Levallorphan

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Levallorphan
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (−)-17-allylmorphinan-3-ol
JSmol)
  • Oc1ccc3c(c1)[C@@]24[C@H]([C@H](N(CC2)C\C=C)C3)CCCC4
  • InChI=1S/C19H25NO/c1-2-10-20-11-9-19-8-4-3-5-16(19)18(20)12-14-6-7-15(21)13-17(14)19/h2,6-7,13,16,18,21H,1,3-5,8-12H2/t16-,18-,19-/m0/s1 checkY
  • Key:OZYUPQUCAUTOBP-WDSOQIARSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Levallorphan (

analgesia.[5]

Levallorphan was formerly widely used in

full agonist of the MOR can produce greater analgesia than when the latter is used by itself.[6] The combination of levallorphan with pethidine (meperidine) was indeed used so frequently, a standardized formulation was made available, known as Pethilorfan.[7]

As an agonist of the KOR, levallorphan can produce severe mental reactions at sufficient doses including

drunkenness, delusions, paranoia, and bizarre, unusual, or disturbing dreams.[8][9][10]

See also

References

  1. ISBN 978-1-4757-2085-3
    .
  2. ISBN 978-3-88763-075-1
    .
  3. ISBN 978-94-011-4439-1
    .
  4. ISBN 978-0-07-135469-1
    .
  5. PMID 7562497
    .
  6. PMID 13805887
    .
  7. PMID 14000851
    .
  8. ISBN 978-94-011-7677-4
    .
  9. ^ American Hospital Formulary Service Drug Information. authority of the Board of Directors of the American Society of Hospital Pharmacists. 1984. p. 664.
  10. ^ Williams JB (1963). Narcotics. Wm. C. Brown Company. p. 203.


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