List of EC numbers (EC 4)

EC 4.1.1: Carboxy-lyases

• EC 4.1.1.1: pyruvate decarboxylase
• EC 4.1.1.2: oxalate decarboxylase
• EC 4.1.1.3: Now recognized to be two enzymes EC 7.2.4.2 [oxaloacetate decarboxylase (Na⁺ extruding)] and EC 4.1.1.112 (oxaloacetate decarboxylase).
• EC 4.1.1.4: acetoacetate decarboxylase
• EC 4.1.1.5: acetolactate decarboxylase
• EC 4.1.1.6: cis-aconitate decarboxylase
• EC 4.1.1.7: benzoylformate decarboxylase
• EC 4.1.1.8: oxalyl-CoA decarboxylase
• EC 4.1.1.9: malonyl-CoA decarboxylase
• EC 4.1.1.10: Now included with EC 4.1.1.12, aspartate 4-decarboxylase
• EC 4.1.1.11: aspartate 1-decarboxylase
• EC 4.1.1.12: aspartate 4-decarboxylase
• EC 4.1.1.13: deleted
• EC 4.1.1.14: valine decarboxylase
• EC 4.1.1.15: glutamate decarboxylase
• EC 4.1.1.16: hydroxyglutamate decarboxylase
• EC 4.1.1.17: ornithine decarboxylase
• EC 4.1.1.18: lysine decarboxylase
• EC 4.1.1.19: arginine decarboxylase
• EC 4.1.1.20: diaminopimelate decarboxylase
• EC 4.1.1.21: phosphoribosylaminoimidazole carboxylase
• EC 4.1.1.22: histidine decarboxylase
• orotidine-5′-phosphate decarboxylase
• EC 4.1.1.24: aminobenzoate decarboxylase
• EC 4.1.1.25: tyrosine decarboxylase
• EC 4.1.1.26: Now included with EC 4.1.1.28 aromatic-L-amino-acid decarboxylase
• EC 4.1.1.27: Now included with EC 4.1.1.28 aromatic-L-amino-acid decarboxylase
• aromatic-L-amino-acid decarboxylase
• sulfoalanine decarboxylase
• EC 4.1.1.30: pantothenoylcysteine decarboxylase
• EC 4.1.1.31: phosphoenolpyruvate carboxylase
• phosphoenolpyruvate carboxykinase (GTP)
• EC 4.1.1.33: diphosphomevalonate decarboxylase
• EC 4.1.1.34: dehydro-L-gulonate decarboxylase
• EC 4.1.1.35: UDP-glucuronate decarboxylase
• EC 4.1.1.36: phosphopantothenoylcysteine decarboxylase
• uroporphyrinogen decarboxylase
• EC 4.1.1.38: phosphoenolpyruvate carboxykinase (diphosphate)
• ribulose-bisphosphate carboxylase
• EC 4.1.1.40: hydroxypyruvate decarboxylase
• EC 4.1.1.41: Now EC 7.2.4.3, (S)-methylmalonyl-CoA decarboxylase
• EC 4.1.1.42: carnitine decarboxylase
• EC 4.1.1.43: phenylpyruvate decarboxylase
• EC 4.1.1.44: 4-carboxymuconolactone decarboxylase
• EC 4.1.1.45: aminocarboxymuconate-semialdehyde decarboxylase
• EC 4.1.1.46: o-pyrocatechuate decarboxylase
• EC 4.1.1.47: tartronate-semialdehyde synthase
• EC 4.1.1.48: indole-3-glycerol-phosphate synthase
• EC 4.1.1.49: phosphoenolpyruvate carboxykinase (ATP)
• EC 4.1.1.50: adenosylmethionine decarboxylase
• EC 4.1.1.51: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
• EC 4.1.1.52: 6-methylsalicylate decarboxylase
• EC 4.1.1.53: phenylalanine decarboxylase
• EC 4.1.1.54: dihydroxyfumarate decarboxylase
• EC 4.1.1.55: 4,5-dihydroxyphthalate decarboxylase
• EC 4.1.1.56: 3-oxolaurate decarboxylase
• EC 4.1.1.57: methionine decarboxylase
• EC 4.1.1.58: orsellinate decarboxylase
• EC 4.1.1.59: gallate decarboxylase
• EC 4.1.1.60: stipitatonate decarboxylase
• EC 4.1.1.61: 4-hydroxybenzoate decarboxylase
• EC 4.1.1.62: gentisate decarboxylase
• EC 4.1.1.63: protocatechuate decarboxylase
• EC 4.1.1.64: 2,2-dialkylglycine decarboxylase (pyruvate)
• EC 4.1.1.65: phosphatidylserine decarboxylase
• EC 4.1.1.66: uracil-5-carboxylate decarboxylase
• EC 4.1.1.67: UDP-galacturonate decarboxylase
• EC 4.1.1.68: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
• EC 4.1.1.69: 3,4-dihydroxyphthalate decarboxylase
• EC 4.1.1.70: Now EC 7.2.4.5, glutaconyl-CoA decarboxylase
• EC 4.1.1.71: 2-oxoglutarate decarboxylase
• EC 4.1.1.72: branched-chain-2-oxoacid decarboxylase
• EC 4.1.1.73: tartrate decarboxylase
• EC 4.1.1.74: indolepyruvate decarboxylase
• EC 4.1.1.75: 5-guanidino-2-oxopentanoate decarboxylase
• EC 4.1.1.76: arylmalonate decarboxylase
• EC 4.1.1.77: 4-oxalocrotonate decarboxylase
• EC 4.1.1.78: acetylenedicarboxylate decarboxylase
• EC 4.1.1.79: sulfopyruvate decarboxylase
• EC 4.1.1.80: 4-hydroxyphenylpyruvate decarboxylase
• EC 4.1.1.81: threonine-phosphate decarboxylase
• EC 4.1.1.82: phosphonopyruvate decarboxylase
• EC 4.1.1.83: 4-hydroxyphenylacetate decarboxylase
• EC 4.1.1.84: D-dopachrome decarboxylase
• EC 4.1.1.85: 3-dehydro-L-gulonate-6-phosphate decarboxylase
• EC 4.1.1.86: diaminobutyrate decarboxylase
• EC 4.1.1.87: malonyl-S-ACP decarboxylase
• EC 4.1.1.88: biotin-independent malonate decarboxylase
• EC 4.1.1.89: Now EC 7.2.4.4 EC 7.2.4.4, biotin-dependent malonate decarboxylase
• EC 4.1.1.90: peptidyl-glutamate 4-carboxylase
• EC 4.1.1.91: salicylate decarboxylase
• EC 4.1.1.92: indole-3-carboxylate decarboxylase
• EC 4.1.1.93: pyrrole-2-carboxylate decarboxylase
• EC 4.1.1.94: ethylmalonyl-CoA decarboxylase
• EC 4.1.1.95: L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
• EC 4.1.1.96: carboxynorspermidine decarboxylase
• EC 4.1.1.97: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase *
• EC 4.1.1.98: 4-hydroxy-3-polyprenylbenzoate decarboxylase *
• EC 4.1.1.99: phosphomevalonate decarboxylase *
• EC 4.1.1.100: prephenate decarboxylase *
• EC 4.1.1.101: malolactic enzyme *
• EC 4.1.1.102: phenacrylate decarboxylase *
• EC 4.1.1.103: γ-resorcylate decarboxylase *
• EC 4.1.1.104: 3-dehydro-4-phosphotetronate decarboxylase *
• EC 4.1.1.105: L-tryptophan decarboxylase *
• EC 4.1.1.106: fatty acid photodecarboxylase
• EC 4.1.1.107: 3,4-dihydroxyphenylacetaldehyde synthase *
• EC 4.1.1.108: 4-hydroxyphenylacetaldehyde synthase *
• EC 4.1.1.109: phenylacetaldehyde synthase *
• EC 4.1.1.110: bisphosphomevalonate decarboxylase *
• EC 4.1.1.111: siroheme decarboxylase *
• EC 4.1.1.112: oxaloacetate decarboxylase *
• EC 4.1.1.113: trans-aconitate decarboxylase *
• EC 4.1.1.114: cis-3-alkyl-4-alkyloxetan-2-one decarboxylase *
• EC 4.1.1.115: indoleacetate decarboxylase *
• EC 4.1.1.116: D-ornithine/D-lysine decarboxylase *
• EC 4.1.1.117: 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase *
• EC 4.1.1.118: isophthalyl-CoA decarboxylase *
• EC 4.1.1.119: phenylacetate decarboxylase *
• EC 4.1.1.120: 3-oxoisoapionate decarboxylase *
• EC 4.1.1.121: 3-oxoisoapionate-4-phosphate decarboxylase *

