Lipodystrophy
Lipodystrophie | |
---|---|
Specialty | Endocrinology |
Lipodystrophy syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue.
Types
Lipodystrophy can be divided into the following types:[5]: 495–7
- Congenital lipodystrophy syndromes
- Acquired lipodystrophy syndromes
- Acquired partial lipodystrophy(Barraquer-Simons syndrome)
- Acquired generalized lipodystrophy
- Centrifugal abdominal lipodystrophy(Lipodystrophia centrifugalis abdominalis infantilis)
- Lipoatrophia annularis (Ferreira-Marques lipoatrophia)
- Localized lipodystrophy
- HIV-associated lipodystrophy
Epidemiology
Congenital lipodystrophy (due to inherited genetic defect) is estimated to be extremely rare, possibly affecting only one per million persons.[7] Acquired lipodystrophy is much more common, especially affecting persons with HIV infection.[7]
Pathogenesis
Due to an insufficient capacity of subcutaneous
Insulin injections
Lipodystrophy can appear as a lump or small dent in the
Some of the side-effects of lipodystrophy are the rejection of the injected medication, the slowing down of the absorption of the medication, or trauma which can cause bleeding that, in turn, causes rejection of the medication. In any of these scenarios, the dosage of the medication, such as insulin for diabetics, becomes impossible to gauge correctly and the treatment of the disease for which the medication is administered is impaired, thereby allowing the condition to worsen.
Antiretroviral drugs
Lipodystrophy can be a possible side effect of certain
Diagnosis
The diagnosis is a clinical one, usually established by an experienced endocrinologist.Using a
Treatment
Leptin replacement therapy with human recombinant leptin
Society and culture
Lipodystrophy United is an American organization founded and run by lipodystrophy patients to support each other and raise awareness about lipodystrophy syndromes.[19]
Lipodystrophy UK is a dedicated UK charity set up to support people affected by Lipodystrophy.[20]
March 31 is observed as the World Lipodystrophy Day.[21][22]
See also
- Keppen–Lubinsky syndrome
- Lipoedema
- Cutis laxa
References
- PMID 16054046.
- ^ "UCLA/VA Researchers discover fat gene". Archived from the original on 2018-10-06. Retrieved 2017-06-15.
- ^ PMID 27710244.
- ^ PMID 28199729.
- ISBN 978-0-7216-2921-6.
- PMID 20159315.
- ^ S2CID 195661123.
- ^ PMID 31656583.
- PMID 12095385.
- S2CID 22845453.
- ^ Physical and Biochemical Changes in HIV Disease Eric S. Daar, M.D. MedicineNet, Accessed 22 September 2007
- S2CID 19689303.
- PMID 30237235.
- PMID 11856796.
- ^ "Myalepta | European Medicines Agency". www.ema.europa.eu. 17 September 2018. Retrieved 2019-01-08.
- PMID 25470695.
- S2CID 205096489.
- ^ "The BROADEN Study: A Study of Volanesorsen (Formerly ISIS-APOCIIIRx) in Patients With Familial Partial Lipodystrophy - Full Text View - ClinicalTrials.gov". Retrieved 2018-03-31.
- ^ "Welcome to Lipodystrophy United". www.lipodystrophyunited.org. Retrieved 2018-03-31.
- ^ "Lipodystrophy UK". www.lipodystrophyuk.org. Retrieved 2020-02-29.
- ^ Inc., Ionis Pharmaceuticals. "Akcea Therapeutics Supports World Lipodystrophy Day". www.prnewswire.com (Press release). Retrieved 2018-03-31.
{{cite press release}}
:|last=
has generic name (help) - ^ "Aegerion Pharmaceuticals Observes World Lipodystrophy Day – PM360". www.pm360online.com. Retrieved 2018-03-31.