List of medical ethics cases
Some cases have been remarkable for starting broad discussion and for setting precedent in medical ethics.
Research
Research | |||||
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case | country | location | year | summary | |
Psychosurgery | 1880s | Psychosurgery (also called neurosurgery for mental disorder) has a long history. During the 1960s and 1970s, it became the subject of increasing public concern and debate, culminating in the US with congressional hearings. Particularly controversial was the work of Harvard neurosurgeon Vernon Mark and psychiatrist Frank Ervin, who wrote a book, Violence and the Brain, in 1970.[1] The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in 1977 endorsed the continued limited use of psychosurgical procedures.[1][2] Since then, a few facilities in some countries have continued to use psychosurgery on small numbers of patients. In the US and other Western countries, the number of operations has further declined over the past 30 years, a period during which there have been no major advances in ablative psychosurgery.[3] | |||
Surgical removal of body parts to try to improve mental health | United States | New Jersey | 1920s | Controversial psychiatrist Henry Cotton at Trenton State Hospital in New Jersey became convinced that insanity was fundamentally a toxic disorder and he surgically removed body parts to try to improve mental health.[4] | |
The Monster Study
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United States | Iowa | 1939 | The Monster Study is the name given to a San Jose Mercury News in 2001, and a book was written. On 17 August 2007, six of the orphan children were awarded $925,000 by the State of Iowa for lifelong psychological and emotional scars caused by six months of torment during the Iowa University experiment. Although none of the children became stutterers, some became self-conscious and reluctant to speak.[5] A spokesman for the University of Iowa called the experiment "regrettable".
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Medical Experimentation on Black Americans[6] | United States | Various | Occurred over many decades | There has been a long history of African Americans. From the era of slavery, when atrocities were committed on black women by J. Marion Sims, to the present day, Black Americans have been unwitting subjects of medical experimentation.[7][8] Author Harriet Washington argues that "diverse forms of racial discrimination have shaped both the relationship between white physicians and black patients and the attitude of the latter towards modern medicine in general."[9]
In the 1960s, civil rights ideas. See The Protest Psychosis .
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Plutonium injections | United States | 1945–1947 | Eighteen people were injected with plutonium by Manhattan Project doctors; the most notorious of them, Albert Stevens, received more radiation than any other living person. None of the patients were told about the experiment, nor did the doctors ask for their consent. See Eileen Welsome's book The Plutonium Files.[10] | ||
Doctors' Trial | United States | 1946 | German medical doctors went on criminal trial for Nazi human experimentation. See The Years of Extermination. | ||
Guatemala syphilis experiments
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U.S./ Guatemala |
1946–48 | The syphilis experiments in Guatemala were United States human experiments conducted in Guatemala from 1946 to 1948. The experiments were led by physician John Charles Cutler. They were done during the administration of American President Harry S. Truman and Guatemalan President Juan José Arévalo.[11]
Doctors infected soldiers, prostitutes, prisoners, and sexually transmitted diseases without the informed consent of the subjects, and treated most subjects with antibiotics. This resulted in at least 83 deaths.[12] In October 2010, the US formally apologized to Guatemala for conducting these experiments.
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Skid Row Cancer Study | United States | New York State | 1950s | More than 1200 homeless men from Lower Manhattan were convinced with promises of food and shelter to have their prostates biopsied by a Dr. Perry Hudson. They were not informed of possible side effects, i.e., rectal tearing and impotence. The homeless were targeted for these biopsies because the biopsies were painful and untested, and less vulnerable populations would not volunteer. | |
Radioactive iodine experiments | United States | 1950s | The University of Nebraska College of Medicine fed iodine-131 to 28 healthy infants through a gastric tube to test the concentration of iodine in the infants' thyroid glands.[14]
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Henrietta Lacks | United States | Baltimore | 1951 | A product derived from a cancer patient's specimen, HeLa is the cornerstone of an industry. Cancerous tissue was taken from her without her consent. | |
Albert Kligman's dermatology experiments | United States | Philadelphia | 1951–1974 | Clinical non-therapeutic dermatologist Albert Kligman.[15]
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Allan Memorial Institute | Canada | Montreal, Quebec | 1957–1964 | The Project MKULTRA run by the CIA. The Agency's initiative to develop drug-induced "mind control" techniques was implemented in the institute by its then-Director Donald Ewen Cameron .