*No Wikipedia article

EC 4.1.2: Aldehyde-lyases

• EC 4.1.2.1: Now included with EC 4.1.3.16 4-hydroxy-2-oxoglutarate aldolase
• EC 4.1.2.2: ketotetrose-phosphate aldolase
• EC 4.1.2.3: deleted, was pentosealdolase.
• EC 4.1.2.4: deoxyribose-phosphate aldolase
• EC 4.1.2.5: L-threonine aldolase
• EC 4.1.2.6: Deleted, reaction is due to EC 2.1.2.1, glycine hydroxymethyltransferase
• EC 4.1.2.7: Now included with EC 4.1.2.13 fructose-bisphosphate aldolase
• EC 4.1.2.8: indole-3-glycerol-phosphate lyase
• EC 4.1.2.9: phosphoketolase
• EC 4.1.2.10: (R)-mandelonitrile lyase
• EC 4.1.2.11: hydroxymandelonitrile lyase
• EC 4.1.2.12: 2-dehydropantoate aldolase
• EC 4.1.2.13: fructose-bisphosphate aldolase
• 2-dehydro-3-deoxy-phosphogluconate aldolase
• EC 4.1.2.15: Now EC 2.5.1.54, 3-deoxy-7-phosphoheptulonate synthase
• EC 4.1.2.16: Now EC 2.5.1.55, 3-deoxy-8-phosphooctulonate synthase
• EC 4.1.2.17: L-fuculose-phosphate aldolase
• EC 4.1.2.18: 2-dehydro-3-deoxy-L-pentonate aldolase
• EC 4.1.2.19: rhamnulose-1-phosphate aldolase
• EC 4.1.2.20: 2-dehydro-3-deoxyglucarate aldolase
• EC 4.1.2.21: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
• EC 4.1.2.22: fructose-6-phosphate phosphoketolase
• EC 4.1.2.23: 3-deoxy-D-manno-octulosonate aldolase
• EC 4.1.2.24: dimethylaniline-N-oxide aldolase
• EC 4.1.2.25: dihydroneopterin aldolase
• EC 4.1.2.26: phenylserine aldolase
• EC 4.1.2.27: sphinganine-1-phosphate aldolase
• EC 4.1.2.28: 2-dehydro-3-deoxy-D-pentonate aldolase
• EC 4.1.2.29: 5-dehydro-2-deoxyphosphogluconate aldolase
• EC 4.1.2.30: Now EC 1.14.14.32}, 17α-hydroxyprogesterone deacetylase
• EC 4.1.2.31: Now included with EC 4.1.3.16 4-hydroxy-2-oxoglutarate aldolase
• EC 4.1.2.32: trimethylamine-oxide aldolase
• EC 4.1.2.33: fucosterol-epoxide lyase
• EC 4.1.2.34: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
• EC 4.1.2.35: propioin synthase
• EC 4.1.2.36: lactate aldolase
• EC 4.1.2.37: Now covered by EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)]
• EC 4.1.2.38: benzoin aldolase
• EC 4.1.2.39: Deleted, identical to EC 4.1.2.37, hydroxynitrilase
• EC 4.1.2.40: tagatose-bisphosphate aldolase
• EC 4.1.2.41: Now included with EC 4.1.2.61, feruloyl-CoA hydratase/lyase
• EC 4.1.2.42: D-threonine aldolase
• EC 4.1.2.43: 3-hexulose-6-phosphate synthase
• EC 4.1.2.44: benzoyl-CoA-dihydrodiol lyase
• EC 4.1.2.45: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
• EC 4.1.2.46: aliphatic (R)-hydroxynitrile lyase
• EC 4.1.2.47: (S)-hydroxynitrile lyase
• EC 4.1.2.48: low-specificity L-threonine aldolase
• EC 4.1.2.49: L-allo-threonine aldolase
• EC 4.1.2.50: 6-carboxytetrahydropterin synthase
• * EC 4.1.2.50: 6-carboxytetrahydropterin synthase *
• * EC 4.1.2.51: 2-dehydro-3-deoxy-D-gluconate aldolase *
• * EC 4.1.2.52: 4-hydroxy-2-oxoheptanedioate aldolase *
• * EC 4.1.2.53: 2-keto-3-deoxy-L-rhamnonate aldolase *
• * EC 4.1.2.54: L-threo-3-deoxy-hexylosonate aldolase *
• * EC 4.1.2.55: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase *
• * EC 4.1.2.56: 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase *
• * EC 4.1.2.57: sulfofructosephosphate aldolase *
• * EC 4.1.2.58: 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase *
• * EC 4.1.2.59: dihydroneopterin phosphate aldolase *
• * EC 4.1.2.60: dihydroneopterin triphosphate aldolase *
• * EC 4.1.2.61: feruloyl-CoA hydratase/lyase *
• * EC 4.1.2.62: 5-deoxyribulose 1-phosphate aldolase *
• * EC 4.1.2.63: 2-hydroxyacyl-CoA lyase *

