LHX3
LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.[5][6][7]
Function
LHX3 encodes a protein of a large protein family, members of which carry the
pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]
Clinical significance
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.[7]
Interactions
LHX3 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000107187 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026934 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10598593.
- PMID 10717474.
- ^ a b c "Entrez Gene: LHX3 LIM homeobox 3".
- PMID 9452425.
Further reading
- Zhadanov AB, Bertuzzi S, Taira M, Dawid IB, Westphal H (1995). "Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues". Dev. Dyn. 202 (4): 354–64. S2CID 36677316.
- Zhadanov AB, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H (1995). "Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3". Genomics. 27 (1): 27–32. PMID 7665181.
- Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. PMID 9452425.
- Bach I, Rodriguez-Esteban C, Carrière C, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. S2CID 22326394.
- Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–67. PMID 10593900.
- Howard PW, Maurer RA (2000). "Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors". J. Biol. Chem. 275 (18): 13336–42. PMID 10788441.
- Parker GE, Sandoval RM, Feister HA, Bidwell JP, Rhodes SJ (2000). "The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix". J. Biol. Chem. 275 (31): 23891–8. PMID 10818088.
- Netchine I, Sobrier ML, Krude H, Krude H, Schnabel D, Maghnie M, Marcos E, Duriez B, Cacheux V (2000). "Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency". Nat. Genet. 25 (2): 182–6. S2CID 12358307.
- Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ (2000). "Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene". Biochem. Biophys. Res. Commun. 274 (1): 49–56. PMID 10903894.
- Sloop KW, Dwyer CJ, Rhodes SJ (2001). "An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form". J. Biol. Chem. 276 (39): 36311–9. PMID 11470784.
- Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. S2CID 4426785.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo". Development. 130 (9): 1915–25. S2CID 6211268.
- Kim SS, Kim Y, Shin YL, Kim GH, Kim TU, Yoo HW (2004). "Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging". Horm. Res. 60 (6): 277–83. S2CID 31256955.
- Dattani MT (2004). "Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene". J. Pediatr. Endocrinol. Metab. 16 (9): 1207–9. S2CID 45542882.
- West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Colvin SC, Sloop KW, Rhodes SJ (2004). "Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor". Endocrinology. 145 (11): 4866–79. PMID 15271874.
- Parker GE, West BE, Witzmann FA, Rhodes SJ (2005). "Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor". J. Cell. Biochem. 94 (1): 67–80. S2CID 41303062.
- Sobrier ML, Attié-Bitach T, Netchine I, Encha-Razavi F, Vekemans M, Amselem S (2006). "Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development". Gene Expr. Patterns. 5 (2): 279–84. PMID 15567726.
External links
- LHX3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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