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UK mental institutions | UK | 1960s | In the 1960s, there was abuse and inhumane treatment of psychiatric patients who were hidden away in institutions in the UK. Barbara Robb documented her difficult personal experience of being treated at Ely Hospital. She wrote the book Sans Everything and she used this to launch a campaign to improve or close long stay facilities. Shortly after, a long stay hospital for mentally disabled people in Cardiff was exposed by a nurse writing to the News of the World. This exposure prompted an official inquiry, which was highly critical of conditions, staff morale, and management. At the same time Michael Ignatieff and Peter Townsend both published books which exposed the poor quality of institutional care.[16] | ||
Milgram experiment | United States | 1961 | The Milgram experiment on obedience to authority figures was a series of notable social psychology experiments conducted by Yale University psychologist Stanley Milgram, which measured the willingness of study participants to obey an authority figure who instructed them to perform acts that conflicted with their personal conscience.[17] The detailed findings are discussed in his 1974 book, Obedience to Authority: An Experimental View.[18] The experiments were controversial, and considered by some scientists to be unethical and physically or psychologically abusive. Psychologist Diana Baumrind considered the experiment "harmful because it may cause permanent psychological damage and cause people to be less trusting in the future."[19] | ||
Harry Bailey's deep sleep therapy | Australia | Sydney | 1962-1979 | Controversial Australian psychiatrist Harry Bailey treated mental patients via deep sleep therapy and other methods at a Sydney mental hospital. He has been linked with the deaths of 85 patients.[20] He died by suicide before he could be punished. | |
Political abuse of psychiatry | Soviet Union, Romania, Hungary, Czechoslovakia, Yugoslavia and China |
1960s to 1980s | Psychiatrists have been involved in human rights abuses in states across the world when the definitions of mental disease were expanded to include political disobedience. People's Republic of China.[23] Psychiatric diagnoses such as the diagnosis of "sluggish schizophrenia" in political dissidents in the USSR were used for political purposes.[24] : 77
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Stanford prison experiment | United States | 1971 | The Stanford prison experiment was a study of the prison guard. The experiment was conducted in August 1971 by a team of researchers led by psychology professor Philip Zimbardo.[25] Participants took on the roles of prisoners and guards in a mock prison situated in the basement of the Stanford psychology building. Some of the prisoners were subjected to psychological torture . Many of the prisoners passively accepted psychological abuse, and Zimbardo himself permitted the abuse to continue. Two of the prisoners quit the experiment early and the entire experiment was abruptly stopped after only six days. Certain portions of the experiment were filmed and excerpts of footage are publicly available.
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Human radiation experiments | United States | 1970s | Human radiation experiments were directed by the United States Atomic Energy Commission and the Manhattan Project. In Nashville, pregnant women were given radioactive mixtures. In Cincinnati, some 200 patients were irradiated over a period of 15 years. In Chicago, 102 people received injections of strontium and cesium solutions. In Massachusetts, 74 schoolboys were fed oatmeal that contained radioactive substances. In all of these cases, the subjects did not know what was going on and did not give informed consent.[10] The government covered up most of these radiation mishaps until 1993, when President Bill Clinton ordered a change of policy. The resulting investigation was undertaken by the Advisory Committee on Human Radiation Experiments. See The Plutonium Files. | ||
Tuskegee syphilis experiment
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United States | Tuskegee, Alabama | 1972 | A 40-year experiment conducted by the U.S. Public Health Service withheld standard medical advice and treatment from a poor minority population with an easily treatable disease. The experiment targeted black male farmers who were told they needed to be treated for 'bad blood',[26] but who were, in fact, syphilitic. In addition to many fatalities, some children were born with congenital syphilis due to the study. | |
Moore v. Regents of the University of California | United States | California | 1976 | Researchers commercialized a patient's discarded body parts. The man did not authorize the use of his bodily tissues or fluids, and researchers did not obtain informed consent. He did not want his donation to generate commercial profit for private entities. | |
Eugene Landy | United States | California | 1980s | Eugene Ellsworth Landy was an American psychologist and psychotherapist best known for his unconventional 24-hour therapy as well as ethical violations concerning his treatment of Beach Boys co-founder Brian Wilson in the 1980s. In 2015, Landy's relationship with Wilson was dramatized in the biographical film Love & Mercy .