*No Wikipedia article

EC 4.1.3: Oxo-Acid-Lyases

• EC 4.1.3.1: isocitrate lyase
• EC 4.1.3.2: Now EC 2.3.3.9, malate synthase
• EC 4.1.3.3: N-acetylneuraminate lyase
• hydroxymethylglutaryl-CoA lyase
• EC 4.1.3.5: Now EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase
• EC 4.1.3.6: citrate (pro-3S)-lyase
• EC 4.1.3.7: Now EC 2.3.3.1, citrate (Si)-synthase
• EC 4.1.3.8: Now EC 2.3.3.8, ATP citrate synthase
• EC 4.1.3.9: Now EC 2.3.3.11, 2-hydroxyglutarate synthase
• EC 4.1.3.10: Now EC 2.3.3.7, 3-ethylmalate synthase
• EC 4.1.3.11: Now EC 2.3.3.12, 3-propylmalate synthase
• EC 4.1.3.12: Now EC 2.3.3.13, 2-isopropylmalate synthase
• EC 4.1.3.13: oxalomalate lyase
• EC 4.1.3.14: L-erythro-3-hydroxyaspartate aldolase
• EC 4.1.3.15: Now EC 2.2.1.5, 2-hydroxy-3-oxoadipate synthase
• EC 4.1.3.16: 4-hydroxy-2-oxoglutarate aldolase
• EC 4.1.3.17: 4-hydroxy-4-methyl-2-oxoglutarate aldolase
• EC 4.1.3.18: Now EC 2.2.1.6, acetolactate synthase
• EC 4.1.3.19: Now EC 2.5.1.56
• EC 4.1.3.20: Now EC 2.5.1.57
• EC 4.1.3.21: Now EC 2.3.3.14
• EC 4.1.3.22: citramalate lyase
• EC 4.1.3.23: Now EC 2.3.3.2, decylcitrate synthase
• EC 4.1.3.24: malyl-CoA lyase
• EC 4.1.3.25: (S)-citramalyl-CoA lyase
• EC 4.1.3.26: 3-hydroxy-3-isohexenylglutaryl-CoA lyase
• EC 4.1.3.27: anthranilate synthase
• EC 4.1.3.28: Now EC 2.3.3.3, citrate (Re)-synthase
• EC 4.1.3.29: Now EC 2.3.3.4, decylhomocitrate synthase
• EC 4.1.3.30: methylisocitrate lyase
• EC 4.1.3.31: Now EC 2.3.3.5, 2-methylcitrate synthase
• EC 4.1.3.32: 2,3-dimethylmalate lyase
• EC 4.1.3.33: Now EC 2.3.3.6
• EC 4.1.3.34: citryl-CoA lyase
• EC 4.1.3.35: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase
• EC 4.1.3.36: naphthoate synthase
• EC 4.1.3.37: Now EC 2.2.1.7, 1-deoxy-D-xylulose 5-phosphate synthase
• EC 4.1.3.38: aminodeoxychorismate lyase
• EC 4.1.3.39: 4-hydroxy-2-oxovalerate aldolase
• EC 4.1.3.40: chorismate lyase
• EC 4.1.3.41: 3-hydroxy-D-aspartate aldolase
• EC 4.1.3.42: (4S)-4-hydroxy-2-oxoglutarate aldolase *
• EC 4.1.3.43: 4-hydroxy-2-oxohexanoate aldolase *
• EC 4.1.3.44: tRNA 4-demethylwyosine synthase (AdoMet-dependent) *
• EC 4.1.3.45: 3-hydroxybenzoate synthase *
• EC 4.1.3.46: (R)-citramalyl-CoA lyase *

*No Wikipedia article

EC 4.1.99: Other Carbon-Carbon Lyases

• EC 4.1.99.1: tryptophanase
• EC 4.1.99.2: tyrosine phenol-lyase
• deoxyribodipyrimidine photo-lyase
• EC 4.1.99.4: Now EC 3.5.99.7, 1-aminocyclopropane-1-carboxylate deaminase
• EC 4.1.99.5: octadecanal decarbonylase
• EC 4.1.99.6: Now EC 4.2.3.6, trichodiene synthase
• EC 4.1.99.7: Now EC 4.2.3.9, aristolochene synthase
• EC 4.1.99.8: Now EC 4.2.3.14, pinene synthase
• EC 4.1.99.9: Now EC 4.2.3.15, myrcene synthase
• EC 4.1.99.10: Now EC 4.2.3.16, (4S)-limonene synthase
• EC 4.1.99.11: benzylsuccinate synthase
• EC 4.1.99.12: 3,4-dihydroxy-2-butanone-4-phosphate synthase
• EC 4.1.99.13: (6-4)DNA photolyase
• EC 4.1.99.14: spore photoproduct lyase
• EC 4.1.99.15: The activity is covered by EC 4.1.99.14, spore photoproduct lyase
• EC 4.1.99.16: geosmin synthase
• EC 4.1.99.17: phosphomethylpyrimidine synthase
• EC 4.1.99.18: Now known to be catalysed by the combined effect of EC 4.1.99.22, GTP 3,8-cyclase, and EC 4.6.1.17, cyclic pyranopterin monophosphate synthase
• EC 4.1.99.19: 2-iminoacetate synthase
• EC 4.1.99.20: 3-amino-4-hydroxybenzoate synthase *
• EC 4.1.99.21: Now EC 4.2.3.153 (5-formylfuran-3-yl)methyl phosphate synthase.
• EC 4.1.99.22: GTP 3′,8-cyclase *
• EC 4.1.99.23: 5-hydroxybenzimidazole synthase *
• EC 4.1.99.24: L-tyrosine isonitrile synthase *
• EC 4.1.99.25: L-tryptophan isonitrile synthase *
• EC 4.1.99.26: 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one *

