LILRA4

LILRA4
Identifiers
Gene ontology
Molecular function	protein binding; signaling receptor binding; coreceptor activity;
Cellular component	membrane; integral component of membrane; integral component of plasma membrane; Fc-epsilon receptor I complex; plasma membrane;
Biological process	immune system process; negative regulation of interferon-alpha production; negative regulation of tumor necrosis factor production; negative regulation of toll-like receptor 7 signaling pathway; negative regulation of toll-like receptor 9 signaling pathway; Fc-epsilon receptor signaling pathway; innate immune response;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000277092 ENSG00000276798 ENSG00000274185 ENSG00000239961


n/a

UniProt


P59901


n/a

RefSeq (mRNA)


NM_012276


n/a

RefSeq (protein)


NP_036408


n/a

Location (UCSC)

Chr 19: 54.33 – 54.34 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.^[3]^[4]

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a

leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.^[4]

References

^ ^a ^b ^c ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
S2CID 20719684
.

^ ^a ^b "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

Further reading

Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64.
PMID 18048391
.

Sellick GS, Wade R, Richards S, et al. (2008). "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood. 111 (3): 1625–33.
PMID 18006695
.

Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89.
PMID 16777052
.

Cao W, Rosen DB, Ito T, et al. (2006). "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405.
PMID 16735691
.

Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene. 331: 159–64.
PMID 15094202
.

Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9.
PMID 12529506
.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
PMID 12477932
.

Rissoan MC, Duhen T, Bridon JM, et al. (2002). "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood. 100 (9): 3295–303.
PMID 12384430
.

Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8.
S2CID 2819935
.

Retrieved from "https://en.wikipedia.org/w/index.php?title=LILRA4&oldid=1188046705"

[refGRCh38Ensembl-1] ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10941842-3] S2CID 20719684
.

[entrez-4] "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

[2]

[3]

[4]