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Willowbrook State School | United States | Staten Island | 1987 | A school had been infecting disabled children in experiments for years. | |
Study 329 | Canada, United States | 12 psychiatric centers | 1994–2001 | medical ghostwriting and conflict of interest in clinical trials. In 2012 the US Justice Department fined GlaxoSmithKline $3 billion for several violations, including withholding data on paroxetine, unlawfully promoting it for adolescents, and preparing a misleading article about study 329. New Scientist wrote in 2015: "You may never have heard of it, but Study 329 changed medicine."[27]
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Death associated with psychotropic drugs | United States | Cheyenne, Wyoming | 1998 | In 1998, 60-year-old psychotropic drug.[28]
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Robert Courtney | United States | Kansas City, Missouri | 2002 | Courtney is a former pharmacist who owned and operated Research Medical Tower Pharmacy in Missouri.[32] In 2002, he was convicted of pharmaceutical fraud and sentenced to federal prison.[32] | |
Greenberg v. Miami Children's Hospital Research Institute | United States | Florida | 2003 | Patients donated tissue samples, which researchers subsequently used in a plan to generate profit. | |
GlaxoSmithKline human experiments
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Various | 2004–2012 |
In 2004 AIDS medications, some of which have potentially dangerous side effects.[33]
In 2006, GSK and the US Army were criticized for Hepatitis E vaccine experiments conducted in 2003 on 2,000 soldiers of the Nepali Army. It was said that using soldiers as volunteers is unethical because they "could easily be coerced into taking part."[34] In January 2012, GSK and two scientists who led the trials were fined approximately $240,000 in Argentina for "experimenting with human beings" and "falsifying parental authorization" during vaccine trials on 15,000 children under the age of one. Babies were recruited from poor families that visited public hospitals for medical treatment. Fourteen babies allegedly died as a result of the trials.[35] | ||
Death from prescription drugs | United States | Hull, Massachusetts | 2006 | Tufts-New England Medical Center.[36]
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University of Minnesota Research Participant Dan Markingson | United States | Minnesota | 2004 | Dan Markingson committed suicide in May 2004 while enrolled in an industry-sponsored pharmaceutical trial comparing three FDA-approved atypical antipsychotics: Seroquel (quetiapine), Zyprexa (olanzapine), and Risperdal (risperidone). Writing on the circumstances surrounding Markingson's death in the study, which was designed and funded by Seroquel manufacturer AstraZeneca, University of Minnesota Professor of Bioethics Carl Elliott noted that Markingson was enrolled in the study against the wishes of his mother, Mary Weiss, and that he was forced to choose between enrolling in the study or being involuntarily committed to a state mental institution.[37] Further investigation revealed financial ties to AstraZeneca by Markingson's psychiatrist, Dr. Stephen C. Olson, oversights and biases in AstraZeneca's trial design, and the inadequacy of university Institutional Review Board (IRB) protections for research subjects.[38] Although a 2005 FDA investigation appeared to clear the university, greater awareness of the case stemming from Elliott's 2010 article in the magazine Mother Jones resulted in a group of university faculty members sending a public letter to the Board of Regents urging an external investigation into Markingson's death.[39]
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Termination of mechanical ventilation and life support
Termination of life support | |||||
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case | country | location | year | summary | |
Betancourt v. Trinitas Hospital | United States | New Jersey | 2008 | A hospital wished to withhold treatment from someone whom it judges to have no chance of living. | |
Mordechai Dov Brody | United States | Brooklyn | 2008 | The parents of a brain-dead boy wanted to keep him on life support. | |
Cuthbertson v Rasouli | Canada | Toronto | 2013 | The wife of a brain-damaged man wanted to keep him on life support. | |
Lantz v. Coleman | United States | Connecticut | 2007 | Prison officials question whether to force-feed inmates who are on hunger strike. | |
Charlie Gard case | United Kingdom | Great Ormond Street Hospital, London, England | 2017 | After losing a UK Supreme Court case, the parents of Gard, 10 months, petitioned the EU Court in France, and lost the final appeal. They wanted the hospital to allow them to travel to the U.S. for an experimental therapy that may have provided some temporary benefit but likely would not have improved his neurological condition, due to a nucleoside bypass therapy). At the least, they wanted for the hospital to continue to provide advanced life support palliative care for their son—respiration, nutrition, hydration—or to send him home on life support to eventually die, but those requests were also denied and support was turned off on July 27, 2017. Gard died the next day.