*No Wikipedia article

EC 4.2: Carbon-Oxygen Lyases

EC 4.2.1: Hydro-lyases

• carbonic anhydrase
• fumarate hydratase
• aconitate hydratase
• EC 4.2.1.4: Now known to be a partial reaction catalysed by EC 4.2.1.3, aconitate hydratase
• EC 4.2.1.5: arabinonate dehydratase
• EC 4.2.1.6: galactonate dehydratase
• EC 4.2.1.7: altronate dehydratase
• EC 4.2.1.8: mannonate dehydratase
• EC 4.2.1.9: dihydroxy-acid dehydratase
• EC 4.2.1.10: 3-dehydroquinate dehydratase
• phosphopyruvate hydratase
  (enolase)
• EC 4.2.1.12: phosphogluconate dehydratase
• EC 4.2.1.13: Now EC 4.3.1.17, L-serine ammonia-lyase
• EC 4.2.1.14: Now EC 4.3.1.18, D-serine ammonia-lyase
• EC 4.2.1.15: Identical with EC 4.4.1.1 cystathionine γ-lyase
• EC 4.2.1.16: Now EC 4.3.1.19, threonine ammonia-lyase
• EC 4.2.1.17: enoyl-CoA hydratase
• EC 4.2.1.18: methylglutaconyl-CoA hydratase
• EC 4.2.1.19: imidazoleglycerol-phosphate dehydratase
• EC 4.2.1.20: tryptophan synthase
• EC 4.2.1.21: Now EC 4.2.1.22 cystathionine β-synthase
• cystathionine β-synthase
• EC 4.2.1.23: deleted, the reaction was due to a side-reaction of EC 4.2.1.22 cystathionine β-synthase
• porphobilinogen synthase
• EC 4.2.1.25: L-arabinonate dehydratase
• EC 4.2.1.26: identical to EC 4.3.1.9, glucosaminate ammonia-lyase
• EC 4.2.1.27: acetylenecarboxylate hydratase
• EC 4.2.1.28: propanediol dehydratase
• EC 4.2.1.29: Now EC 4.99.1.6, indoleacetaldoxime dehydratase
• EC 4.2.1.30: glycerol dehydratase
• EC 4.2.1.31: maleate hydratase
• EC 4.2.1.32: L(+)-tartrate dehydratase
• 3-isopropylmalate dehydratase
• EC 4.2.1.34: (S)-2-methylmalate dehydratase
• EC 4.2.1.35: (R)-2-methylmalate dehydratase
• EC 4.2.1.36: homoaconitate hydratase
• EC 4.2.1.37: Now EC 3.3.2.4, trans-epoxysuccinate hydrolase
• EC 4.2.1.38: Now EC 4.3.1.20, erythro-3-hydroxyaspartate ammonia-lyase
• EC 4.2.1.39: gluconate dehydratase
• EC 4.2.1.40: glucarate dehydratase
• EC 4.2.1.41: 5-dehydro-4-deoxyglucarate dehydratase
• EC 4.2.1.42: galactarate dehydratase
• EC 4.2.1.43: 2-dehydro-3-deoxy-L-arabinonate dehydratase
• EC 4.2.1.44: myo-inosose-2 dehydratase
• EC 4.2.1.45: CDP-glucose 4,6-dehydratase
• EC 4.2.1.46: dTDP-glucose 4,6-dehydratase
• EC 4.2.1.47: GDP-mannose 4,6-dehydratase
• EC 4.2.1.48: D-glutamate cyclase
• urocanate hydratase
• EC 4.2.1.50: pyrazolylalanine synthase
• EC 4.2.1.51: prephenate dehydratase
• EC 4.2.1.52: Now EC 4.3.3.7, 4-hydroxy-2,3,4,5-tetrahydrodipicolinate synthase.
• EC 4.2.1.53: oleate hydratase
• EC 4.2.1.54: lactoyl-CoA dehydratase
• EC 4.2.1.55: 3-hydroxybutyryl-CoA dehydratase
• EC 4.2.1.56: itaconyl-CoA hydratase
• EC 4.2.1.57: isohexenylglutaconyl-CoA hydratase
• EC 4.2.1.58: The reaction described is covered by EC 4.2.1.59
• EC 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
• EC 4.2.1.60: 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
• EC 4.2.1.61: The reaction described is covered by EC 4.2.1.59.
• 5α-hydroxysteroid dehydratase
• EC 4.2.1.63: Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10)
• EC 4.2.1.64: Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10)
• EC 4.2.1.65: 3-cyanoalanine hydratase
• EC 4.2.1.66: cyanide hydratase
• EC 4.2.1.67: D-fuconate dehydratase
• EC 4.2.1.68: L-fuconate dehydratase
• EC 4.2.1.69: cyanamide hydratase
• EC 4.2.1.70: pseudouridylate synthase
• EC 4.2.1.71: identical to EC 4.2.1.27, acetylenecarboxylate hydratase
• EC 4.2.1.72: Now EC 4.1.1.78, acetylenedicarboxylate decarboxylase
• EC 4.2.1.73: protoaphin-aglucone dehydratase (cyclizing)
• EC 4.2.1.74: long-chain-enoyl-CoA hydratase
• uroporphyrinogen-III synthase
• EC 4.2.1.76: UDP-glucose 4,6-dehydratase
• EC 4.2.1.77: trans-L-3-hydroxyproline dehydratase
• EC 4.2.1.78: (S)-norcoclaurine synthase
• EC 4.2.1.79: 2-methylcitrate dehydratase
• EC 4.2.1.80: 2-oxopent-4-enoate hydratase
• D(-)-tartrate dehydratase
• EC 4.2.1.82: xylonate dehydratase
• EC 4.2.1.83: 4-oxalmesaconate hydratase
• EC 4.2.1.84: nitrile hydratase
• EC 4.2.1.85: dimethylmaleate hydratase
• EC 4.2.1.86: identical to EC 4.2.1.98, 16α-hydroxyprogesterone dehydratase
• EC 4.2.1.87: octopamine dehydratase
• EC 4.2.1.88: synephrine dehydratase
• EC 4.2.1.89: The activity has now been shown to be due to EC 2.8.3.21, L-carnitine CoA-transferase and EC 4.2.1.149, crotonobetainyl-CoA hydratase
• EC 4.2.1.90: L-rhamnonate dehydratase
• EC 4.2.1.91: arogenate dehydratase
• EC 4.2.1.92: hydroperoxide dehydratase
• EC 4.2.1.93: ATP-dependent NAD(P)H-hydrate dehydratase
• EC 4.2.1.94: scytalone dehydratase
• EC 4.2.1.95: kievitone hydratase
• EC 4.2.1.96: 4a-hydroxytetrahydrobiopterin dehydratase
• EC 4.2.1.97: phaseollidin hydratase
• 16α-hydroxyprogesterone dehydratase
• EC 4.2.1.99: 2-methylisocitrate dehydratase
• EC 4.2.1.100: cyclohexa-1,5-dienecarbonyl-CoA hydratase
• EC 4.2.1.101: Now included with EC 4.1.2.61, feruloyl-CoA hydratase/lyase
• EC 4.2.1.102: Now EC 4.2.1.100, cyclohexa-1,5-dienecarbonyl-CoA hydratase
• EC 4.2.1.103: cyclohexyl-isocyanide hydratase
• cyanase
• EC 4.2.1.105: 2-hydroxyisoflavanone dehydratase
• bile-acid 7α-dehydratase
• 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase
• EC 4.2.1.108: ectoine synthase
• EC 4.2.1.109: methylthioribulose 1-phosphate dehydratase
• EC 4.2.1.110: aldos-2-ulose dehydratase
• EC 4.2.1.111: 1,5-anhydro-D-fructose dehydratase
• EC 4.2.1.112: acetylene hydratase
• EC 4.2.1.113: o-succinylbenzoate synthase
• EC 4.2.1.114: methanogen homoaconitase
• EC 4.2.1.115: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
• EC 4.2.1.116: 3-hydroxypropionyl-CoA dehydratase
• EC 4.2.1.117: 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
• EC 4.2.1.118: 3-dehydroshikimate dehydratase
• EC 4.2.1.119: enoyl-CoA hydratase 2
• EC 4.2.1.120: 4-hydroxybutanoyl-CoA dehydratase
• EC 4.2.1.121: colneleate synthase
• EC 4.2.1.122: tryptophan synthase (indole-salvaging)
• EC 4.2.1.123: tetrahymanol synthase
• EC 4.2.1.124: arabidiol synthase
• EC 4.2.1.125: dammarenediol II synthase
• EC 4.2.1.126: N-acetylmuramic acid 6-phosphate etherase
• EC 4.2.1.127: linalool dehydratase
• EC 4.2.1.128: lupan-3β,20-diol synthase
• squalene—hopanol cyclase
• EC 4.2.1.130: D-lactate dehydratase
• EC 4.2.1.131: carotenoid 1,2-hydratase
• EC 4.2.1.132: 2-hydroxyhexa-2,4-dienoate hydratase
• EC 4.2.1.133: copal-8-ol diphosphate hydratase
• very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
• EC 4.2.1.135: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
• EC 4.2.1.136: ADP-dependent NAD(P)H-hydrate dehydratase
• EC 4.2.1.137: sporulenol synthase
• EC 4.2.1.138: (+)-Caryolan-1-ol synthase
• EC 4.2.1.139: pterocarpan synthase *
• EC 4.2.1.140: gluconate/galactonate dehydratase *
• EC 4.2.1.141: 2-dehydro-3-deoxyD-arabinonate dehydratase *
• EC 4.2.1.142: 5′-oxoaverantin cyclase *
• EC 4.2.1.143: versicolorin B synthase *
• EC 4.2.1.144: 3-amino-5-hydroxybenzoate synthase *
• EC 4.2.1.145: capreomycidine synthase *
• EC 4.2.1.146: L-galactonate dehydratase *
• EC 4.2.1.147: 5,6,7,8-tetrahydromethanopterin hydro-lyase *
• EC 4.2.1.148: 2-methylfumaryl-CoA hydratase *
• EC 4.2.1.149: crotonobetainyl-CoA hydratase *
• EC 4.2.1.150: short-chain-enoyl-CoA hydratase *
• EC 4.2.1.151: chorismate dehydratase *
• EC 4.2.1.152: hydroperoxy icosatetraenoate dehydratase *
• EC 4.2.1.153: 3-methylfumaryl-CoA hydratase *
• EC 4.2.1.154: tetracenomycin F2 cyclase *
• EC 4.2.1.155: (methylthio)acryloyl-CoA hydratase *
• EC 4.2.1.156: L-talarate dehydratase *
• EC 4.2.1.157: (R)-2-hydroxyisocaproyl-CoA dehydratase *
• EC 4.2.1.158: galactarate dehydratase (D-threo-forming) *
• EC 4.2.1.159: dTDP-4-dehydro-6-deoxy-α-glucopyranose 2,3-dehydratase *
• EC 4.2.1.160: 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase *
• EC 4.2.1.161: bisanhydrobacterioruberin hydratase *
• EC 4.2.1.162: 6-deoxy-6-sulfo-D-gluconate dehydratase *
• EC 4.2.1.163: 2-oxo-hept-4-ene-1,7-dioate hydratase *
• EC 4.2.1.164: dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase *
• EC 4.2.1.165: chlorophyllide a 3¹-hydratase *
• EC 4.2.1.166: phosphinomethylmalate isomerase *
• EC 4.2.1.167: (R)-2-hydroxyglutaryl-CoA dehydratase *
• EC 4.2.1.168: GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase *
• EC 4.2.1.169: 3-vinyl bacteriochlorophyllide d 3¹-hydratase *
• EC 4.2.1.170: 2-(ω-methylthio)alkylmalate dehydratase *
• EC 4.2.1.171: cis-L-3-hydroxyproline dehydratase *
• EC 4.2.1.172: trans-4-hydroxy-L-proline dehydratase *
• EC 4.2.1.173: ent-8α-hydroxylabd-13-en-15-yl diphosphate synthase *
• EC 4.2.1.174: peregrinol diphosphate synthase *
• EC 4.2.1.175: (R)-3-(aryl)lactoyl-CoA dehydratase *
• EC 4.2.1.176: L-lyxonate dehydratase *
• EC 4.2.1.177: (2S)-3-sulfopropanediol dehydratase *

