Leukocyte immunoglobulin-like receptors

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Leukocyte immunoglobulin-like receptors
Identifiers
SymbolLILR
Membranome17

The leukocyte immunoglobulin-like receptors (LILR) are a

immunoglobulin domains.[1]
They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells.[2] The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.

They include

A subset of LILR recognise MHC class I (also known as HLA class I in humans). The LILR family is a cluster of paired receptors with both activating and inhibitory functions.[3] Of these, the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non-classical MHC alleles with preferential binding to b2m-associated complexes. In contrast, the activating receptors LILRA1 and LILRA3 prefer b2m-independent free heavy chains of MHC class I, and in particular HLA-C alleles.[4]

See also

References

  1. PMID 15242876
    .
  2. ^ Damian Brown, Rachel L Allen, & John Trowsdale. The LILR family: modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens (2004) 64:215 http://onlinelibrary.wiley.com/doi/10.1111/j.0001-2815.2004.00290.x/pdf
  3. PMID 26802060
    .
  4. .