Lombardo methylenation

In organic chemistry, the Lombardo methylenation is a name reaction that allows for the methylenation of carbonyl compounds with the use of Lombardo's reagent, which is a mix of zinc, dibromomethane, and titanium tetrachloride.^{[1][2][3][4][5][6][7]}

Applications

The Lombardo methylenation has been used in the total synthesis of tetrodotoxin^[8] and hirustene.^[9][10]

References

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