Leukocytosis

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Leukocytosis
Infectious disease, pathology

Leukocytosis is a condition in which the white cell (

leukocyte) count is above the normal range in the blood.[1][2] It is frequently a sign of an inflammatory response,[3] most commonly the result of infection, but may also occur following certain parasitic infections or bone tumors as well as leukemia. It may also occur after strenuous exercise, convulsions such as epilepsy, emotional stress, pregnancy and labor, anesthesia, as a side effect of medication (e.g., lithium), and epinephrine administration.[1] There are five principal types of leukocytosis:[4]

  1. Neutrophilia (the most common form)[5]
  2. Lymphocytosis
  3. Monocytosis
  4. Eosinophilia
  5. Basophilia

This increase in leukocyte (primarily neutrophils) is usually accompanied by a "left upper shift" in the ratio of immature to mature neutrophils and macrophages. The proportion of immature leukocytes increases due to proliferation and inhibition of granulocyte and monocyte precursors in the bone marrow which is stimulated by several products of inflammation including C3a and G-CSF. Although it may indicate illness, leukocytosis is considered a laboratory finding instead of a separate disease. This classification is similar to that of fever, which is also a test result instead of a disease.[citation needed] "Right shift" in the ratio of immature to mature

radiation sickness.[6]

A leukocyte count above 25 to 30 × 109/

leukoerythroblastosis, in which either immature white blood cells (acute leukemia) or mature, yet non-functional, white blood cells (chronic leukemia) are present in peripheral blood. [citation needed
]

Classification

Leukocytosis can be subcategorized by the type of white blood cell that is increased in number. Leukocytosis in which

neutrophils are elevated is neutrophilia; leukocytosis in which lymphocyte count is elevated is lymphocytosis; leukocytosis in which monocyte count is elevated is monocytosis; and leukocytosis in which eosinophil count is elevated is eosinophilia.[7]

An extreme form of leukocytosis, in which the WBC count exceeds 100,000/µL, is

blood flow. This leads to ischemic problems including transient ischemic attack and stroke.[citation needed
]

Causes

Causes of leukocytosis
Neutrophilic
leukocytosis
(neutrophilia)
Eosinophilic
leukocytosis
(eosinophilia)
Basophilic
leukocytosis
Basophilia 		(rare)[7]
Monocytosis
Lymphocytosis

Leukocytosis is very common in acutely ill patients. It occurs in response to a wide variety of conditions, including viral, bacterial, fungal, or parasitic infection, cancer, hemorrhage, and exposure to certain medications or chemicals including steroids. For lung diseases such as pneumonia and tuberculosis, WBC count is very important for the diagnosis of the disease, as leukocytosis is usually present.[citation needed]

The mechanism that causes leukocytosis can be of several forms: an increased release of leukocytes from bone marrow storage pools, decreased margination of leukocytes onto vessel walls, decreased extravasation of leukocytes from the vessels into tissues, or an increase in number of precursor cells in the marrow.[9]

Certain medications, including

beta agonists, may cause leukocytosis.[10]

Leukocytosis is an expected finding in healthy women during the post-partum period and is not a cause for alarm unless accompanied by clinical manifestations of infection.[11]

Diagnosis

Leukocyte counts

Below are blood reference ranges for various types of leukocytes/WBCs.[12] The 97.5 percentile (right limits in intervals in image, showing 95% prediction intervals) is a common limit for defining leukocytosis.[citation needed]

Treatment

While treatment is usually not necessary in the majority of cases, hyperleukocytosis (WBC count > 50 or 100 × 109/L), which can be seen in some leukemic patients, is treated to prevent leukostasis.[13][14]

See also

References

  1. ^
    ISBN 978-1-61530-250-5
    , retrieved 12 November 2011
  2. ^ TheFreeDictionary > Leukocytosis Citing: Gale Encyclopedia of Medicine, 2008 and The American Heritage Medical Dictionary, 2007
  3. ISBN 978-1-58255-724-3
    , retrieved 13 November 2011
  4. ISBN 978-0-7817-7013-2
    , retrieved 12 November 2011
  5. ISBN 0-7817-3539-4
    , retrieved 12 November 2011
  6. ^ Lutan, Vasile. Fiziopatologie medicală. Vol. 2, 31.3.2.1. Leucocitozele; "Cartea electronică: Lutan, Vasile. Fiziopatologie medicală. Vol. 2". Archived from the original on 2012-03-27. Retrieved 2011-09-25.
  7. ^
    ISBN 978-1-4160-2973-1
    8th edition.
  8. ISBN 978-0-12-385183-3
    .
  9. ^ Riley LK and Rupert J. Evaluation of Patients with Leukocytosis. 2015 Dec. Am Fam Physician. 1;92(11):1004-11.
  10. ^ Leukocytosis: Basics of Clinical Assessment, American Family Physician. November 2000.
  11. S2CID 24541975
    .
  12. ^ Specific references are found in article Reference ranges for blood tests#White blood cells 2.
  13. ^ "Leukocytosis Treatment & Management". Medscape. 8 July 2022.
  14. ^ Schiffer, Charles. "Hyperleukocytosis and leukostasis in hematologic malignancies". UpToDate.

External links

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