Lentinan

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Lentinan
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass~ 500,000 Da
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Lentinan is a

fruit body of shiitake
mushroom (Lentinula edodes).

Chemistry

Lentinan is a β-1,3 beta-glucan with β-1,6 branching. It has a molecular weight of 500,000 Da and specific rotation of +14-22° (NaOH).

Research

Preclinical studies

An

U937.[1] Lentinan is thought to be inactive in humans when given orally and is therefore administered intravenously. The authors of an in vivo study of lentinan suggested that the compound may be active when administered orally in mice.[2]

Human clinical trials

Lentinan has been the subject of a limited number of clinical studies in cancer patients in Japan;[3][4][5][6][7][8][9][10] however, evidence of efficacy is lacking.[11][12]

Adverse effects

Lentinan has been reported to cause shiitake mushroom dermatitis.[13]

See also

  • Medicinal mushrooms

References

External links

  • Lentinan effects (antitumor and others)
  • Memorial Sloan-Kettering Cancer Center's page for Lentinan.