Leukotriene C4

Source: Wikipedia, the free encyclopedia.
(Redirected from
LTC4
)
Leukotriene C4
Names
Systematic IUPAC name
(5S,6R,7E,9E,11Z,14Z)-6-({(2R)-2-[(4S)-4-Amino-4-carboxybutanamido]-3-[(carboxymethyl)amino]-3-oxopropyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
Identifiers
3D model (
JSmol
)
ChEBI
ChemSpider
ECHA InfoCard
 100.212.805 Edit this at Wikidata
EC Number
  • 200-659-6
KEGG
MeSH Leukotriene+C4
UNII
  • InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 ☒N
    Key: GWNVDXQDILPJIG-NXOLIXFESA-N ☒N
  • InChI=1/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
    Key: GWNVDXQDILPJIG-NXOLIXFEBR
  • CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](/C(=N/CC(=O)O)/O)/N=C(\CC[C@@H](C(=O)O)N)/O
Properties
C30H47N3O9S
Molar mass 625.78 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Leukotriene C4 (LTC4) is a

CYSLTR2, triggering pulmonary vasoconstriction and bronchoconstriction.[3]

In cells of non-

haematopoietic lineage, endoplasmic reticulum (ER) stress and chemotherapy induce LTC4 biosynthesis by transcriptionally upregulating and activating the enzyme microsomal glutathione-S-transferase 2 (MGST2). ER stress and chemotherapy also trigger nuclear translocation of the two LTC4 receptors. Acting in an intracrine manner, LTC4 then elicits nuclear translocation of NADPH oxidase 4 (NOX4), ROS accumulation and oxidative DNA damage.[4] Besides being a potent lipid mediator in asthma and inflammation, LTC4 was reported to be involved in several other diseases, such as allergic airway diseases, dermatological diseases, cardiovascular diseases, liver injury, atherosclerosis and colon cancer.[5][6][7]

Eicosanoid synthesis. (Leukotrienes at right.)

References

  1. PMID 8703034
    .
  2. PMID 23063073
    .
  3. PMID 21936577
    .
  4. PMID 26656251
    .
  5. PMID 18461660
    .
  6. PMID 8228569
    .
  7. PMID 12552108
    .
Retrieved from "https://en.wikipedia.org/w/index.php?title=Leukotriene_C4&oldid=1184546868"
This page is based on the copyrighted Wikipedia article: LTC4. Articles is available under the CC BY-SA 3.0 license; additional terms may apply.Privacy Policy