List of vaccine excipients

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This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. Vaccine ingredients and production in other nations are substantially the same. Also listed are substances used in the manufacturing process.[1]

Vaccine Excipients
Adenovirus vaccine This list refers to the type 4 and type 7 adenovirus vaccine tablets licensed in the US:
D-mannose, FD&C Yellow #6 aluminum lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin potassium, potassium phosphate, sodium bicarbonate, sucrose
BioThrax
)
vitamins
BCG (
Tice BCG
)
iron ammonium citrate, magnesium sulfate, potassium phosphate
Moderna COVID-19 Vaccine
) 		Lipids, salts, sucrose, plus in the Moderna COVID-19 Vaccine:
tromethamine, acids and acid stabilizers[2][3]
Daptacel
)
2-phenoxyethanol
Infanrix
)
bovine extract, formaldehyde, glutaraldhyde, polysorbate 80
Tripedia
)
thimerosal[4]
TriHIBit
)
thimerosal[4]
Kinrix
)
neomycin sulfate, polymyxin B, polysorbate 80
Pediarix
)
neomycin sulfate, polymyxin B, polysorbate 80
, yeast protein
Pentacel
)
2-phenoxyethanol
DT vaccine (diphtheria vaccine plus tetanus vaccine) (Sanofi
)
thimerosal
DT vaccine
(Massachusetts)
formalin
ActHIB
) 		Ammonium sulfate, formaldehyde, sucrose[5]
PedvaxHib
) 		Aluminum hydroxyphosphate sulfate[6]
Hiberix
) 		Formaldehyde, lactose[7]
Comvax
)
peptone, yeast
protein
Havrix
)
neomycin sulfate, phosphate buffers, polysorbate 20
Vaqta
) 		Amorphous aluminum hydroxyphosphate sulfate, bovine albumin or serum, formaldehyde, MRC-5 cellular protein, sodium borate
Engerix-B
)
Aluminum hydroxide, phosphate buffers, yeast
protein
Recombivax HB
) 		Amorphous aluminum hydroxyphosphate sulfate,
potassium aluminum sulfate
, soy peptone, yeast protein
Twinrix
) 		Aluminum hydroxide, aluminum phosphate, amino acids, formalin, MRC-5 cells, neomycin sulfate, phosphate buffers, polysorbate 20, yeast protein
Human papillomavirus (HPV) (Cervarix
)
vitamins
Human papillomavirus (HPV) (Gardasil
)
vitamins
, yeast protein
Afluria
)
thimerosal
(multi-dose vials only)
Agriflu
) 		Egg proteins,
kanamycin
Fluad
) 		Squalene,
kanamycin, barium, egg proteins, CTAB(cetyltrimethylammonium bromide), formaldehyde
Fluarix
)
sodium deoxycholate, sucrose, phosphate
buffer
Flublok
) 		Monobasic
salts
Flucelvax
) 		Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA,
β-propiolactone, phosphate
buffer
Flulaval
)
thimerosal, ovalbumin
Fluvirin
)
thimerosal[4]
(single-dose syringes)
Fluzone
) 		Egg protein,
thimerosal
(multi-dose containers only)
Influenza vaccine (FluMist)
porcine gelatin, monobasic potassium phosphate, monosodium glutamate, sucrose
JE-Vax
)
thimerosal
Japanese encephalitis vaccine (
Ixiaro
)
sodium metabisulphite
Menactra
) 		Formaldehyde (Each 0.5 mL dose may contain residual amounts of formaldehyde of less than 2.66 µg (0.000532%), by calculation), phosphate buffers[8]
Meningococcal vaccine (
Menomune
)
thimerosal
(multi-dose vial only)
Meningococcal vaccine (
Menveo
)
Amino acids, formaldehyde, yeast
extract
MMR-II
)
vitamins
ProQuad
) 		Bovine calf
hydrolyzed gelatin, monobasic potassium phosphate, monosodium L-glutamate, MRC-5 cellular protein, neomycin, sodium bicarbonate, sorbitol, sucrose, potassium chloride
Pneumococcal vaccine (Pneumovax) Phenol
Pneumococcal vaccine (Prevnar)
succinate buffer, yeast
Ipol
) 		Calf serum protein,
2-phenoxyethanol, polymyxin B, streptomycin
Poliovax
) 		sodium chloride
Imovax
)
neomycin sulfate, phenol
Rabies vaccine (
RabAvert
, Greedo)
potassium glutamate
RotaTeq
) 		fetal bovine serum, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, sucrose, polysorbate 80
Rotavirus vaccine (
Rotarix
)
xanthan
Td vaccine (
Decavac
)
thimerosal[4]
Td vaccine (Massachusetts)
thimerosal
(some multi-dose vials)
Tdap vaccine (Adacel)
2-phenoxyethanol
Tdap vaccine (
Boostrix
)
bovine extract, formaldehyde, glutaraldehyde, polysorbate 80
Typhim VI
)
hexadecyltrimethylammonium bromide
Typhoid vaccine (oral –
Vivotif
)
dextrose, galactose, lactose, sucrose, yeast
extract
Vaccinia (ACAM2000)
Glycerin, human serum albumin, mannitol, neomycin, phenol, polymyxin B
Varivax
)
monobasic sodium phosphate, monosodium L-glutamate, MRC-5 DNA and cellular protein, neomycin, phosphate, potassium chloride, sucrose
YF-Vax
) 		Egg protein, gelatin, sorbitol
Zoster vaccine (
Zostavax
) 		Bovine calf serum,
monobasic potassium phosphate, neomycin, potassium chloride, sucrose

See also

References

The initial list is based on information from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) and thus limited to US-approved vaccines.

  1. ^ "Vaccine Excipient & Media Summary" (PDF).
  2. ^ Juan C. Ravell (January 11, 2021). "A Simple Breakdown of the Ingredients in the COVID Vaccines". Hackensack Meridian Health. Retrieved February 3, 2021.
  3. ^ Moderna Covid-19 Vaccine Factsheet
  4. ^ a b c d Note: Thimerosal content less than 0.3 µg.
  5. ^ "ActHIB". U.S. Food and Drug Administration (FDA). 24 May 2019. Retrieved 6 May 2020.
  6. ^ "Haemophilus B Conjugate Vaccine". U.S. Food and Drug Administration (FDA). 22 July 2017. Retrieved 6 May 2020.
  7. ^ "Hiberix". U.S. Food and Drug Administration (FDA). 30 April 2018. Retrieved 6 May 2020.
  8. ^ Menactra package insert. Sanofi Pasteur. 26 August 2014 v0.12.
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