Kolbe–Schmitt reaction
(Redirected from
Kolbe-Schmitt reaction
)
Kolbe–Schmitt reaction | |
---|---|
Named after | |
Reaction type | Addition reaction |
Identifiers | |
Organic Chemistry Portal | kolbe-schmitt-reaction |
RSC ontology ID | RXNO:0000182 |
The Kolbe–Schmitt reaction or Kolbe process (named after
By using
biocides
used e.g. in personal care products.
The methodology is also used in the industrial synthesis of 3-hydroxy-2-naphthoic acid; the regiochemistry of the carboxylation in this case is sensitive to temperature.[6]
Reaction mechanism
The Kolbe–Schmitt reaction proceeds via the
phenoxide, classically sodium phenoxide (NaOC6H5), to carbon dioxide
to give the salicylate.
The final step is the reaction (anion with an acid
to form the desired salicylic acids (ortho- and para- isomers).
References
- .
- .
- .
- . (Review)
- ISBN 0-205-05838-8.
- ISBN 3-527-30673-0..
External links
- [1] Archived 18 October 2020 at the Wayback Machine English Translation of Kolbe's seminal 1860 German article in Annalen der Chemie und Pharmacie that describes the discovery of this reaction. English title: 'On the syntheses of salicylic acid'; German title "Ueber Synthese der Salicylsäure".
- [2] An animation of the reaction mechanism.