Llinás's law
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Llinás' law
)Llinás's law, or law of no interchangeability of neurons, is a statement in neuroscience made by Rodolfo Llinás in 1989, during his Luigi Galvani Award Lecture at the Fidia Research Foundation Neuroscience Award Lectures.[1]
A neuron of a given kind (e.g. a thalamic cell) cannot be functionally replaced by one of another type (e.g. an inferior ollivary cell) even if their synaptic connectivity and the type of neurotransmitter outputs are identical. (The difference is that the intrinsic electrophysiological properties of thalamic cells are extraordinarily different from those of inferior olivary neurons).[2][3]
The statement of this law is a consequence of an article written by Rodolfo Llinas himself in 1988 and published in
neurotransmitters
released by neurons was enough to determine their function. Research by Llinás and colleagues during the 80's with vertebrates revealed this previously held dogma was wrong.