Koch Institute for Integrative Cancer Research

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Coordinates: 42°21′44″N 71°5′19″W / 42.36222°N 71.08861°W / 42.36222; -71.08861
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This article is about the MIT cancer research center. For the German disease control and prevention institution, see Robert Koch Institute.
Koch Institute for Integrative Cancer Research at MIT
Logo of the MIT Koch Institute
EstablishedOctober 9, 2007
Research typeBasic (non-clinical) research
Budget$93.2 million[1]
Field of research
Cancer research
DirectorMatthew Vander Heiden
Faculty29[2]
Staff500[2]
Address77 Massachusetts Ave.
Building 76
LocationCambridge, Massachusetts
Campus180,000 square feet (17,000 m2)
AffiliationsNational Cancer Institute
Operating agency
Massachusetts Institute of Technology
Websiteki.mit.edu
View of a seven story building seen from a grassy courtyard
Koch Institute for Integrative Cancer Research

The Koch Institute for Integrative Cancer Research at MIT (/koʊk/ KOHK; also referred to as the Koch Institute or KI) is a cancer research center affiliated with the Massachusetts Institute of Technology (MIT) located in Cambridge, Massachusetts, United States. The institute is one of seven National Cancer Institute-designated basic laboratory cancer centers in the United States.[3]

The institute was launched in October 2007 with a $100 million grant from

David H. Koch and the 180,000 square feet (17,000 m2) research facility opened in December 2010, replacing the MIT Center for Cancer Research (CCR).[4][5] The institute is affiliated with 29 MIT faculty members in both the Schools of Engineering and Science.[6]

History

In 1974, the Center for Cancer Research was founded by 1969

Phillip Sharp (1993), and H. Robert Horvitz (2002).[9]

In 2006, President

Koch Biology Building.[11] The gift supported the construction of the estimated $240–$280 million facility, on the condition that MIT build the center even if fund raising fell short.[5]

Mission

The Koch Institute emphasizes basic research into how cancer is caused, progresses, and responds to treatment. Unlike many other NCI Cancer Centers, it will not provide medical care or conduct clinical research, but it partners with oncology centers such as the Dana-Farber Cancer Institute and Massachusetts General Hospital's Cancer Center.[12] The institute combines the existing faculty of the CCR with an equivalent number of engineering faculty to promote interdisciplinary approaches to diagnosing, monitoring, and treating cancer.[1]

The Koch Institute has identified five areas of research that it believes are critical for controlling cancer: Developing nanotechnology-based cancer therapeutics, creating novel devices for cancer detection and monitoring, exploring the molecular and cellular basis of metastasis, advancing personalized medicine through analysis of cancer pathways and drug resistance, engineering the immune system to fight cancer.[13]

Affiliates

The Koch Institute is home to faculty members from various departments, including Biology, Chemistry, Mechanical Engineering, and Biological Engineering; more than 40 laboratories and 500 researchers across the campus.

MacArthur Foundation Fellowship recipient.[14]

Notable faculty members affiliated with the Koch Institute include:[2]

Building

See also: Campus of the Massachusetts Institute of Technology

The 180,000 square feet (17,000 m2) research facility is located on the corner of Main Street and Ames Street near Kendall Square in Cambridge, Massachusetts. The building is located opposite the Whitehead Institute and Broad Institute and near the biology and chemical engineering buildings on the north-eastern end of MIT's campus. MIT broke ground on Building 76 in March 2008,[6] a topping-off ceremony was held in February 2009,[15] and the building was dedicated on March 4, 2011.[16]

The building was designed by Cambridge-based architecture firm Ellenzweig, which designed several other buildings on the MIT campus.

proteomics and flow cytometry, large-scale cell and animal facilities for genetic engineering and testing, advanced imaging equipment, and nanomaterials characterization labs.[6]

Activity since 2007

The KI remains funded by a NCI center grant as well as 110 fully funded projects. Research volume in 2017–2018 totaled $93.2 million.[1] As of 2009, notable grants include Mouse Models of Cancer Consortium, Integrative Cancer Biology Program, and the Centers for Excellence in Nanotechnology and Cancer.[12]

In 2011, scientists at the institute pinpointed a genetic change that makes lung cancer more likely to spread around the body and may help scientists develop new drugs to fight secondary tumors.[18]

In 2020, Alex K. Shalek, Christopher Love, Travis Hughes and Marc Wadsworth developed an updated protocol for the commonly used low-input RNA sequencing method Seq-Well, increasing output resolution by ten times.[19]

References

  1. ^ a b c d e "Annual Reports to the President, 2017–2018: Koch Institute for Integrative Cancer Research". Office of the President, Massachusetts Institute of Technology. Retrieved 2023-06-26.
  2. ^ a b c "People". The Koch Institute, Massachusetts Institute of Technology. Retrieved 2009-09-09.
  3. ^ "David H. Koch Institute for Integrative Cancer Research at MIT". National Cancer Institute. Retrieved 2023-06-03.
  4. ^ Trafton, Anne (October 9, 2007). "David H. Koch gives $100 million to MIT for cancer research". MIT News Office.
  5. ^ a b Strout, Erin (October 10, 2007). "MIT Receives $100-Million Gift for Cancer-Research Center". The Chronicle of Higher Education.
  6. ^ a b c Trafton, Anne (March 8, 2008). "MIT breaks ground for Koch institute". MIT News Office.
  7. ^ "Annual Reports to the President, 1994–1995: Center for Cancer Research". Office of the President, Massachusetts Institute of Technology. Retrieved 2009-08-08.
  8. ^ a b "Annual Reports to the President, 2006–2007: Center for Cancer Research" (PDF). Office of the President, Massachusetts Institute of Technology. Retrieved 2009-08-08.
  9. ^ a b Thomson, Elizabeth (June 26, 2006). "Cancer Center highlights past, present research". MIT News Office.
  10. ^ Richards, Patti (November 14, 2006). "MIT receives major grant from the Ludwig Fund to tackle metastasis". MIT News Office.
  11. ^ "Lecture marks Koch Building naming cancer-research gift". MIT News Office. September 29, 1999.
  12. ^ a b "The Koch Institute - Frequently Asked Questions". The Koch Institute, Massachusetts Institute of Technology. Retrieved 2009-09-08.
  13. ^ "Research". The David H. Koch Institute for Integrative Cancer Research at MIT. Retrieved 20 April 2011.
  14. ^ "The Koch Institute: Intramural Faculty". ki.mit.edu. Retrieved 2017-05-11.
  15. ^ "Highlights of Koch Institute Topping-Off Ceremony (video)". MIT News Office. February 20, 2009.
  16. ^ "While you were out". MIT News Office. September 2, 2009. Archived from the original on September 6, 2009.
  17. ^ Brobbey, Valery (February 26, 2008). "Cancer Building Groundbreaking Scheduled". The Tech.
  18. ^ Briggs, Helen (April 7, 2011). "Gene clue to how cancer spreads". BBC. Retrieved 21 April 2011.
  19. ^ "Technique to recover lost single-cell RNA-sequencing information: Boosting the efficiency of single-cell RNA-sequencing helps reveal subtle differences between healthy and dysfunctional cells". ScienceDaily. Retrieved 2021-02-17.

External links

42°21′44″N 71°5′19″W / 42.36222°N 71.08861°W / 42.36222; -71.08861

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