*No Wikipedia article

EC 4.2.2: Acting on Polysaccharides

• EC 4.2.2.1: hyaluronate lyase
• EC 4.2.2.2: pectate lyase
• mannuronate-specific alginate lyase
• EC 4.2.2.4: Now known to comprise two enzymes: EC 4.2.2.20, chondroitin-sulfate-ABC endolyase and EC 4.2.2.21, chondroitin-sulfate-ABC exolyase
• EC 4.2.2.5: chondroitin AC lyase
• EC 4.2.2.6: oligogalacturonide lyase
• EC 4.2.2.7: heparin lyase
• EC 4.2.2.8: heparin-sulfate lyase
• EC 4.2.2.9: pectate disaccharide-lyase
• EC 4.2.2.10: pectin lyase
• guluronate-specific alginate lyase
• EC 4.2.2.12: xanthan lyase
• EC 4.2.2.13: exo-(1→4)-α-D-glucan lyase
• EC 4.2.2.14: glucuronan lyase
• EC 4.2.2.15: anhydrosialidase
• EC 4.2.2.16: levan fructotransferase (DFA-IV-forming)
• EC 4.2.2.17: inulin fructotransferase (DFA-I-forming)
• EC 4.2.2.18: inulin fructotransferase (DFA-III-forming)
• EC 4.2.2.19: chondroitin B lyase
• EC 4.2.2.20: chondroitin-sulfate-ABC endolyase
• EC 4.2.2.21: chondroitin-sulfate-ABC exolyase
• EC 4.2.2.22: pectate trisaccharide-lyase
• EC 4.2.2.23: rhamnogalacturonan endolyase
• EC 4.2.2.24: rhamnogalacturonan exolyase
• EC 4.2.2.25: gellan lyase
• EC 4.2.2.26: oligo-alginate lyase *
• EC 4.2.2.27: pectin monosaccharide-lyase *

