LAMP3
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Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene.[5][6] It is one of the lysosome-associated membrane glycoproteins.
LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with
Studies have linked LAMP3 with the inhibition of the viral replication of Influenza A cells.[11]
Structure and Tissue Distribution
LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes.[9] LAMP3 has been shown to be highly expressed in dendritic cells during cell differentiation and maturation.[7] During human fetal development, between weeks 10 and 20, LAMP3 is highly expressed in the lungs, while in normal adult tissue cells LAMP3 is expressed in the lungs, appendix, testis and lymph nodes.[12]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000078081 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041247 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9721848.
- ^ "Entrez Gene: LAMP3 lysosomal-associated membrane protein 3".
- ^ PMID 27697285.
- ^ "ThermoFisher".
- ^ a b "CD208 (DC-LAMP)". BeckmanCoulter.
- PMID 14982840.
- PMID 21810281.
- ^ "LAMP3 lysosomal associated membrane protein 3 [ Homo sapiens (human) ]".
Further reading
- de Saint-Vis B, Vincent J, Vandenabeele S, et al. (1998). "A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment". Immunity. 9 (3): 325–36. PMID 9768752.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Akasaki K, Nakamura N, Tsukui N, et al. (2004). "Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes". Arch. Biochem. Biophys. 425 (2): 147–57. PMID 15111122.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Kanao H, Enomoto T, Kimura T, et al. (2005). "Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer". Cancer Res. 65 (19): 8640–5. PMID 16204031.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMID 16344560.
- Elliott B, Scolyer RA, Suciu S, et al. (2007). "Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma". Clin. Cancer Res. 13 (13): 3825–30. PMID 17606713.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9UQV4 (Human Lysosome-associated membrane glycoprotein 3 (LAMP3)) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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