LIN28
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Location (UCSC) | Chr 1: 26.41 – 26.43 Mb | Chr 4: 133.73 – 133.75 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene.[5][6]
LIN28 encodes an
Function
Stem cell expression
LIN28 is thought to regulate the self-renewal of
LIN28 is highly expressed in human embryonic stem cells[14] and can enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts.[15]
Puberty
LIN28 overexpression in mice can cause gigantism and a delay in puberty onset, consistent with human genome-wide association studies suggesting that polymorphisms in the human LIN28B gene are associated with human height and puberty timing.[16] Mutations in LIN28B are associated with precocious puberty.[17]
LIN28 can regulate glucose homeostasis in mammals by increasing
Tissue regeneration
Mice genetically altered to produce LIN28 during their lifespan showed improved
Structure
Models of Lin28/let-7 complexes obtained through X-ray crystallography and NMR reveal that two folded domains of Lin28 recognize two distinct RNA regions.[21][22] The domains are sufficient for inhibition of let-7 in vivo.[10][23]
Applications
LIN28 is a marker of undifferentiated human embryonic stem cells[14] and has been used to enhance the efficiency of the formation of iPS cells from human fibroblasts.[15]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131914 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050966 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 12798299.
- ^ "Entrez Gene: LIN28 lin-28 homolog (C. elegans)".
- PMID 26199409.
- PMID 17473174.
- PMID 18292307.
- ^ S2CID 28899778.
- S2CID 23979766.
- S2CID 13248841.
- PMID 14643679.
- ^ PMID 14688391.
- ^ S2CID 86129154.
- PMID 20512147.
- PMID 23133486.
- PMID 21962509.
- ^ PMID 24209617.
- Fine D (November 7, 2013). "New Limb Regeneration Insight Surprises Scientists". Scientific American.
- PMID 23561442.
- PMID 22078496.
- S2CID 2201304.
- PMID 22078496.
Further reading
- Richards M, Tan SP, Tan JH, Chan WK, Bongso A (2004). "The transcriptome profile of human embryonic stem cells as defined by SAGE". Stem Cells. 22 (1): 51–64. PMID 14688391.
- Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V (2004). "Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation". Genome Biology. 5 (3): R13. PMID 15003116.
- Gerecht-Nir S, Dazard JE, Golan-Mashiach M, Osenberg S, Botvinnik A, Amariglio N, Domany E, Rechavi G, Givol D, Itskovitz-Eldor J (Feb 2005). "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells". Developmental Dynamics. 232 (2): 487–97. S2CID 3006762.
- Lee YS, Kim HK, Chung S, Kim KS, Dutta A (Apr 2005). "Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation". The Journal of Biological Chemistry. 280 (17): 16635–41. PMID 15722555.
- Wu L, Belasco JG (Nov 2005). "Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells". Molecular and Cellular Biology. 25 (21): 9198–208. PMID 16227573.