*No Wikipedia article

EC 4.2.3: Acting on phosphates

• EC 4.2.3.1: threonine synthase
• EC 4.2.3.2: ethanolamine-phosphate phospho-lyase
• EC 4.2.3.3: methylglyoxal synthase
• EC 4.2.3.4: 3-dehydroquinate synthase
• EC 4.2.3.5: chorismate synthase
• EC 4.2.3.6: trichodiene synthase
• EC 4.2.3.7: pentalenene synthase
• EC 4.2.3.8: casbene synthase
• EC 4.2.3.9: aristolochene synthase
• (–)-endo-fenchol synthase
• EC 4.2.3.11: sabinene-hydrate synthase
• 6-pyruvoyltetrahydropterin synthase
• (+)-δ-cadinene synthase
• EC 4.2.3.14: Now covered by EC 4.2.3.119, (–)-α-pinene synthase, and EC 4.2.3.120, (–)-β-pinene synthase
• EC 4.2.3.15: myrcene synthase
• EC 4.2.3.16: (4S)-limonene synthase
• EC 4.2.3.17: taxadiene synthase
• EC 4.2.3.18: abietadiene synthase
• EC 4.2.3.19: ent-kaurene synthase
• EC 4.2.3.20: (R)-limonene synthase
• EC 4.2.3.21: vetispiradiene synthase
• EC 4.2.3.22: germacradienol synthase
• EC 4.2.3.23: germacrene-A synthase
• EC 4.2.3.24: amorpha-4,11-diene synthase
• EC 4.2.3.25: S-linalool synthase
• EC 4.2.3.26: R-linalool synthase
• EC 4.2.3.27: isoprene synthase
• EC 4.2.3.28: ent-cassa-12,15-diene synthase
• EC 4.2.3.29: ent-sandaracopimaradiene synthase
• EC 4.2.3.30: ent-pimara-8(14),15-diene synthase
• EC 4.2.3.31: ent-pimara-9(11),15-diene synthase
• EC 4.2.3.32: levopimaradiene synthase
• EC 4.2.3.33: stemar-13-ene synthase
• EC 4.2.3.34: stemod-13(17)-ene synthase
• EC 4.2.3.35: syn-pimara-7,15-diene synthase
• EC 4.2.3.36: terpentetriene synthase
• EC 4.2.3.37: epi-isozizaene synthase
• EC 4.2.3.38: α-bisabolene synthase
• EC 4.2.3.39: epi-cedrol synthase
• EC 4.2.3.40: (Z)-γ-bisabolene synthase
• EC 4.2.3.41: elisabethatriene synthase
• EC 4.2.3.42: aphidicolan-16β-ol synthase
• EC 4.2.3.43: fusicocca-2,10(14)-diene synthase
• EC 4.2.3.44: isopimara-7,15-diene synthase
• EC 4.2.3.45: phyllocladan-16α-ol synthase
• EC 4.2.3.46: α-farnesene synthase
• EC 4.2.3.47: β-farnesene synthase
• EC 4.2.3.48: (3S,6E)-nerolidol synthase
• EC 4.2.3.49: (3R,6E)-nerolidol synthase
• EC 4.2.3.50: (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
• EC 4.2.3.51: β-phellandrene synthase (neryl-diphosphate-cyclizing)
• EC 4.2.3.52: (4S)-β-phellandrene synthase (geranyl-diphosphate-cyclizing)
• EC 4.2.3.53: (+)-endo-β-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
• (–)-endo-α-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
• EC 4.2.3.55: (S)-β-bisabolene synthase
• EC 4.2.3.56: γ-humulene synthase
• (–)-β-caryophyllene synthase
• EC 4.2.3.58: longifolene synthase
• EC 4.2.3.59: (E)-γ-bisabolene synthase
• EC 4.2.3.60: germacrene C synthase
• EC 4.2.3.61: 5-epiaristolochene synthase
• (–)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]
• EC 4.2.3.63: (+)-cubenene synthase
• EC 4.2.3.64: (+)-epicubenol synthase
• EC 4.2.3.65: zingiberene synthase
• EC 4.2.3.66: β-selinene cyclase
• EC 4.2.3.67: cis-muuroladiene synthase
• EC 4.2.3.68: β-eudesmol synthase
• EC 4.2.3.69: (+)-α-barbatene synthase
• EC 4.2.3.70: patchoulol synthase
• EC 4.2.3.71: (E,E)-germacrene B synthase
• EC 4.2.3.72: α-gurjunene synthase
• EC 4.2.3.73: valencene synthase
• EC 4.2.3.74: presilphiperfolanol synthase
• (–)-germacrene D synthase
• EC 4.2.3.76: (+)-δ-selinene synthase
• EC 4.2.3.77: (+)-germacrene D synthase
• EC 4.2.3.78: β-chamigrene synthase
• EC 4.2.3.79: thujopsene synthase
• EC 4.2.3.80: α-longipinene synthase
• EC 4.2.3.81: exo-α-bergamotene synthase
• EC 4.2.3.82: α-santalene synthase
• EC 4.2.3.83: β-santalene synthase
• EC 4.2.3.84: 10-epi-γ-eudesmol synthase
• EC 4.2.3.85: α-eudesmol synthase
• EC 4.2.3.86: 7-epi-α-selinene synthase
• EC 4.2.3.87: α-guaiene synthase
• EC 4.2.3.88: viridiflorene synthase
• EC 4.2.3.89: (+)-β-caryophyllene synthase
• EC 4.2.3.90: 5-epi-α-selinene synthase
• EC 4.2.3.91: cubebol synthase
• EC 4.2.3.92: (+)-γ-cadinene synthase
• EC 4.2.3.93: δ-guaiene synthase
• EC 4.2.3.94: γ-curcumene synthase
• (–)-α-cuprenene synthase
• EC 4.2.3.96: avermitilol synthase
• (–)-δ-cadinene synthase
• EC 4.2.3.98: (+)-T-muurolol synthase
• EC 4.2.3.99: labdatriene synthase
• EC 4.2.3.100: bicyclogermacrene synthase
• EC 4.2.3.101: 7-epi-sesquithujene synthase
• EC 4.2.3.102: sesquithujene synthase
• EC 4.2.3.103: ent-isokaurene synthase
• EC 4.2.3.104: α-humulene synthase
• EC 4.2.3.105: tricyclene synthase
• EC 4.2.3.106: (E)-β-ocimene synthase
• EC 4.2.3.107: (+)-car-3-ene synthase
• EC 4.2.3.108: 1,8-cineole synthase
• (–)-sabinene synthase
• EC 4.2.3.110: (+)-sabinene synthase
• (–)-α-terpineol synthase
• EC 4.2.3.112: (+)-α-terpineol synthase
• EC 4.2.3.113: terpinolene synthase
• EC 4.2.3.114: γ-terpinene synthase
• EC 4.2.3.115: α-terpinene synthase
• EC 4.2.3.116: (+)-camphene synthase
• (–)-camphene synthase
• EC 4.2.3.118: 2-methylisoborneol synthase
• (-)-α-pinene synthase
• (-)-β-pinene synthase
• EC 4.2.3.121: (+)-α-pinene synthase
• EC 4.2.3.122: (+)-β-pinene synthase
• EC 4.2.3.123: β-sesquiphellandrene synthase
• EC 4.2.3.124: 2-deoxy-scyllo-inosose synthase
• EC 4.2.3.125: α-muurolene synthase
• EC 4.2.3.126: γ-muurolene synthase
• EC 4.2.3.127: β-copaene synthase
• EC 4.2.3.128: β-cubebene synthase
• EC 4.2.3.129: (+)-sativene synthase
• EC 4.2.3.130: tetraprenyl-β-curcumene synthase
• EC 4.2.3.131: miltiradiene synthase
• EC 4.2.3.132: neoabietadiene synthase
• EC 4.2.3.133: α-copaene synthase
• EC 4.2.3.134: 5-phosphooxy-L-lysine phospho-lyase
• EC 4.2.3.135: Δ⁶-protoilludene synthase
• EC 4.2.3.136: α-isocomene synthase
• EC 4.2.3.137: (E)-2-epi-β-caryophyllene synthase
• EC 4.2.3.138: (+)-epi-α-bisabolol synthase
• EC 4.2.3.139: valerena-4,7(11)-diene synthase
• EC 4.2.3.140: cis-abienol synthase

