Kimishige Ishizaka

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Kimishige Ishizaka
石坂 公成
La Jolla Institute for Allergy and Immunology
Notable studentsTadamitsu Kishimoto

Kimishige "Kimi" Ishizaka (石坂 公成, Ishizaka Kimishige, 3 December 1925 – 6 July 2018) was a Japanese

Gairdner Foundation International Award and the 2000 Japan Prize for his work in immunology.[3][4]

Early life and education

Ishizaka was born in Tokyo to Koki and Kiku Ishizaka. His father was a career soldier who retired in 1933 as a lieutenant general. Ishizaka obtained his medical qualifications and

PhD in 1948 from the University of Tokyo. He "was captivated by immunology while taking a summer course in college" and abandoned plans to become a physician.[5]

Career

From 1953 to 1962, he headed the immunoserology division at the department of serology at the Japanese National Institute of Health. During his tenure in that position he spent two years as a research fellow at Caltech (1957–1959).[6][7]

In 1962, Ishizaka and his wife

University of Colorado Medical School, as well as chief of immunology of its associated Children's Asthma Research Institute[6] and CARIH.[9] In 1965, he was promoted to associate professor at University of Colorado Denver.[6]

While at Denver, the Ishizakas discovered the antibody class Immunoglobulin E (IgE) in 1966–1967[10][11] and its interplay with mast cells.[3] They demonstrated the IgE's critical role in mediating the release of histamine from mast cells.[2] The discovery of IgE is considered a milestone in immunology and the understanding of allergy.[2][3]

In 1970, Ishizaka was appointed as O'Neill Professor of Medicine and Microbiology at

La Jolla Institute for Allergy and Immunology in La Jolla, California.[13]

After retiring in 1996,[14] he returned to Japan and served as honorary director of the Institute of Immunology at Yamagata University.[15]

Recognition

The Ishizakas received numerous awards for their work in allergy and immunology. In 1972, they received the

Gairdner Foundation International Award.[16] In 1974, he received the Asahi Cultural Award, the Imperial Prize of the Japan Academy, and the Japanese Order of Culture.[6][15] In 1979, they received the Borden Award.[16] In 2000, he was awarded the 16th Japan Prize.[3][15]

Personal life and death

Ishizaka was married to

Yamagata, Yamagata.[15]

References

  1. PMID 4162440
    .
  2. ^
    ISBN 978-0-12-811329-5
    .
  3. ^ a b c d "Laureates of the Japan Prize: Dr Kimishige Ishizaka –Award Citation". The Japan Prize Foundation. 2000. Retrieved 12 November 2007.
  4. ^ "Japan Prize laureates announced". BBC News. 17 December 1999. Retrieved 12 November 2007.
  5. ISSN 0362-4331
    . Retrieved 19 July 2019.
  6. ^ a b c d e f g "Laureates of the Japan Prize: Dr. Kimishige Ishizaka". The Japan Prize Foundation. 2000. Retrieved 8 July 2018.
  7. ^
    PMID 24925421
    – via S. Karger AG.
  8. ^ Cohen, Sheldon (March 2005). "The Ishizakas and the search for reaginic antibodies". The Journal of Allergy and Clinical Immunology.
  9. ^ Anderson, Andrea (1 June 2017). "Self-Experimentation Led to the Discovery of IgE". The Scientist Magazine. Retrieved 8 July 2018.
  10. ISBN 978-3-662-11196-3
    .
  11. ISBN 978-0-313-35274-4
    .
  12. ^ "Kimishige Ishizaka". National Academy of Sciences. Retrieved 8 July 2018.
  13. ^ Kimishige Ishizaka. "About the founding director". La Jolla Institute for Allergy and Immunology.
  14. S2CID 24171482
    .
  15. ^ a b c d "石坂公成さんが死去 アレルギー発症の仕組み解明：朝日新聞デジタル". Asahi News (in Japanese). 6 July 2018. Retrieved 7 July 2018.
  16. ^ a b c d Sri Kantha, Sachi; Yamamoto, Saori (1 August 2015). "Trend-setting women scientists of biomedical research in Japan". International Medical Journal. 22: 224–226.

External links

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