Kowalski ester homologation
The Kowalski ester homologation is a chemical reaction for the homologation of esters.[1][2]
This reaction was designed as a safer alternative to the
Arndt–Eistert synthesis, avoiding the need for diazomethane. The Kowalski reaction is named after its inventor, Conrad J. Kowalski
.
Reaction mechanism
The mechanism is disputed.[further explanation needed]
Variations
By changing the
ynol ethers.[citation needed
]
See also
References
- .
- ^ Reddy, R. E.; Kowalski, C. J. (1993). "Ethyl 1-naphthylacetate: ester homologation via ynolate anions". Organic Syntheses. 71: 146; Collected Volumes, vol. 9, p. 426.