Enzymes from EC 4.2.3.141 on have no Wikipedia articles

• EC 4.2.3.141: sclareol synthase
• EC 4.2.3.142: 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
• EC 4.2.3.143: kunzeaol synthase
• EC 4.2.3.144: geranyllinalool synthase
• EC 4.2.3.145: ophiobolin F synthase
• EC 4.2.3.146: cyclooctat-9-en-7-ol synthase
• EC 4.2.3.147: pimaradiene synthase
• EC 4.2.3.148: cembrene C synthase
• EC 4.2.3.149: nephthenol synthase
• EC 4.2.3.150: cembrene A synthase
• EC 4.2.3.151: pentamethylcyclopentadecatrienol synthase
• EC 4.2.3.152: 2-epi-5-epi-valiolone synthase
• EC 4.2.3.153: (5-formylfuran-3-yl)methyl phosphate synthase
• EC 4.2.3.154: demethyl-4-deoxygadusol synthase
• EC 4.2.3.155: 2-epi-valiolone synthase
• EC 4.2.3.156: hydroxysqualene synthase
• EC 4.2.3.157: (+)-isoafricanol synthase
• EC 4.2.3.158: (–)-spiroviolene synthase
• EC 4.2.3.159: tsukubadiene synthase
• EC 4.2.3.160: (2S,3R,6S,9S)-(–)-protoillud-7-ene synthase
• EC 4.2.3.161: (3S)-(+)-asterisca-2(9),6-diene synthase
• EC 4.2.3.162: (–)-α-amorphene synthase
• EC 4.2.3.163: (+)-corvol ether B synthase
• EC 4.2.3.164: (+)-eremophilene synthase
• EC 4.2.3.165: (1R,4R,5S)-(–)-guaia-6,10(14)-diene synthase
• EC 4.2.3.166: (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
• EC 4.2.3.167: dolabella-3,7-dien-18-ol synthase
• EC 4.2.3.168: dolathalia-3,7,11-triene synthase
• EC 4.2.3.169: 7-epi-α-eudesmol synthase
• EC 4.2.3.170: 4-epi-cubebol synthase
• EC 4.2.3.171: (+)-corvol ether A synthase
• EC 4.2.3.172: 10-epi-juneol synthase
• EC 4.2.3.173: τ-cadinol synthase
• EC 4.2.3.174: (2E,6E)-hedycaryol synthase
• EC 4.2.3.175: 10-epi-cubebol synthase
• EC 4.2.3.176: sesterfisherol synthase
• EC 4.2.3.177: β-thujene synthase
• EC 4.2.3.178: stellata-2,6,19-triene synthase
• EC 4.2.3.179: guaia-4,6-diene synthase
• EC 4.2.3.180: pseudolaratriene synthase
• EC 4.2.3.181: selina-4(15),7(11)-diene synthase
• EC 4.2.3.182: pristinol synthase
• EC 4.2.3.183: nezukol synthase
• EC 4.2.3.184: 5-hydroxy-α-gurjunene synthase
• EC 4.2.3.185: ent-atiserene synthase
• EC 4.2.3.186: ent-13-epi-manoyl oxide synthase
• EC 4.2.3.187: (2Z,6E)-hedycaryol synthase
• EC 4.2.3.188: β-geranylfarnesene synthase
• EC 4.2.3.189: 9,13-epoxylabd-14-ene synthase
• EC 4.2.3.190: manoyl oxide synthase
• EC 4.2.3.191: cycloaraneosene synthase
• EC 4.2.3.192: labda-7,13(16),14-triene synthase
• EC 4.2.3.193: (12E)-labda-8(17),12,14-triene synthase
• EC 4.2.3.194: (–)-drimenol synthase
• EC 4.2.3.195: rhizathalene A synthase
• EC 4.2.3.196: dolabradiene synthase
• EC 4.2.3.197: eudesmane-5,11-diol synthase
• EC 4.2.3.198: α-selinene synthase
• EC 4.2.3.199: (–)-5-epieremophilene synthase
• EC 4.2.3.200: β-pinacene synthase
• EC 4.2.3.201: hydropyrene synthase
• EC 4.2.3.202: hydropyrenol synthase
• EC 4.2.3.203: isoelisabethatriene synthase
• EC 4.2.3.204: valerianol synthase
• EC 4.2.3.205: sodorifen synthase

EC 4.2.99: Other Carbon-Oxygen Lyases

• EC 4.2.99.1: Now EC 4.2.2.1, hyaluronate lyase
• EC 4.2.99.2: Now EC 4.2.3.1, threonine synthase
• EC 4.2.99.3: Now EC 4.2.2.2, pectate lyase
• EC 4.2.99.4: Now EC 4.2.2.3, poly(β-D-mannuronate) lyase
• EC 4.2.99.5: deleted
• EC 4.2.99.6: Now included with EC 4.2.2.4 (chondroitin ABC lyase) and EC 4.2.2.5 (chondroitin AC lyase)
• EC 4.2.99.7: Now EC 4.2.3.2, ethanolamine-phosphate phospho-lyase
• EC 4.2.99.8: Now EC 2.5.1.47, cysteine synthase
• EC 4.2.99.9: Now EC 2.5.1.48, cystathionine γ-synthase
• EC 4.2.99.10: Now EC 2.5.1.49 EC 2.5.1.49, O-acetylhomoserine aminocarboxypropyltransferase
• EC 4.2.99.11: Now EC 4.2.3.3, methylglyoxal synthase
• EC 4.2.99.12: carboxymethyloxysuccinate lyase
• EC 4.2.99.13: Now EC 2.5.1.50, zeatin 9-aminocarboxyethyltransferase
• EC 4.2.99.14: Now EC 2.5.1.51, β-pyrazolylalanine synthase
• EC 4.2.99.15: Now EC 2.5.1.52, L-mimosine synthase
• EC 4.2.99.16: Now EC 2.5.1.53, uracilylalanine synthase
• EC 4.2.99.17: Listed as EC 2.5.1.51, β-pyrazolylalanine synthase
• EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase
• EC 4.2.99.19: Now EC 4.4.1.23, 2-hydroxypropyl-CoM lyase
• EC 4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
• EC 4.2.99.21: isochorismate lyase
• EC 4.2.99.22: tuliposide A-converting enzyme *
• EC 4.2.99.23: tuliposide B-converting enzyme *
• EC 4.2.99.24: thebaine synthase *

*No Wikipedia article

EC 4.3: Carbon-Nitrogen Lyases

EC 4.3.1: Ammonia-Lyases

• EC 4.3.1.1: aspartate ammonia-lyase
• EC 4.3.1.2: methylaspartate ammonia-lyase
• EC 4.3.1.3: histidine ammonia-lyase
• formiminotetrahydrofolate cyclodeaminase
• EC 4.3.1.5: Now divided into EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase)
• β-alanyl-CoA ammonia-lyase
• EC 4.3.1.7: ethanolamine ammonia-lyase
• EC 4.3.1.8: Now EC 2.5.1.61, hydroxymethylbilane synthase
• EC 4.3.1.9: glucosaminate ammonia-lyase
• EC 4.3.1.10: serine-sulfate ammonia-lyase
• EC 4.3.1.11: Deleted: inadequately characterized
• EC 4.3.1.12: ornithine cyclodeaminase
• EC 4.3.1.13: carbamoyl-serine ammonia-lyase
• EC 4.3.1.14: 3-aminobutyryl-CoA ammonia-lyase
• EC 4.3.1.15: diaminopropionate ammonia-lyase
• EC 4.3.1.16: threo-3-hydroxy-L-aspartate ammonia-lyase
• EC 4.3.1.17: L-serine ammonia-lyase
• EC 4.3.1.18: D-serine ammonia-lyase
• EC 4.3.1.19: threonine ammonia-lyase
• EC 4.3.1.20: erythro-3-hydroxy-L-aspartate ammonia-lyase
• EC 4.3.1.21: identical to EC 4.3.1.9, glucosaminate ammonia-lyase
• EC 4.3.1.22: 3,4-dihydroxyphenylalanine reductive deaminase
• EC 4.3.1.23: tyrosine ammonia-lyase
• EC 4.3.1.24: phenylalanine ammonia-lyase
• EC 4.3.1.25: phenylalanine/tyrosine ammonia-lyase
• EC 4.3.1.26: Now EC 1.21.3.9, dichlorochromopyrrolate synthase
• EC 4.3.1.27: threo-3-hydroxy-D-aspartate ammonia-lyase
• EC 4.3.1.28: L-lysine cyclodeaminase
• EC 4.3.1.29: D-glucosaminate-6-phosphate ammonia-lyase *
• EC 4.3.1.30: dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase *
• EC 4.3.1.31: L-tryptophan ammonia lyase *
• EC 4.3.1.32: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase *

*No Wikipedia article

EC 4.3.2: Amidine-Lyases

• EC 4.3.2.1: argininosuccinate lyase
• EC 4.3.2.2: adenylosuccinate lyase
• EC 4.3.2.3: ureidoglycolate lyase
• EC 4.3.2.4: purine imidazole-ring cyclase
• EC 4.3.2.5: peptidylamidoglycolate lyase
• EC 4.3.2.6: γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase
• EC 4.3.2.7: glutathione-specific γ-glutamylcyclotransferase *
• EC 4.3.2.8: γ-glutamylamine cyclotransferase *
• EC 4.3.2.9: γ-glutamylcyclotransferase *
• EC 4.3.2.10: imidazole glycerol-phosphate synthase *