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Tirhas Habtegiris
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United States | Texas | 2005 | The hospital removes life support from an unconscious immigrant from Eritrea against her family's wishes. The family are in a foreign country and unable to travel. | |
Rom Houben | Belgium | 2010 | A man seems to be in a persistent vegetative state, and after 23 years a communication test is conducted. | ||
Sun Hudson case | United States | Texas | 2004 | An infant is removed from life support against his mother's wishes. | |
Baby K | United States | Virginia | 1992 | The mother of an anencephalic baby wishes to keep the child on life support perpetually. | |
Jesse Koochin | United States | Salt Lake City | 2004 | Parents wish to keep a child on life support. | |
Spiro Nikolouzos case | United States | Texas | 2005 | A family wishes to keep life support for a man in a persistent vegetative state. | |
David Vetter | United States | Texas | 1984 | A boy dies at age 12 after living a lifetime with highly unusual medical care in a sterile environment. | |
Jahi McMath case | United States | California | 2013 | A teenaged girl is declared brain-dead and her family wishes to maintain her body on mechanical ventilation perpetually.
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Withholding life-prolonging medical treatment
Withholding life-prolonging treatment | |||||
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case | country | location | year | summary | |
Baby Doe Law | United States | New York | 1983 | The parents of a child born with severe birth defects request the right to refuse treatment and keep the child off life support. | |
Baby M | Australia | Melbourne | 1989 | Parents and doctors agreed to withhold life-prolonging measures of severely disabled newborn baby, including surgeries and medication, while Right to Life activists claimed the baby was murdered.[40] |
Informed consent to medical treatment
Informed consent to medical treatment | |||||
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case | country | location | year | summary | |
Christiane Völling | Germany | 2011 | Informed consent and involuntary sex reassignment in the case of an adult intersex woman. | ||
Gillick competence | England | 1985 | The right of minors to request contraception from their doctor without parental consent. |
Person wishes for assisted suicide
Assisted suicide | |||||
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case | country | location | year | summary | |
Betty and George Coumbias | Canada | Vancouver, British Columbia
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2007 | A couple request the legal right to commit suicide together, although only the husband was ill. | |
Dax Cowart | United States | 1973 | A man who suffered severe burns requests the right to die. | ||
Giovanni Nuvoli | Italy | Alghero, Sardinia | 2007 | A man in pain requests a legal right to die. | |
Sue Rodriguez | Canada | Victoria, British Columbia | 1991 | A woman requests a right to assisted suicide. | |
Ramón Sampedro | Spain | Galicia
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1998 | For 29 years a man requests his right to assisted suicide. | |
Aruna Shanbaug case | India | Karnataka | 2011 | A writ petition under Article 32 of the Constitution has been filed on behalf of the petitioner Aruna Ramachandra Shanbaug by one Ms. Pinki Virani of Mumbai, claiming to be a next friend. | |
Piergiorgio Welby | Italy | Rome | 2006 | A patient requests a legal right to die. |
Person wishes for euthanasia for another
Euthanasia of another | |||||
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case | country | location | year | summary | |
Andrew Bedner | United States | White River Junction, Vermont | 2008 | A parent is charged with critically harming his child who is on life support. If the child dies, the parent may be charged with murder. At question was whether parents should be legally allowed to make medical decisions for children they have allegedly abused. | |
