidence of the
Other adverse reactions
Adverse reactions may result from the poor quality of kava raw material used in the manufacturing of various kava products.[29][36][69][47] In addition to the potential for hepatotoxicity, adverse reactions from chronic use may include visual impairment, rashes or dermatitis, seizures, weight loss, and malnutrition, but there is only limited high-quality research on these possible effects.[10][36]
On the basis of research findings and long history of safe use across the South Pacific, experts recommend using water-based extractions of high-quality peeled rhizome and roots of the noble kava cultivars to minimize the potential of adverse reactions to chronic use.[10][29]
Potential interactions
Several adverse interactions with drugs have been documented, both prescription and nonprescription — including, but not limited to,
A few notable potential drug interactions are, but are not limited to:
- Alcohol: It has been reported that combined use of alcohol and kava extract can have additive sedative effects.[36][70] Regarding cognitive function, kava has been shown to have additive cognitive impairments while taken with alcohol when compared to taking placebo and alcohol alone.[71]
- Anxiolytics (CNS depressants such as benzodiazepines and barbiturates): Kava may have potential additive CNS depressant effects (such as sedation and anxiolytic effects) with
- levodopa: One of levodopa's chronic side effects that Parkinson's patients experience is the "on-off phenomenon" of motor fluctuations, where there will be periods of oscillations between "on", where the patient experiences symptomatic relief, and "off", where the therapeutic effect wears off early.[72] When taking levodopa and kava together, it has been shown that there is an increased frequency of this "on-off phenomenon".[73]
- As a monoamine oxidase inhibitor, there is a potential risk of hypertensive crisis when consuming tyramine-containing foods; risk would be increased if taken in combination with other monoamine oxidase inhibitors.
Kava dermopathy
Long-term and heavy kava consumption is associated with a reversible
Research
Kava is under preliminary research for its potential
Traditional medicine
Over centuries, kava has been used in the
Regulation
Kava remains legal in most countries. Regulations often treat it as a food or dietary supplement.
Australia
In Australia, the supply of kava is regulated through the National Code of Kava Management.[81] Travellers to Australia are allowed to bring up to 4 kg of kava in their baggage, provided they are at least 18 years old and the kava is in root or dried form. Commercial import of larger quantities is allowed, under licence for medical or scientific purposes. These restrictions were introduced in 2007 after concern about abuse of kava in indigenous communities. Initially, the import limit was 2 kg per person; it was raised to 4 kg in December 2019, and a pilot program allowing for commercial importation was implemented on 1 December 2021.[82][83]
The Australian Therapeutic Goods Administration has recommended no more than 250 mg of kavalactones be taken in a 24‑hour period.[84]
Kava possession is limited to 2 kg per adult in the Northern Territory.[85][86] While it was previously banned in Western Australia in the 2000s, the Western Australian Health Department announced the lifting of the ban in February 2017, bringing Western Australia "into line with other States" where it has always remained legal, albeit closely regulated.[87]
Europe
Following discussions on the safety of certain pharmaceutical products derived from kava and sold in Germany, the EU imposed a temporary ban on imports of kava-based pharmaceutical products in 2002. The sale of kava plant became regulated in
In the United Kingdom, it is a criminal offence to sell, supply, or import any medicinal product containing kava for human consumption.[93] It is legal to possess kava for personal use or to import it for purposes other than human consumption (e.g., for animals).
Until August 2018, Poland was the only EU country with an "outright ban on kava" and where the mere possession of kava was prohibited and may have resulted in a prison sentence.[94] Under the new legislation, kava is no longer listed among prohibited substances and it is therefore legal to possess, import, and consume the plant,[95] but it remains illegal to sell it within Poland for the purpose of human consumption.[96]
In the Netherlands, for unknown reasons, the ban was never lifted, and it is still prohibited to prepare, manufacture, or trade kava or goods containing kava.[97]
New Zealand
When used traditionally, kava is regulated as a food under the Food Standards Code. Kava may also be used as an herbal remedy, where it is currently regulated by the Dietary Supplements Regulations. Only traditionally consumed forms and parts of the kava plant (i.e., pure roots of the kava plant, water extractions prepared from these roots) can legally be sold as food or dietary supplements in New Zealand. The aerial parts of the plant (growing up and out of the ground), unlike the roots, contain relatively small amounts of kavalactones; instead, they contain a mildly toxic alkaloid, pipermethysticine.[48] While not normally consumed, the sale of aerial plant sections and non-water based extract (such as CO2, acetonic, or ethanol extractions) is prohibited for the purpose of human consumption (but can be sold as an ingredient in cosmetics or other products not intended for human consumption).[98][99]
North America
In 2002, Health Canada issued an order prohibiting the sale of any product containing kava.[100] While the restrictions on kava were lifted in 2012,[101] Health Canada lists five kava ingredients as of 2017.[102][103]
In 2002, the U.S. Food and Drug Administration issued a Consumer Advisory: "Kava-Containing Dietary Supplements May be Associated with Severe Liver Injury". No legal action was taken, and this advisory has since been archived.[104]
Vanuatu
The Pacific island-state of Vanuatu has passed legislation to regulate the quality of its kava exports. Vanuatu prohibits the export or consumption of non-noble kava varieties or the parts of the plant that are unsuitable for consumption (such as leaves and stems).[105]
See also
- List of herbs with known adverse effects
- Alcohol and Drugs History Society
- Betel
- Domesticated plants and animals of Austronesia
- Kava culture
- Nakamal
- Paan
- Samoa 'ava ceremony
- Samoan plant names
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- ^ "Kava". HealthLink BC, Government of British Columbia. 23 September 2021. Retrieved 3 March 2022.
- ^ "Ingredients - Kava". Health Canada. 2017. Retrieved 1 July 2017.
- ^ "Consumer Advisory: Kava-Containing Dietary Supplements May be Associated with Severe Liver Injury". US Food and Drug Administration. 25 March 2002. Archived from the original on 3 June 2009. Retrieved 28 June 2020.
- ^ "Vanuatu - Legislation - Kava Act 2002". faolex.fao.org. Retrieved 2 July 2016.
External links
- "UNODC - Bulletin on Narcotics: The narcotic pepper - The chemistry and pharmacology of Piper methysticum and related species". United Nations Office on Drugs and Crime. 1973. pp. Issue 2. Retrieved 19 February 2014.
- Kava ban documents
- Piper methysticum information from the Hawaiian Ecosystems at Risk project (HEAR)
- Encyclopædia Britannica. Vol. 14 (9th ed.). 1882. .