LY-404187

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LY-404,187
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LY-404187
Clinical data
Other namesLY-404,187; N-2-[4-(4-cyanophenyl)phenyl]propyl-2-propanesulfonamide
ATC code
  • none
Legal status
Legal status
Identifiers
  • N-[2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide
JSmol)
  • N#Cc2ccc(cc2)-c1ccc(C(C)CNS(=O)(=O)C(C)C)cc1
  • InChI=1S/C19H28N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-7,14-15,17,19,21H,8-11,13H2,1-3H3 ☒N
  • Key:AIALBPYHYGYYRB-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

LY-404187 is an

biarylpropylsulfonamide class of AMPA receptor potentiators.[2]

LY-404187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting

BDNF in the brain.[3] It may therefore be continued on to human trials, although Eli Lilly has developed a whole family of biarylpropylsulfonamide derivatives and it is unclear at this stage which compound is most likely to be selected for further development.[4][5]

See also

References

  1. S2CID 37727259
    .
  2. S2CID 11732324
    .
  3. PMID 12353058
    .
  4. PMID 15180479
    .
  5. PMID 17504104
    .
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