*No Wikipedia article

EC 4.3.3: Amine-Lyases

• EC 4.3.3.1: 3-ketovalidoxylamine C-N-lyase
• EC 4.3.3.2: strictosidine synthase
• EC 4.3.3.3: deacetylisoipecoside synthase
• EC 4.3.3.4: deacetylipecoside synthase
• EC 4.3.3.5: 4′-demethylrebeccamycin synthase
• EC 4.3.3.6: pyridoxal 5′-phosphate synthase (glutamine hydrolysing)
• 4-hydroxy-tetrahydrodipicolinate synthase

EC 4.3.99: Other Carbon-Nitrogen Lyases

• EC 4.3.99.1: Now EC 4.2.1.104, cyanate hydratase
• EC 4.3.99.2: Now EC 7.2.4.1, carboxybiotin decarboxylase
• EC 4.3.99.3: 7-carboxy-7-deazaguanine synthase
• EC 4.3.99.4: choline trimethylamine-lyase *

*No Wikipedia article

EC 4.4: Carbon-Sulfur Lyases

EC 4.4.1: Carbon-sulfur lyases (only sub-subclass identified to date)

• cystathionine γ-lyase
• EC 4.4.1.2: homocysteine desulfhydrase
• EC 4.4.1.3: dimethylpropiothetin dethiomethylase
• alliin lyase
• EC 4.4.1.5: lactoylglutathione lyase
• EC 4.4.1.6: Now included in EC 4.4.1.13, cysteine-S-conjugate β-lyase
• EC 4.4.1.7: Now included with EC 2.5.1.18 glutathione transferase
• EC 4.4.1.8: Now included in EC 4.4.1.13, cysteine-S-conjugate β-lyase
• EC 4.4.1.9: L-3-cyanoalanine synthase
• EC 4.4.1.10: cysteine lyase
• methionine γ-lyase
• EC 4.4.1.12: deleted: activity due to EC 2.3.3.15, sulfoacetaldehyde acetyltransferase
• cysteine-S-conjugate β-lyase
• 1-aminocyclopropane-1-carboxylate synthase
• EC 4.4.1.15: D-cysteine desulfhydrase
• EC 4.4.1.16: selenocysteine lyase
• EC 4.4.1.17: holocytochrome-c synthase
• EC 4.4.1.18: Now EC 1.8.3.5, prenylcysteine oxidase
• EC 4.4.1.19: phosphosulfolactate synthase
• EC 4.4.1.20: leukotriene-C₄ synthase
• EC 4.4.1.21: S-ribosylhomocysteine lyase
• EC 4.4.1.22: S-(hydroxymethyl)glutathione synthase
• EC 4.4.1.23: 2-hydroxypropyl-CoM lyase
• (2R)-sulfolactate sulfo-lyase
• EC 4.4.1.25: L-cysteate sulfo-lyase
• EC 4.4.1.26: olivetolic acid cyclase
• EC 4.4.1.27: Now EC 3.13.1.5, carbon disulfide hydrolase

*No Wikipedia article

EC 4.5: Carbon-Halide Lyases

EC 4.5.1: Carbon-halide lyases (only sub-subclass identified to date)

• EC 4.5.1.1: DDT-dehydrochlorinase
• EC 4.5.1.2: 3-chloro-D-alanine dehydrochlorinase
• EC 4.5.1.3: dichloromethane dehalogenase
• EC 4.5.1.4: L-2-amino-4-chloropent-4-enoate dehydrochlorinase
• EC 4.5.1.5: S-carboxymethylcysteine synthase

EC 4.6: Phosphorus-Oxygen Lyases

EC 4.6.1: Phosphorus-oxygen lyases (only sub-subclass identified to date)

• adenylate cyclase
• EC 4.6.1.2: guanylate cyclase
• EC 4.6.1.3: Now EC 4.2.3.4, 3-dehydroquinate synthase
• EC 4.6.1.4: Now EC 4.2.3.5, chorismate synthase
• EC 4.6.1.5: Now EC 4.2.3.7, pentalenene synthase
• EC 4.6.1.6: cytidylate cyclase
• EC 4.6.1.7: Now EC 4.2.3.8, casbene synthase
• EC 4.6.1.8: Now EC 4.2.3.10, (-)-endo-fenchol synthase
• EC 4.6.1.9: Now Now EC 4.2.3.11, sabinene-hydrate synthase
• EC 4.6.1.10: Now EC 4.2.3.12, 6-pyruvoyltetrahydropterin synthase
• EC 4.6.1.11: Now EC 4.2.3.13, (+)-δ-cadinene synthase
• EC 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
• EC 4.6.1.13: phosphatidylinositol diacylglycerol-lyase
• EC 4.6.1.14: glycosylphosphatidylinositol diacylglycerol-lyase
• EC 4.6.1.15: FAD-AMP lyase (cyclizing)
• EC 4.6.1.16: tRNA-intron lyase
• EC 4.6.1.17: cyclic pyranopterin monophosphate synthase *
• EC 4.6.1.18: pancreatic ribonuclease *
• EC 4.6.1.19: ribonuclease T₂ *
• EC 4.6.1.20: ribonuclease U₂ *
• EC 4.6.1.21: Enterobacter ribonuclease *
• EC 4.6.1.22: Bacillus subtilis ribonuclease *
• EC 4.6.1.23: ribotoxin *
• EC 4.6.1.24: ribonuclease T₁ *
• EC 4.6.1.25: bacteriophage T₄ restriction endoribonuclease RegB *

*No Wikipedia article

EC 4.7: Carbon-phosphorus lyases

EC 4.7.1: Carbon-phosphorus lyases (only sub-subclass identified to date)

• EC 4.7.1.1 α-D ribose 1-methylphosphonate 5-phosphate C-P-lyase *

*No Wikipedia article

EC 4.8: Nitrogen-oxygen lyases

EC 4.8.1: Hydro-lyases

• EC 4.8.1.1: L-piperazate synthase *
• EC 4.8.1.2: aliphatic aldoxime dehydratase *
• EC 4.8.1.3: indoleacetaldoxime dehydratase *
• EC 4.8.1.4: phenylacetaldoxime dehydratase *

*No Wikipedia article

EC 4.98: ATP-independent chelatases

EC 4.98.1: Forming coordination complexes

• EC 4.98.1.1: protoporphyrin ferrochelatase

EC 4.99: Other Lyases

EC 4.99.1: Sole sub-subclass for lyases that do not belong in the other subclasses

• EC 4.99.1.1: Now EC 4.98.1.1
• EC 4.99.1.2: alkylmercury lyase
• EC 4.99.1.3: sirohydrochlorin cobaltochelatase
• EC 4.99.1.4: sirohydrochlorin ferrochelatase
• EC 4.99.1.5: Now EC 4.8.1.2, aliphatic aldoxime dehydratase
• EC 4.99.1.6: Now EC 4.8.1.3, indoleacetaldoxime dehydratase
• EC 4.99.1.7: Now EC 4.8.1.4, phenylacetaldoxime dehydratase
• EC 4.99.1.8: heme ligase
• EC 4.99.1.9:: coproporphyrin ferrochelatase *
• EC 4.99.1.10: magnesium dechelatase *
• EC 4.99.1.11: sirohydrochlorin nickelchelatase *
• EC 4.99.1.12: pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase *

*No Wikipedia article

References