Tony Bland | England | Sheffield | 1993 | Bland was the first patient in English legal history to be allowed to die by the courts through the withdrawal of life-prolonging treatment. | |
Carol Carr | United States | Georgia | 2002 | A mother euthanizes her adult sons to relieve their suffering from Huntington's disease. | |
Cruzan v. Director, Missouri Department of Health | United States | Missouri | 1990 | The parents of a woman in a persistent vegetative state request the right to remove her life support equipment. | |
Eluana Englaro | Italy | Lecco | 1992 | Parents receive permission to remove the life support from a woman in a persistent vegetative state for 17 years. | |
June Hartley | United States | California | 2009 | A sister is charged with euthanizing her brother after he has medical problems. | |
Jack Kevorkian | United States | Michigan | 1994 | A medical doctor advocates for assisted suicide and the right to die. | |
Robert Latimer | Canada | Saskatchewan | 1993 | A man euthanizes his child who has lived for years in pain. | |
Karen Ann Quinlan case
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United States | New Jersey | 1976 | A 21-year-old girl is in a persistent vegetative state. Her parents wish to remove her from artificial respiration. | |
Terri Schiavo case | United States | Florida | 2005 | A woman is in a persistent vegetative state. Her husband wishes to remove her life support. Her parents wish her to remain on life support. | |
Marlise Munoz
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United States | Texas | 2013 | A woman was declared brain-dead by her physician. Her husband and family wished to remove life support. The hospital persisted in keeping her on life support because it claims it cannot legally withdraw life support from a pregnant patient. |
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- ^ The Bulletin of the Atomic Scientists, Nov/Dec 1999, 55(6): 58–61.
- ^ "Fact Sheet on the 1946–1948 U.S. Public Health Service Sexually Transmitted Diseases (STD) Inoculation Study". United States Department of Health and Human Services. nd. Archived from the original on 2013-04-25. Retrieved 2013-04-15.
- ^ "Guatemalans 'died' in 1940s US syphilis study". BBC News. 29 August 2011. Retrieved 29 August 2011.
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- ^ The Stanford Prison Experiment – A Simulation Study of the Psychology of Imprisonment Conducted at Stanford University
- ^ "Tuskegee Study – Timeline". NCHHSTP. CDC. June 25, 2008. Retrieved December 4, 2008
- ^ "New look at antidepressant suicide risks from infamous trial", New Scientist, 16 September 2015.
- ^ a b Anne Thompson (July 9, 2001). "Paxil Maker Held Liable in Murder/Suicide". Lawyers Weekly USA.
- ^ Tobin v. SmithKline Verdict, June 6, 2001
- ^ Tobin v. SmithKline Judgment, June 6, 2001
- ^ Philip J. Hilts (June 8, 2001). "Jury Awards $6.4 Million in Killings Tied to Drug". The New York Times.
- ^ a b Draper, Robert (8 June 2003). "The Toxic Pharmacist". The New York Times Magazine. Retrieved 2 March 2021.
- ^ Barnett, Antony (4 April 2004). "UK firm tried HIV drug on orphans". The Observer. Archived from the original on 11 April 2004. Retrieved 2 March 2021.
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{{cite book}}
: CS1 maint: multiple names: authors list (link) - ^ Elliott, Carl (September–October 2010). "The deadly corruption of clinical trials. One patient's tragic, and telling, story". Mother Jones. Retrieved 4 August 2017.
- ^ "A referenced summary of the Dan Markingson case". 2012-11-23.
- ^ "Markingson letter". U of M Board of Regents. November 29, 2010. Retrieved 4 August 2017.
- ^ Hagan, Kate (14 August 2010). "Doctors tread ethical minefield, 21 years on". The Age. Retrieved 4 August 2017.